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| 1 | Efficacy of peroral endoscopic myotomy vs other achalasia treatments in improving esophageal function显示文摘AIM: To assess and compare the esophageal function after peroral endoscopic myotomy(POEM) vs other conventional treatments in achalasia.METHODS: Chart review of all achalasia patients who underwent POEM, laparoscopic Heller myotomy(LHM) or pneumatic dilation(PD) at our institution between January 2012 and March 2015 was performed. Patient demographics, type of achalasia, prior treatments, pre- and post-treatment timed barium swallow(TBE) and high-resolution esophageal manometry(HREM) findings were compared between the three treatment groups. Patients who had both pre- and 2 mo posttreatment TBE or HREM were included in the final analysis. TBE parameters compared were barium column height, width and volume of barium remaining at 1 and 5 min. HREM parameters compared were basal lower esophageal sphincter(LES) pressures and LES-integrated relaxation pressures(IRP). Data are presented as mean ± SD, median [25th, 75 th percentiles] or frequency(percent). Analysis of variance, KruskalWallis test, Pearsons χ~2 test and Fishers Exact tests were used for analysis.RESULTS: A total of 200 achalasia patients were included of which 36 underwent POEM, 22 underwent PD and 142 underwent LHM. POEM patients were older(55.4 ± 16.8 years vs 46.5 ± 15.7 years, P = 0.013) and had higher BMI than LHM(29.1 ± 5.9 kg/m^2 vs 26 ± 5.1 kg/m^2, P = 0.012). More number of patients in POEM and PD groups had undergone prior treatments compared to LHM group(72.2% vs 68.2% vs 44.3% respectively, P = 0.003). At 2 mo post-treatment, all TBE parameters including barium column height, width and volume remaining at 1 and 5 min improved significantly in all three treatment groups(P = 0.01 to P < 0.001) except the column height at 1 min in PD group(P = 0.11). At 2 mo post-treatment, there was significant improvement in basal LES pressure and LES-IRP in both LHM(40.5 mm Hg vs 14.5 mm Hg and 24 mm Hg vs 7.1 mm Hg respectively, P < 0.001) and POEM groups(38.7 mm Hg vs 11.4 mm Hg and 23.6 mm Hg vs 6.6 mm Hg respectively, P < 0.001). However, when the efficacy of three treatments were compared to each other in terms of improvement in TBE or HREM parameters at 2 mo, there was no significant difference(P > 0.05).CONCLUSION: POEM, PD and LHM were all effective in improving esophageal function in achalasia at shortterm. There was no difference in efficacy between the three treatments. | Madhusudhan R Sanaka Umar Hayat Prashanthi N Thota Ramprasad Jegadeesan Monica Ray Scott L Gabbard Neha Wadhwa Rocio Lopez Mark E Baker Sudish Murthy Siva Raja | 2016 | World Journal of Gastroenterology2016，22，20： | 7 |
| 2 | 相对于男性,女性进行冠状动脉造影产生的额外的心血管病风险与严重受损的冠状动脉血流储备,而非阻塞性疾病相关显示文摘与男性相比,女性的心血管病死亡率更高,但是阻塞性冠状动脉疾病(coronary artery disease,CAD)在女性中不太普遍。冠状动脉血流储备(coronary flow reserve,CFR)是大、小血管CAD和心肌缺血的综合测量指标,可识别出具有心血管病死亡风险的患者,但其在临床实践中不是常规测量的指标。该研究试图调查性别、CFR和血管造影CAD严重程度对不良心血管事件的影响。 | 刘莉 叶鹏 Taqueti VR Shaw LJ Cook NR Murthy VL Shah NR Foster CR Hainer J Blankstein R Dorbala S Di Carli MF | 2016 | 中华高血压杂志2016，24，11： | 2 |
