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| 1 | FGF21 treatment ameliorates alcoholic fatty liver through activation of AMPK-SIRT1 pathway显示文摘成纤维细胞生长因素 21 (FGF21 ) , FGF 总科的一个最近识别的成员,主要从肝和脂肪质的纸巾被分泌并且在改进新陈代谢的症候群和动态平衡起一个重要作用。这研究的目的是在含酒精的脂肪肝疾病(AFLD ) 评估 FGF21 的角色并且决定它是否在 AFLD 上有治疗学的效果。在这份报纸,我们在长期的乙醇 gavage 和对待白酒的 HepG2 房间的一个鼠科的模型在导致白酒的肝损害上测试了 FGF21 的效果。男千米;公里老鼠每天收到了 5 g/kg 乙醇 gavage 的单个剂量 6 个星期,它导致了重要脂肪肝和肝损害。导致白酒的脂肪肝房间模型被在 75 公里的最后的集中增加乙醇进 HepG2 房间文化的媒介 9 天完成。结果与 recombinant FGF21 显示出那个处理在长期的乙醇 gavage 和对待白酒的 HepG2 房间的一个鼠科的模型的改善含酒精的脂肪肝和肝损害。另外, FGF21 处理下面调整丰满的酸的肝的表示合成的关键酶,激活的肝的 AMPK-SIRT1 小径和显著地下面调整的肝的氧化压力蛋白质。一起拿, FGF21 由 AMPK-SIRT1 小径的激活在 vitro 并且在 vivo 改正 AFLD 的多重新陈代谢的参数。 | Shenglong Zhu Lei Ma Yunzhou Wu Xianlong Ye Tianyuan Zhang Qingyang Zhang Lubna Muhi Rasoul Yunye Liu MO Guo Bing Zhou Guiping Ren Deshan Li | 2014 | Acta Biochimica et Biophysica Sinica2014，46，12： | 11 |
| 2 | Mass forming autoim mune pancreatitis and pancreatic carcinoma: differential diagnosis on the basis of computed tomography and magnetic resonance cholangiopancreatography, and diffusion weighted imaging findings显示文摘 | Muhi A Ichikawa T Motosugi U | 2012 | J Magn Reson Imaging2012，35，4： | 1 |
| 3 | Brain transcriptome profiles in mouse model simulating features of post-traumatic stress disorder显示文摘 | Muhie S Gautam A Meyerhoff J | 2015 | Mol Brain2015，8，： | 1 |
| 4 | Importation and co-circulation of multiple serotypes of dengue virus in Sarawak, Malaysia显示文摘 | Edward C. Holmes Phaik-Hooi Tio David Perera Jamail Muhi Jane Cardosa | 2009 | Virus Research2009，，： | 1 |
| 5 | Sepsis and multiple organ failure-update of current therapeutic concepts显示文摘 | Sablotzki A Muhiing J Czeslick E | 2005 | Anasthesiol Intensivrned Notfallmed Schmerzther2005，40，9： | 1 |
| 6 | Thermal fatigue cracking of die-casting dies显示文摘 | MUHI M TUSEK J KOSEL F | 2005 | Original Scientific Paper2005，，9： | 1 |
| 7 | Diagnosis of colorectal hepatic metastases: comparison of contrast-enhanced CT, contrast-enhanced US, superparamagnetic iron oxide-enhanced MRI, and gadoxetic acid-enhanced MRI显示文摘 | Muhi A Ichikawa Tv Motosugi Uv | 2011 | J Magri Reson Imaging2011，34，2： | 1 |
| 8 | Diagnosis of colorectal hepatic metastases: comparison of contrastenhanced CT, con- trast-enhanced US, superparamagnetic iron oxideenhanced M RI, and gadoxetic acid-enhanced MRI 显示文摘 | Muhi A Ichikawa T Motosugi U | 2011 | J Magn Reson Im- aging2011，34，2： | 1 |
| 9 | Numerical optimisation and experimental validation of divided rail freight brake disc crown显示文摘In this study, numerical optimisation and experimental validation of a divided rail freight brake disc crown made of grey cast iron EN-GJL-250 is presented.The analysed brake disc is used in rail freight wagons and possesses a load capacity of 22.5 tons per axle. Two of the divided rail freight brake discs are mounted on each axle.With the aid of numerical analysis, the thermal dissipation properties of the brake disc were optimised and ventilation losses were reduced, and the numerical results were compared with experimental results. A one-way fluid–structure interaction analysis was performed. A computational fluid dynamic model of a divided rail freight brake disc, used to predict air flow properties and heat convection, was incorporated into a finite element model of the disc and used to evaluate the temperature of the disc. A numerical parametrical optimisation of cooling ribs of the brake disc was also performed, and novel optimised cooling ribs were developed. A transient thermal numerical