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| 1 | Utility of flexible fiberoptic bronchoscopy for critically ill pediatric patients:A systematic review显示文摘AIM: To investigate the diagnostic yield, therapeutic efficacy, and rate of adverse events related to flexible fiberoptic bronchoscopy(FFB) in critically ill children. METHODS: We searched Pub Med, SCOPUS, OVID, and EMBASE databases through July 2014 for English language publications studying FFB performed in the intensive care unit in children < 18 years old. We identified 666 studies, of which 89 full-text studies were screened for further review. Two reviewers independently determined that 27 of these studies met inclusion criteria and extracted data. We examined the diagnostic yield of FFB among upper and lower airway evaluations, as well as the utility of bronchoalveolar lavage(BAL). RESULTS: We found that FFB led to a change in medical management in 28.9%(range 21.9%-69.2%) of critically ill children. The diagnostic yield of FFB was 82%(range 45.2%-100%). Infectious organisms were identified in 25.7%(17.6%-75%) of BALs performed, resulting in a change of antimicrobial management in 19.1%(range: 12.2%-75%). FFB successfully reexpanded atelectasis or removed mucus plugs in 60.3%(range: 23.8%-100%) of patients with atelectasis. Adverse events were reported in 12.9%(range: 0.5%-71.4%) of patients. The most common adverse effects of FFB were transient hypotension, hypoxia and/or bradycardia that resolved with minimal intervention, such as oxygen supplementation or removal of the bronchoscope. Serious adverse events were uncommon; 2.1% of adverse events required intervention such as bag-mask ventilation or intubation and atropine for hypoxia and bradycardia, normal saline boluses for hypotension, or lavage and suctioning for hemorrhage. CONCLUSION: FFB is safe and effective for diagnostic and therapeutic use in critically ill pediatric patients. | Aida Field-Ridley Viyeka Sethi Shweta Murthi Kiran Nandalike Su-Ting T Li | 2015 | World Journal of Critical Care Medicine2015，4，1： | 12 |
| 2 | A case study of geotextile-reinforced embankment on soft ground显示文摘 | Dennes T Bergado Pham V Long B.R Srinivasa Murthy | 2002 | Geotextiles and Geomembranes2002，，6： | 2 |
| 3 | Automatic extraction of tank outlets in a sub-watershed using digital elevation models显示文摘 | Nisar A hamed T R Gopal Rao K Murthy J S R | 2002 | Agricultural Water Management2002，57，3： | 1 |
| 4 | T2NOM0 esophageal cancer 显示文摘 | Rice T W Mason D P Murthy S C | 2007 | J Thorac Cardiovasc Surg2007，133，： | 1 |
| 5 | Spectrophotometric Determination of Flutamide, Nimesulide and Meloxicam显示文摘 | Murthy T K Reddy M N Reddy M D | 2001 | Asian J Chem2001，13，3： | 1 |
| 6 | Prediction of compressibility of overconsolidated uncemented soils显示文摘 | NAGARAJ T S SRINIVASA MURTHY B R | 1986 | Journal of Geoteehnieal Engineering1986，112，： | 1 |
| 7 | pH-sensitive polymers that enhance intracellular drug delivery in vivo显示文摘 | Kyriakides T R Cheung C Y Murthy N | 2002 | J Control Release2002，78，13： | 1 |
| 8 | Total sulphur amino acid requirement of the Indian major carp, Labeo rohita (Hamilton)显示文摘 | Murthy R K Varghese T J | 1998 | Aquaculture Nutrition1998，4，1： | 1 |
| 9 | Analysis of compressibility of sensitive soils显示文摘 | NAGARAJ T S SRINIVASA MURTHY B R VATSALA A | 1990 | Journal of Geoteehnieal Engineering1990，116，： | 1 |
| 10 | A comparison of different algorithms for cylindricity evaluation 显示文摘 | Murthy T S R | 1982 | Int J Mach Tools & Manufact1982，22，2： | 1 |
| 11 | Analytical properties of 2-hydroxy-1-acetonaphthone thiosemicarbazone:spectrophotometric determination of platinum显示文摘 | MURTHY G V R REDDY T S | 1993 | Asian Journal of Chemistry1993，5，4： | 1 |
| 12 | Analysis of compressibility of sensitive soils显示文摘 | Nagaraj T S Murthy B R S | 1990 | Journal of Geotechnical Engineer- ing ASCE1990，116，1： | 1 |
| 13 | Product warranty logistics:issues and challenges显示文摘 | D N P MURTHY O SOLEM T ROREN | 2004 | European Journal of Operational Research2004，，156： | 1 |
| 14 | GIS-basedfuzzy membership model for crop -land suitability analysis 显示文摘 | NISAR A T R GOPAL R K MURTHY J S R | 2000 | Agricultural Systems2000，63，2： | 1 |
| 15 | Experimental studies o,1 the influence of intermediate principal stress and inclination onI the mechanical behaviour of angular sands显示文摘 | KANDASAMI R K MURTHY T G | 2015 | Granula1 Matter2015，17，2： | 1 |
| 16 | A simpleapproach for evaluation of cylindrical surfaces显示文摘 | MURTHY T S R RAO S Y PETERS J | 1981 | CIRPAnnals-Manufacturing Technology1981，30，1： | 1 |
| 17 | Product Warranty Logistics: Lssues and Challenges显示文摘 | Murthy D Solem O Roren T | 2004 | European Journal of Operational Research2004，156，1： | 1 |
| 18 | Synthesis and Consolidation of Titanium Diboride 显示文摘 | Subramanian C Ch T S R Murthy Suri A K | 2007 | International Jonrnal of Refractory Metals & Hard Materials2007，，25： | 1 |
| 19 | Effect of age on the enzymes of tricarboxylic acid and related cycles in Mycobacterium tuberculosis H37Rv显示文摘 | Murthy P S Sirsi M Ramakrishnan T | 1973 | Am Rev Respir Dis1973，108，3： | 1 |
| 20 | Factors affecting floe properties duringaerobic digestion: implications for dewatering显示文摘 | Murthy S N Novak J T | 1999 | Water Envi-ronment Research1999，71，2： | 1 |
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