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| 1 | Intensivist-based deep sedation using propofol for pediatric outpatient flexible bronchoscopy显示文摘AIM To evaluate the safety and efficacy of sedating pediatric patients for outpatient flexible bronchoscopy.METHODS A retrospective chart review was conducted for all children, age 17 years or under who underwent flexible bronchoscopy under deep sedation in an outpatient hospital-based setting. Two sedation regimens were used; propofol only or ketamine prior to propofol. Patients were divided into three age groups; infants(less than 12 mo), toddlers(1-3 years) and children(4-17 years). Demographics, indication for bronchoscopy, sedative dosing, sedation and recovery time and adverse events were reviewed.RESULTS Of the total 458 bronchoscopies performed, propofol only regimen was used in 337(74%) while propofol and ketamine was used in 121(26%). About 99% of the procedures were successfully completed. Children in the propofol + ketamine group tend to be youngerand have lower weight compared to the propofol only group. Adverse events including transient hypoxemia and hypotension occurred in 8% and 24% respectively. Median procedure time was 10 min while the median discharge time was 35 min. There were no differences in the indication of the procedure, propofol dose, procedure or recovery time in either sedative regimen. When compared to other age groups, infants had a higher incidence of hypoxemia.CONCLUSION Children can be effectively sedated for outpatient flexible bronchoscopy with high rate of success. This procedure should be performed under vigilance of highly trained providers. | Kamal Abulebda Samer Abu-Sultaneh Sheikh Sohail Ahmed Elizabeth A S Moser Renee C McKinney Riad Lutfi | 2017 | World Journal of Critical Care Medicine2017，6，4： | 8 |
| 2 | Percutaneous aspiration and drainage with adjuvant medical therapy for treatment of hepatic hydatid cysts显示文摘AIM:To determine the efficacy and success of percutaneous aspiration irrigation and reaspiration(PAIR) in the management of hepatic hydatidosis.METHODS:Twenty-six patients with 32 hepatic hydatid cysts had PAIR.Twenty-two patients received at least 2 wk of drug therapy before the procedure was carried out to reduce the risk of recurrence from spillage during the procedure.The procedure was performed under local anesthesia with a 19-gauge 20 cm long needle,the cyst was punctured,cystic content(approximately 30 mL) was aspirated by a 12-14 F pigtail catheter and aspirated fluids were sent for analysis.Once the cyst was almost empty,two-thirds of the net amount of material aspirated was replaced by hypertonic saline and left in the cavity for about 30 min,with the catheter left in place for reaspiration of most of the fluid.When the amount of fluid drained was less than 10 mL per 24 h,the drainage catheter was removed.RESULTS:All 32 cysts showed evidence of immediate collapse after completion of the procedure,and before discharge from hospital,ultrasound examination showed fluid reaccumulation in all cysts.Serial follow-up showed a progressive decrease in the size and change in the appearance of cysts.To confirm the sterility of these cystic cavities,seven cysts were reaspirated on average 3 mo after the procedure.Investigations revealed no viable scolices.CONCLUSION:PAIR using hypertonic saline is very effective and safe with proper precautions. | Mohammed I Yasawy Abdelrahman E Mohammed Sammak Bassam Mohammed A Karawi Sohail Shariq | 2011 | World Journal of Gastroenterology2011，17，5： | 3 |
| 3 | Probiotic Medilac-S^(█) for the induction of clinical remission in a Chinese population with ulcerative colitis: A systematic review and meta-analysis显示文摘AIM To assess the effects of probiotic Medilac-S~ as adjunctive therapy for the induction of remission of ulcerative colitis(UC) in a Chinese population through a systematic review and meta-analysis. METHODS A systematic literature search was conducted to find randomized, controlled trials in a Chinese population with at least two study arms-a control arm which receives a conventional, oral aminosalicylate drug, and a treatment arm, which administers the same conventional drug in conjunction with the probiotic Medilac-S~ per os. Both English and Chinese databases were searched, including Pub Med, EMBASE, Google Scholar, Chinese National Knowledge Infrastructure, Wanfang Data, and VIP Search, and study data was extracted onto standardized abstraction sheets. Meta-analyses were conducted for primary and secondary outcomes of interest using a fixed or random effects model. The primary outcome was the induction of clinical remission and the secondary outcomes included changes in Sutherland index, endoscopic and histological scores, proportion of reported clinical symptoms and adverse events(AEs). For outcomes with sufficient data, the type of conventional drug therapy was also assessed to determine if the effects of combination therapy with Medilac-S~ was influenced by drug type. All tests were conducted using a type Ⅰ error rate of 0.05 and all confidence intervals(CI) were based on a 95% confidence level. Review protocol was uploaded to PROSPERO(CRD42018085658 upon completion).RESULTS Fifty-three clinical trials with a total of 3984 participants were identified and included in the review. Medilac-S~ adjunctive therapy significantly improved induction of clinical remission(RR = 1.21; 95%CI: 1.18-1.24; P < 