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| 1 | Crosstalk of liver immune cells and cell death mechanisms in different murine models of liver injury and its clinical relevance显示文摘BACKGROUND: Liver inflammation or hepatitis is a result of pluripotent interactions of cell death molecules, cytokines, chemokines and the resident immune cells collectively called as microenvironment. The interplay of these inflammatory mediators and switching of immune responses during hepatotoxic, viral, drug-induced and immune cell-mediated hepatitis decide the fate of liver pathology. The present review aimed to describe the mechanisms of liver injury, its relevance to human liver pathology and insights for the future therapeutic interventions.DATA SOURCES: The data of mouse hepatic models and relevant human liver diseases presented in this review are systematically collected from Pub Med, Science Direct and the Web of Science databases published in English. RESULTS: The hepatotoxic liver injury in mice induced by the metabolites of CCl4, acetaminophen or alcohol represent necrotic cell death with activation of cytochrome pathway, formation of reactive oxygen species(ROS) and mitochondrial damage. The Fas or TNF-α induced apoptotic liver injury was dependent on activation of caspases, release of cytochrome c and apoptosome formation. The Con A-hepatitis demonstrated the involvement of TRAIL-dependent necrotic/necroptotic cell death with activation of RIPK1/3. The α-Gal Cer-induced liver injury was mediated by TNF-α. The LPS-induced hepatitis involved TNF-α, Fas/Fas L, and perforin/granzyme cell death pathways. The MHV3 or Poly(I:C) induced liver injury was mediated by natural killer cells and TNF-α signaling. The necrotic ischemia-reperfusion liver injury was mediated byhypoxia, ROS, and pro-inflammatory cytokines; however, necroptotic cell death was found in partial hepatectomy. The crucial role of immune cells and cell death mediators in viral hepatitis(HBV, HCV), drug-induced liver injury, non-alcoholic fatty liver disease and alcoholic liver disease in human were discussed.CONCLUSIONS: The mouse animal models of hepatitis provide a parallel approach for the study of human liver pathology. Blocking or stimulating the pathways associated with liver cell death could unveil the novel therapeutic strategies in the management of liver diseases. | Hilal Ahmad Khan Muhammad Zishan Ahmad Junaid Ali Khan Muhammad Imran Arshad | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，3： | 24 |
| 2 | 冬小麦抗倒春寒性能鉴定方法和指标的比较显示文摘倒春寒是限制黄淮冬麦区小麦稳产和丰产的主要因素之一,选育抗倒春寒小麦新品种是降低倒春寒危害的重要手段,建立简单易行、易推广且全面系统的小麦抗倒春寒性能鉴定方法和指标体系对保障粮食安全有着重要意义。本文系统总结了冬小麦抗倒春寒鉴定的方法和指标,进行了比较和评价,并提出鉴定原则和程序。(1)鉴定方法方面,主要包括直接鉴定法、间接鉴定法和综合鉴定法等,直接鉴定法有田间自然鉴定法(引种栽培应用最广,但周期长、工作量大)、人工模拟气候室法(周期短、可重复性强,但对设备与技术要求较高)和生长恢复法(冬前冻害鉴定较多,抗倒春寒鉴定方面较少,一般与其它鉴定方法配合使用)等;间接鉴定法有助倒春寒危害温度阈值的研究,但目前指标与抗寒性关系还未有明确定论,应用受到限制;综合鉴定法鉴定结果全面而准确,但对技术、成本要求较高且工作量较大。因此,在鉴定过程中要结合实际情况合理搭配、综合运用。(2)鉴定指标方面,主要包括形态与农艺、生理生化、气象与生态指标等,形态与农艺指标一般用于田间自然鉴定法,常以数量、质量、颜色和形态变化等作为参考项;生理生化指标一般用于间接鉴定法,包括活性氧、渗透调节物质、内源激素含量、抗氧化酶活性以及光合与呼吸特性等;气象与生态指标常应用于各种鉴定方法,气温、地温、冠层温度、半致死温度和恢复生长最低温度常作为鉴定指标,而光照、CO2、湿度和肥力等因素会影响结果准确性。(3)关于鉴定原则与程序,本文提出了鉴定结果的地域性、指标选用的针对性、鉴定方法与指标的综合性和实用性等鉴定原则,并以易灾期、品种敏感期、敏感器官、鉴定方法和指标、低温程度、田间/盆栽试验、数学分析方法、抗寒性能评价与分级为主要流程的鉴定程序。最后,从抗寒生理研究、新兴技术鉴定研究与应用和鉴定产品的研发等方面做了展望。 | 张乐乐 陈翔 柯媛媛 柳彬彬 Muhammad Ahmad Hassan 张妍 许辉 李金才 | 2021 | 中国农业气象2021，42，2： | 13 |
