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| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | Density functional theory studies of pyrite FeS2 (111) and (210) surfaces显示文摘 | HUNG A MUSCAT J | 2002 | Surface Science2002，520，12： | 1 |
| 3 | Modeling the infiltration kinetics of molten aluminum into porous titanium carbide显示文摘 | Muscat D Drew R A L | 1994 | Metall Trans A1994，25，11： | 1 |
| 4 | Hyperbranched polyesteramides-- new dendritic polymers 显示文摘 | Muscat D van Benthem R A T M | 2001 | Top Curr Chem2001，212，： | 1 |
| 5 | Density-functional theory studies of pyrite FeS2 (111) and (210) surfaces 显示文摘 | HUNG A MUSCAT J YAROVSKY I RUSSO S P | 2002 | Surface Science2002，520，12： | 1 |
| 6 | Orphan nuclear receptors: therapeutic opportunities in skeletal muscle显示文摘 | SMITH A G MUSCAT G E O | 2006 | American Journal of Physiology Cell Physiology2006，291，2： | 1 |
| 7 | The ecology of Craspedacusta sowerbyi Lankester, a freshwater hydrozoan显示文摘 | Acker T S Muscat A M | 1976 | Am Midl Nat1976，95，： | 1 |
| 8 | Molding the infiltration kinetics of molten aluminum into porous titanium carbide 显示文摘 | MUSCAT D DREW R A L | 1994 | Metall Trans1994，25，： | 1 |
| 9 | The ecology of Craspedacusta sowerbii lankester, a freshwater hydrozoan显示文摘 | Acker T S Muscat A M | 1976 | The American Midian Naturalist1976，95，： | 1 |
| 10 | Density-functional theory studies of pyrite FeS2 (100) and (110) surfaces显示文摘 | HUNG A MUSCAT J YAROVSDY I RUSSO S P | 2002 | Surface Science2002，513，3： | 1 |
| 11 | Effects of pimozide on sucrose consumption and preference 显示文摘 | Towell A Muscat R Willner P | 1987 | Psychopharmacology ( Berl )1987，92，2： | 1 |
| 12 | The UDP-glucuronosyltransferase 2B17 gene deletion polymorphism:sex-specific association with urinary 44( methylnitrosamino ) -1 -( 3-pyridyl ) -1 -butanol glucuronidation phenotype and risk for lung cancer显示文摘 | Gallagher C J Muscat J E Hicks A N | 2007 | Cancer Epidemiol Biomarkers Prey2007，16，4： | 1 |
| 13 | Density-functional theory studies of pyrite FeS2 (111) and (210) surfaces显示文摘 | HUNG A MUSCAT J YAROVSKY I RUSSO S P | 2002 | Surface Science2002，520，1： | 1 |
| 14 | The chicken ovalbumin up-stream promoter - transcription factors modulate genes and path- ways involved in skeletal muscle cell metabolism 显示文摘 | MYERS S A WANG S C MUSCAT G E | 2006 | J Biol Chem2006，281，24： | 1 |
| 15 | Expression vectors encoding human growth hormone(hGH) controlled by human musclespecific promoters:prospects for regulated production of hGH delivered by myoblast transfer or intravenous injection显示文摘 | Dahler A Wade R P Muscat G E | 1994 | Gene1994，145，2： | 1 |
| 16 | On the predietion of band gaps from hybrid functional theory显示文摘 | Warder A Harrison N M | 2001 | Chemical Physics Letters2001，13，： | 1 |
| 17 | A New Route to Self-Assembled Tin Dioxide Nanospheres: Fabrication and Chacterization显示文摘 | Deng Z T Peng B Chen D Tang F Q Muscat A J | 2008 | Langmuir2008，24，11： | 1 |
| 18 | Nd3+ doped optical fiber temperature sensor using the fluorescence intensity ratio technique显示文摘 | Wade S A Muscat J C Collins S F | 1999 | Review of Scientific Instruments1999，70，11： | 1 |
| 19 | A noval procedure for dissociating the anatomical bases of the behavioral effects of amphetamine显示文摘 | TOWELL A WILLNER P MUSCAT R | 1987 | Pharmacol Biochem Behav1987，28，： | 1 |
| 20 | On the prediction of band gaps from hybrid functional theory显示文摘 | Muscat J Wander A Harrison N M | 2001 | Chemical Physics Letters2001，，： | 1 |
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