| 3 | Automatic extraction of tank outlets in a sub-watershed using digital elevation models显示文摘 | Nisar A hamed T R Gopal Rao K Murthy J S R | 2002 | Agricultural Water Management2002，57，3： | 1 |
| 4 | A New Approach for Scheduling of Parallelizable Tasks in Real-Time Multiprocessor Systems显示文摘 | Manimaran G Murthy C S R Ramamritham K | 1998 | Real-Time Systems1998，15，1： | 1 |
| 5 | The six minute walk test accurately estimates mean peak oxy- gen uptake显示文摘 | ROSS R M MURTHY J N WOLLAK I D | 2010 | BMC Pulm Med2010，10，31： | 1 |
| 6 | Clinico- pathologic study of dextran sulfate sodium experimental mu- rine colitis显示文摘 | COPPER H S MURTHY S N SHAH R S | 1993 | Lab Invest1993，69，： | 1 |
| 7 | Solar-assisted vapor compression/absorption cascaded air-conditioning systems 显示文摘 | Chinnappa J C Crees M R Murthy S S | 1993 | Solar Energy1993，50，5： | 1 |
| 8 | Modulo con- version method for estimating the direction of arrival 显示文摘 | Sundaram K R Mallik R K Murthy U M S | 2000 | IEEE Transactions on Aerospace and Electronic Systems2000，36，4： | 1 |
| 9 | Arterial switch operation with in situ coronary realtocation for transposition of great arteries with single coronary artery 显示文摘 | Murthy KS Coelho R Kulkarni S | 2004 | Eur J Cardiothorac Surg2004，25，： | 1 |
| 10 | Prediction of compressibility of overconsolidated uncemented soils显示文摘 | NAGARAJ T S SRINIVASA MURTHY B R | 1986 | Journal of Geoteehnieal Engineering1986，112，： | 1 |
| 11 | Thermochemotherapy in hereditary retinoblatoma 显示文摘 | Murthy R Honayar SG Naik M | 2003 | Br J Ophthalmol2003，87，10： | 1 |
| 12 | On using peak amplitude and rise time for AE source显示文摘 | Majeed M A Murthy C R L | 2002 | Sadhana2002，27，3： | 1 |
| 13 | Catalytic Vapor Phase Reduction of Nitrobenzene to Aniline in Fluidized Beds显示文摘 | Deshpande P K Kuloor N R | 1963 | Chemical Age of India1963，14，： | 1 |
| 14 | CFD simulation and experimental validation studies on hydrocyclone 显示文摘 | BHASKAR K U MURTHY Y R RAJU M R | 2007 | Minerals Engineering2007，20，1： | 1 |
| 15 | An efficient dynamic scheduling algorithm for multiprocessor real-time systems 显示文摘 | Manimaran G Murthy C S R | 1998 | IEEE Transactions on Parallel and Distributed Systems1998，9，3： | 1 |
| 16 | Analysis of a non-linear frequency diverse clutter suppression algorithm显示文摘 | Bilgutay NM Bencharit U Murthy R | 1990 | Ultrasonics1990，28，3： | 1 |
| 17 | pH-sensitive polymers that enhance intracellular drug delivery in vivo显示文摘 | Kyriakides T R Cheung C Y Murthy N | 2002 | J Control Release2002，78，13： | 1 |
| 18 | Median stemotomy single stage complete unifocalization for pulmonary atresia,major aorto-pulmonary collateral arteries and VSD-early experience显示文摘 | Murthy KS Krishnanaik S Coelho R | 1999 | Eur J Cardiothorac Surg1999，16，1： | 1 |
| 19 | Total sulphur amino acid requirement of the Indian major carp, Labeo rohita (Hamilton)显示文摘 | Murthy R K Varghese T J | 1998 | Aquaculture Nutrition1998，4，1： | 1 |
| 20 | Analysis of compressibility of sensitive soils显示文摘 | NAGARAJ T S SRINIVASA MURTHY B R VATSALA A | 1990 | Journal of Geoteehnieal Engineering1990，116，： | 1 |
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