| 3 | 药隔期低温胁迫对小麦干物质积累、转运和分配及产量的影响显示文摘为探明药隔期低温胁迫对小麦产量的影响,以烟农19、新麦26为供试材料,在小麦药隔期进行不同程度(T1:2℃/4h、T2:0℃/4h、T3:–2℃/4h)的低温处理,研究药隔期低温胁迫对小麦干物质积累、转运和分配及产量的影响。结果表明:药隔期低温胁迫显著降低小麦干物质积累量,不同抗倒春寒性小麦品种间干物质积累量存在差异,抗倒春寒性弱的小麦品种降幅更大。其中烟农19的T1、T2、T3处理分别降低33.4%、46.2%和54.7%,而新麦26则分别降低了50.1%、59.3%和72.4%。不同处理小麦籽粒、穗轴+颖壳、茎鞘+叶的干物质积累量均低于CK,且随着低温胁迫程度的加重呈明显降低趋势。小麦花前干物质的转运量、转运效率以及花前贮藏干物质对籽粒的贡献率均随着低温胁迫程度加重呈降低趋势。同时低温胁迫显著降低小麦籽粒和穗轴+颖壳的干物质分配比例,增加茎鞘+叶的分配比例。T1、T2和T3处理显著降低了小麦的穗粒数和千粒重及籽粒产量,烟农19的T1、T2和T3处理分别减产56.06%、86.36%和98.10%;新麦26的T1、T2和T3处理分别减产96.15%、98.07%和98.46%。药隔期低温胁迫显著降低小麦干物质的积累量、花前干物质的转运量、转运效率以及花前贮藏干物质对籽粒的贡献率和籽粒干物质分配比例,严重减少光合同化物向穗部的转运和分配,影响穗部小花的正常发育,从而导致穗粒数的减少,这是造成小麦减产的主要原因。 | 柯媛媛 陈翔 张乐乐 张妍 许辉 Muhammad Ahmad Hassan 江港 林非非 魏凤珍 李金才 | 2021 | 安徽农业大学学报2021，48，5： | 12 |
| 4 | 行距对棉花生长发育、产量及早熟性指数的影响的研究(英文)显示文摘棉花窄行密植生产是缩短棉花生长季节实现棉花早熟的主要举措,并且窄行密植对棉花的产量无显著影响。田间试验于2006年6月到2007年1月在巴基斯坦费萨拉巴德农业大学试验田进行,以确定行距对不同品系棉花的生长、生产和早熟性指数的影响。试验选取NIAB-111,CIM-496和FH-901 3个棉花品种,设置了60、75和90 cm 3种行距进行试验研究。结果表明:行距对棉花生长发育、产量和早熟性指数具有极显著影响;行距75 cm的处理产量最高达到2603 kg·hm-2,其次是行距60 cm的处理,产量为2541 kg·hm-2,但二者间差异不显著;行距60 cm的处理早熟性指数达到50.92%,显著大于其它处理;行距75 cm的处理次之。子棉产量最高的品种是FH-901,同时其早熟性指数也最高,达到54.34%。 | ANJUM Shakeel Ahmad SALEEM Muhammad Farrukh 王龙昌 薛兰兰 SHAH ID Muhammad Qasim ALI Shafaqat | 2010 | 棉花学报2010，22，6： | 11 |
| 5 | Bibliometrics: tracking research impact by selecting Lhe appropriate metrics显示文摘 | Ashok Agarwal Damayanthi Durairajanayagam Sindhuja Tatagari Sandro C Esteves Avi Harlev Ralf Henkel Shubhadeep Roychoudhury Sheryl Homa Nicolas Garrido Puchalt Ranjith Ramasamy Ahmad Majzoub Kim Dao Ly Eva Tvrda Mourad Assidi Kavindra Kesai Reecha Sharma Saleem Banihani Edmund Ko Muhammad Abu-Elmagd Jaime Gosalvez Asher Bashiri | 2016 | Asian Journal of Andrology2016，18，2： | 10 |
| 6 | Bulk and bubble-scale experimental studies of influence of nanoparticles on foam stability显示文摘Influence of silicon oxide(SiO_2) and aluminum oxide(Al_2O_3) nanoparticles on the stability of nanoparticles and sodium dodecyl sulfate(SDS) mixed solution foams was studied at bulk and bubble-scale. Foam apparent viscosity was also determined in Hele-Shaw cell In order to investigate the foam performance at static and dynamic conditions. Results show that the maximum adsorption of surfactant on the nanoparticles occurs at 3 wt% surfactant concentration. Foam stability increases while the foamability decreases with the increasing nanoparticle concentration. However, optimum nanoparticle concentration corresponding to maximum foam stability was obtained at 1.0 wt% nanoparticle concentration for the hydrophilic SiO_2/SDS and Al_2O_3/SDS foams. Foam performance was enhanced with increasing nanoparticles hydrophobicity. Air-foams were generally more stable than CO_2 foams.Foam apparent viscosity increased in the presence of nanoparticles from 20.34 mPa·s to 84.84 mPa·s while the film thickness increased from 27.5 μm to 136 μm. This study suggests that the static and dynamic stability of conventional foams could be improved with addition of appropriate concentration of nanoparticles into the surfactant solution. The nanoparticles improve foam stability by their adsorption and aggregation at the foam lamellae to increase film thickness and dilational viscoelasticity. This prevents liquid drainage and film thinning and improves foam stability both at the bulk and bubble scale. | Nurudeen Yekeen Ahmad Kamal Idris Muhammad A.Manan Ali Mohamed Samin Abdul Rahim Risal Tan Xin Kun | 2017 | Chinese Journal of Chemical Engineering2017，25，3： | 9 |