analysis of the brake disc was validated using temperature measurements obtained during a braking test on a test bench. The ventilation losses of the brake disc were measured on a test bench specifically designed for the task, and the losses were compared to the simulation results. The experimentally obtained ventilation losses and temperature measurements compared favourably with the simulation results, confirming that this type of simulation process may be confidently applied in the future. Through systematic optimisation of the divided rail freight brake disc, ventilation losses were reduced by 37% and the mass was reduced by 21%, resulting in better thermal performance that will bring with it substantial energy savings. | Uro? Grivc David Derzi? Simon Muhi? | 2019 | Journal of Modern Transportation2019，27，1： | 1 |
| 10 | Mass-forming autoimmune pancreatitis and pancreatic carcinoma: differ- ential diagnosis on the basis of computed tomography and magnetic resonance cholangiopancreatography, and diffu- sion-weighted imaging findings 显示文摘 | Muhi A Ichikawa T Motosugi U | 2012 | J Magn Reson Ima- ging2012，35，4： | 1 |
| 11 | High-b-value diffusion-weighted MR imaging of hepatocellular lesions:estimation of grade of malignancy of hepatocellular carcinoma显示文摘 | Muhi A Ichikawa T Motosugi U | | 0，，5： | 1 |
| 12 | Changes concurrent with orthodontic treatment when maxillary expansion is a primary goal显示文摘 | Ladner PT Muhi ZF | 1995 | Am J Orthod Dentofac Orthop1995，108，： | 1 |
| 13 | Magnetic resonance diffusion-weighted imaging in the characterization of pancreatic mucinous cystic lesions显示文摘 | Z. Fatima T. Ichikawa U. Motosugi A. Muhi K. Sano H. Sou H. Haradome S. Kiryu T. Araki | 2010 | Clinical Radiology2010，，： | 1 |
| 14 | Staging liver fibrosis by using liver-enhancement ratio of gadoxetic acid-enhanced MR imaging: comparison with aspartate aminotransferase-to-platelet ratio index显示文摘 | Utaroh Motosugi Tomoaki Ichikawa Mitsuhiko Oguri Katsuhiro Sano Hironobu Sou Ali Muhi Masanori Matsuda Hideki Fujii Nobuyuki Enomoto Tsutomu Araki | 2011 | Magnetic Resonance Imaging2011，，8： | 1 |
| 15 | Magnetic Resonance elastography as a predictor of insufficient liver enhancement on gadoxetic acid-enhanced hepatocyte-phase magnetic resonance imaging in patients with type C hepatitis and child-pugh class A disease显示文摘 | Motosugi U Ichikawa T Muhi A | 2012 | Invest Radiol2012，47，： | 1 |
| 16 | Medical aspects of the persistent vegetative state 显示文摘 | The Muhi - Society Task Force on PVS | 1994 | N Engl J Med1994，330，21： | 1 |
| 17 | Mass-forming autoimmune pancreatitis and pancreatic carcinoma: differential diagnosis on the basis of computed tomography and magnetic res- onance cholangiopancreatography,and diffusion-weighted imag- ing findings 显示文摘 | MUHI A ICHIKAWA T MOTOSUGI U | 2012 | J Magn Reson Imaging2012，35，4： | 1 |
| 18 | Changes concurrent with orthodontic treatment when maxillary expasion is a primary goal 显示文摘 | Ladner PT Muhi ZF | 1995 | Am J Orthod Dentofac Orthop1995，108，： | 1 |
| 19 | High-b-value diffusion-weighted MR imaging of hepatocellular le- sions: estimation of grade of malig-nancy of he- patocellular carcinoma 显示文摘 | Muhi A Ichikawa T Motosugi U | 2009 | J Magn Reson Imaging2009，30，5： | 1 |
| 20 | Highb-value diffusion-weigh- ted MR imaging of hepatooellular lesions : estimation of grade of ma- lignancy of hepatocei|ular carcinoma 显示文摘 | Muhi A Ichikawa T Motosugi U | 2009 | ] Magn Reson Imaging2009，30，： | 1 |
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