0.0001) with the estimated likelihood of effective treatment, on average, 21% higher for those consuming the probiotic. Sutherland index scores showed the control mean was on average 3.10(CI: 2.41-3.78; P = 0.0428) units greater than the treatment mean, thereby demonstrating significant improvement in participants taking the probiotic. Similarly, a significant difference was seen between the overall reduction of endoscopic and histological scores of control and treatment arm participants, with score decreases in the control groups 0.71(CI: 0.3537-1.0742) and 1.1(CI: 0.9189-1.2300) units smaller than treatment group score decreases. The proportion of participants reporting clinical symptoms,(abdominal pain, tenesmus, blood and mucous in stool, and diarrhea) was significantly reduced after combination therapy with Medilac-S~(P < 0.0001) and estimated to be on average 44%(RR = 0.44, CI: 0.32-0.59), 53%(RR = 0.53, CI: 0.38-74), 40%(RR = 0.40, CI: 0.28-0.58) and 47%(RR = 0.47 CI: 0.36-0.42) respectively, of the proportion of individuals reporting the aforementioned symptoms after conventional therapy alone. The risk of AEs was also significantly reduced with adjunctive Medilac-S~ therapy. The proportion of individuals in the treatment groups reporting AEs was an estimated 72% of the proportion of individuals in the control groups reporting AEs(RR = 0.72, CI: 0.55-0.94, P = 0.0175). Upon comparing effect means for different drug types in conjunction with Medilac-S~, evidence of significant variability(P < 0.0001) was observed, and sulfasalazine was found to be the most effective drug in both primary and secondary outcomes. CONCLUSION Evidence suggests Medilac-S~ adjunctive therapy should be considered standard care for UC in a Chinese population because it aids in the induction of clinical remission, improves symptoms of the gastrointestinal tract and reduces risk of AEs. | Ghania Sohail Xiaoyu Xu Mary C Christman Thomas A Tompkins | 2018 | World Journal of Clinical Cases2018，6，15： | 3 |
| 4 | The efficacy of small interfering RNAs targeted to the type 1 insulin-like growth factor receptor (IGF1R) is influenced by secondary structure in the IGF1R transcript显示文摘 | BOHULA E A SALISBURY A J SOHAIL M | 2003 | J Biol Chem2003，278，15： | 1 |
| 5 | Alleviation of cyclic heat stress in broilers by dietary supplementation of mannan oligosaccharide and Lactobacillus -based probiotic: dynamics of cortisol, thyroid hormones, cholesterol, C reactive protein, and humoral immunity 显示文摘 | Sohail M U Ijaz A Yousaf M S | 2010 | Poultry Science2010，89，9： | 1 |
| 6 | Alleviation of cyclic heat stress in broilers by dietary supplementation of mannao-oligosaccharide and Lactobacillus based probiotic :dynamics ofcortisol,thyroid hormones,cholesterol,C-reactive protein, an d humoral immunity显示文摘 | Sohail M U Ijaz A YousafM S | 2010 | Poultry S cience2010，89，： | 1 |
| 7 | Festival tourism in the United Arab Emirates: First-time versus repeat visitor perceptions显示文摘 | Anwar S A Sohail M S | 2004 | Journal of Vacation Marketing2004，10，2： | 1 |
| 8 | The use of third party logistics services: a Malaysian perspective 显示文摘 | SOHAIL M S SOHAL A S | 2003 | Technovation2003，23，5： | 1 |
| 9 | Utility of DNA methylation markers for diagnosing cancer 显示文摘 | QURESHI SOHAIL A MUHAMMED U B | 2010 | International Journal of Surgery2010，8，3： | 1 |
| 10 | Effect of supplementation of prebiotic mannan-oligosaccharides and probiotic mixture on growth performance of broilers subjected to chronic heat stress显示文摘 | SOHAIL M U HUME M E BYRD J A | 2012 | Poult Sci2012，91，9： | 1 |
| 11 | Role of anticoagulation in the management of pancreatic cancer显示文摘 | Sohail M A Saif M W | 2009 | J Pancreas2009，10，2： | 1 |
| 12 | Inflammasome-mediated regulation of hepatic stellate cells 显示文摘 | Watanabe A Sohail MA Gomes DA | 2009 | Am Gastrointest Liver Phvsiol2009，296，6： | 1 |
| 13 | Alleviation of cyclic heat stress in broilers by dietary supplementation of mannan-oligosac- charide and Lactobacillus-based probiotic: dynamics of cortisoI, thyroid hormones, cholesterol, C-reactive protein, and humoral immunity显示文摘 | Sohail M U Ijaz A Yousaf M S | 2010 | Poul Sci2010，89，9： | 1 |
| 14 | TLR9 and the NLRP3 inflammasome link acinar cell death with inflammation in acute pancreatitis显示文摘 | Hoque R Sohail M Malik A | | 0，，01： | 1 |
| 15 | The use of third party logistics services: a malaysian perspective显示文摘 | Sohail M S Sohal A S | 2003 | Technovation2003，23，4： | 1 |
| 16 | Effect of different levels of blood meal on broiler performance during two phases growth显示文摘 | Tabinda K Noor N A Sohail H K | 2007 | International Journal of Poultry Science2007，6，12： | 1 |
| 17 | Management of as- citesduetogastmintestinalmalignancy显示文摘 | Saif M W Siddiqui I A Sohail M A | 2009 | Ann Saudi Med2009，29，5： | 1 |
| 18 | Classification of Ultrasound Medical Images Using Distance Based Feature Selection and Fuzzy-SVM 显示文摘 | SOHAIL A S M BHATTACHARYA P MUDUR S P | 2011 | Pattern Recognition and Image Analysis2011，6669，1： | 1 |
| 19 | Product configuration,ambidexterity and firm performance in the context of industrialequipment manufacturing显示文摘 | Salvador F Chandrasekaran A Sohail T | 2014 | Journal of Operations Management2014，32，4： | 1 |
| 20 | Influence of supplemental phytase on performance of broilers four to six weeks of age 显示文摘 | Sohail S S Roland D A Roland S R | 1999 | Poult Sci1999，78，： | 1 |
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