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| 1 | Coeliac disease in Dutch patients with Hashimoto’s thyroiditis and vice versa显示文摘AIM: To define the association between Hashimoto’s thyroiditis and coeliac disease in Dutch patients. METHODS: A total of 104 consecutive patients with Hashimoto’s thyroiditis underwent coeliac serological tests (antigliadins, transglutaminase and endomysium antibodies) and HLA-DQ typing. Small intestinal biopsy was performed when any of coeliac serological tests was positive. On the other hand, 184 patients with coeliac disease were subjected to thyroid biochemical (thyroid stimulating hormone and free thyroxine) and thyroid serological tests (thyroglobulin and thyroid peroxidase antibodies). RESULTS: Of 104 patients with Hashimoto’s thyroiditis, sixteen (15%) were positive for coeliac serology and five patients with documented villous atrophy were diagnosed with coeliac disease (4.8%; 95% CI 0.7-8.9). HLA-DQ2 (and/or -DQ8) was present in all the five and 53 patients with Hashimoto’s thyroiditis (50%; 95% CI 43-62). Of 184 patients with coeliac disease, 39 (21%) were positive for thyroid serology. Based on thyroid biochemistry, the 39 patients were subclassified into euthyroidism in ten (5%; 95% CI 2-9), subclinicalhypothyroidism in seven (3.8%; 95% CI 1.8-7.6), and overt hypothyroidism (Hashimoto’s thyroiditis) in 22 (12%; 95% CI 8-16). Moreover, four patients with coeliac disease had Graves’ disease (2%; 95% CI 0.8-5) and one patient had post-partum thyroiditis. CONCLUSION: The data from a Dutch population confirm the association between Hashimoto’s thyroiditis and coeliac disease. Screening patients with Hashimoto’s thyroiditis for coeliac disease and vice versa is recom- mended. | Muhammed Hadithi Hans de Boer Jos WR Meijer Frans Willekens Jo A Kerckhaert Roel Heijmans Amado Salvador Pea Coen DA Stehouwer Chris JJ Mulder | 2007 | World Journal of Gastroenterology2007，13，11： | 4 |
| 2 | Retrospective analysis of old-age colitis in the Dutch inflammatory bowel disease population显示文摘AIM: To describe the characteristics of Dutch patients with chronic inflammatory bowel disease (IBD) first diagnosed above 60 years of age-a disease also known as old-age colitis (OAC) and to highlight a condition that has a similar appearance to IBD, namely segmen- tal colitis associated with diverticular disease (SCAD). METHODS: A retrospective longitudinal survey of patient demographic and clinical characteristics, disease characteristics, diagnostic methods, management and course of disease was performed. The median follow-up period was 10 years. RESULTS: Of a total of 1100 IBD patients attending the Department of Gastroenterology, 59 (5%) [median age 82 years (range 64-101); 25 male (42%)] were identified. These patients were diagnosed with ulcerative colitis (n = 37, 61%), Crohn’s disease (n = 14, 24%), and indeterminate colitis (n = 8, 15%). Remission was induced in 40 (68%) patients within a median interval of 6 mo (range 1-21) and immunosuppressive therapy was well tolerated. Histological evaluation based on many biopsy samples and the course of the disease led to other diagnosis, namely SCAD instead of IBD in five (8%) patients. CONCLUSION: OAC is not an infrequent problem for the gastroenterologist, and should be considered in the evaluation of older patients with clinical featuressuggestive of IBD. Extra awareness and extensive biopsy sampling are required in order to avoid an erroneous diagnosis purely based on histological mimicry of changes seen in SCAD, when diagnosing IBD in the presence of diverticulosis coli. | Muhammed Hadithi Marcel Cazemier Gerrit A Meijer Elisabeth Bloemena Richel J Felt-Bersma Chris J Mulder Stephan GM Meuwissen Amado Salvador Pea Adriaan A van Bodegraven | 2008 | World Journal of Gastroenterology2008，14，20： | 3 |
| 3 | Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease显示文摘AIM: To investigate the effect of vitamin supplements on homocysteine levels in patients with celiac disease. METHODS: Vitamin B6, folate, vitamin B12, and fasting plasma homocysteine levels were measured in 51 consecutive adults with celiac disease [median (range) age 56 (18-63) years; 40% men, 26 (51%) had villous atrophy, and 25 (49%) used B-vitamin supplements] and 50 healthy control individuals matched for age and sex. Finally, the C677T polymorphism of 5,10-methylene tetrahydrofolate reductase (MTHFR) was evaluated in 46 patients with celiac disease and all control individuals. RESULTS: Patients with celiac disease and using vitamin supplements had higher serum vitamin B6 (P = 0.003),folate (P < 0.001), and vitamin B12 (P = 0.012) levels than patients who did not or healthy controls (P = 0.035, P < 0.001, P = 0.007, for vitamin B6, folate, and vitamin B12, respectively). Lower plasma homocysteine levels were found in patients using vitamin supplements than in patients who did not (P = 0.001) or healthy controls (P = 0.003). However, vitamin B6 and folate, not vitamin B12, were significantly and independently associated with homocysteine levels. Twenty-four (48%) of 50 controls and 23 (50%) of 46 patients with celiac disease carried the MTHFR thermolabile variant T-allele (P = 0.89). CONCLUSION: Homocysteine levels are dependent on Marsh classification and the regular use of B-vitamin supplements is effective in reduction of homocysteine levels in patients with celiac disease and should be considered in disease management. | Muhammed Hadithi Chris JJ Mulder Frank Stam Joshan Azizi J Bart A Crusius Amado Salvador Pea Coen DA Stehouwer Yvo M Smulders | 2009 | World Journal of Gastroenterology2009，15，8： | 3 |
| 4 | Influence of peptides,amino acids and urea on microbial activity in the rumen of sheep recei ving grass bay on the growth of rumen bacteria in vitro显示文摘 | CRUZSOTO R MUHAMMED S A NEWBOLD C J | 1994 | Anim Feed Sci Technol1994，49，： | 1 |
| 5 | The effects of cypennethrin(asynthetic pyrethroid)on some biochemical parameters (Ca, P ,Na and TP) of rainbow trout ( Oncorhynchus mykiss ) 显示文摘 | MUHAMMED A SAlT K M HALILOULU U H | 2002 | Turk J Vet Anita Sci2002，26，： | 1 |
| 6 | Utility of DNA methylation markers for diagnosing cancer 显示文摘 | QURESHI SOHAIL A MUHAMMED U B | 2010 | International Journal of Surgery2010，8，3： | 1 |
| 7 | Influence of peptides,amino acids and vrea on microbial activity in the rumen of sheep receiving grass hay and on the growth of rumen bacteria in vitro显示文摘 | CRUE S MUHAMMED R NEWBOLD S A C J | 1994 | Animal Feed Science and Technology1994，49，： | 1 |
| 8 | Novel flow injection synthesis of iron oxide nanuparticles with narrow size distribution显示文摘 | Salazar Alvarez G Muhammed M Zagorodni Andrei A | 2006 | Chem Fag Sci2006，61，14： | 1 |
| 9 | Development of nanocerium oxide incorporated aluminium alloy sacrificial anode for marine applications 显示文摘 | Shibli S M A Archana S R Muhamed A P | 2008 | Corros Sci2008，50，8： | 1 |
| 10 | Effect ofdust accumulalion on the power outputs of solar photovol-taic modules显示文摘 | MUHAMMED J ADINOYI SYED A | 2013 | Renewable Knergy2013，60，： | 1 |
| 11 | Magnesium sulphate therapy in eclampsia:the Sokoto(ultra short)regimen显示文摘 | Bissallah A Ekele Danjuma Muhammed Lawal N BeUo | 2009 | BMC Res Notes2009，19，2： | 1 |
| 12 | The influence of arbuscular mycorrhizal colonization on key growth parameters and fruityield of peper pants grown at high salinity显示文摘 | CENGIZ K MUHAMMED A OSMAN S | 2009 | Scientia Horticulturae2009，121，： | 1 |
| 13 | Synthesis of Nick el-rubb er Nan composites and Evaluation of Their Dielectric Properties显示文摘 | Muham mad Abdul Jam ala E Joy P A Kuri an P | 2009 | Materials Science an d Engi- neering: B2009，156，123： | 1 |
| 14 | Chlorella Sorokini- ana Immobilized on the Biomatrix of Vegetable Sponge of Luf- fa Cylindrical: A New Systerm to Remove Cadmium Ftom Contaminated Aqueous Medium显示文摘 | NASREEN A ASMA S MUHAMMED II | 2003 | Bioresource Technology2003，88，2： | 1 |
| 15 | Kinetics and optimization of photolytic decoloration of carmine by UV/H2O2显示文摘 | Fatima H A Muhammed A R Salman A | 2007 | Dyes and Pigments2007，75，1： | 1 |
| 16 | Feature vector based analysis of hyperspectral crop reflectance data for discrimination and quan- tification of fungal disease severity in wheat 显示文摘 | Muhammed H H Larsolle A | 2003 | Biosystems Engineering2003，86，2： | 1 |
| 17 | Antiglycation properties of aged garlic extract:Role in prevention of diabetic complications显示文摘 | Muhammed SA Nessar A | | 0，，03： | 1 |
| 18 | 查看详情显示文摘 | Li S Qin J Fornara A Toprak M Muhammed M Kim D K | | 0，，： | 1 |
| 19 | Drug-target network显示文摘 | Muhammed A Yildirm Kwang-II Gob Michael E Cusick | 2007 | Nature Biotechnology2007，25，10： | 1 |
| 20 | Selective extraction of palladium(Ⅱ) from chloride solutions with nonylthiourea dissolved in chloroform显示文摘 | Uheida A Zhang Y Muhammed M | 2002 | Solv Extr Ion Exch2002，20，6： | 1 |
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