| 7 | Farmers' Perception and Awareness and Factors Affecting Awareness of Farmers Regarding Crop Insurance as a Risk Coping Mechanism Evidence from Pakistan显示文摘This study has been conducted in three districts of Punjab Province namely, Dera Ghazi Khan, Rajan Pur and Bahawalpur of Pakistan. The study showed the results of a survey of 300 farmers which was organized to assess awareness level of farmers regarding crop insurance, factors affecting the awareness level among farmers and the perception of farmers about crop insurance. Based on exploratory research work upon the responses of farmers, the average and standard deviation were calculated. Probit model was applied to explore the factors affecting the awareness level of farmers. SPSS was used for the analysis of the collected data. The results revealed that out of 300 farmers, 184 farmers were aware with crop insurance and rests of the 116 farmers were not aware. Banks and E-media were found to be the two most important sources of the awareness for the respondent farmers. In the study area, the climatic risks were reported as the most severe risks faced by the farmers. The results also revealed the existence of negative perceptions of the farmers about crop insurance i.e. farmers perceived crop insurance as a kind of tax and they believed premium was so high that it was out of range of poor farmers and only large scale farmers could afford it. Results obtained by applying Probit model revealed that 'education' and 'previously availed agricultural credit' were the two most important factors which affected the awareness of the farmers regarding crop insurance. | Sidra Ghazanfar Zhang Qi-wen Muhammad Abdullah Zeeshan Ahmad Majid Lateef | 2015 | Journal of Northeast Agricultural University(English Edition)2015，22，1： | 9 |
| 8 | Psychophysiological Effects of Bamboo Plants on Adults显示文摘The present study was conducted to clarify the psychophysiological relaxation effects of viewing bamboo on university students. Forty healthy Chinese participants enrolled in this study to clarify the psychophysiological relaxation effects of viewing bamboo. The effects of visual stimulation using a pot both with and without a bamboo were recorded by measuring the student's blood pressure, EEG and STAI. We observed that viewing bamboo plants resulted in significantly lower systolic(female, P < 0.001; male, P < 0.001; P < 0.05) and diastolic(female,P < 0.001; male, P < 0.001; P < 0.05) blood pressures, but no changes in the pulse rate(female, P = 0.09; male, P = 0.07; P > 0.05) were observed. The results of the EEG analysis indicated brainwave variation(all P < 0.05) and lower anxiety scores(P < 0.01) after 3 min of viewing bamboo compared with the control. These findings indicate that visual stimulation with bamboo plants induced psychophysiological relaxation effects on adults. | Ahmad Hassan CHEN Qi Bing JIANG Tao LYU Bing Yang LI Nian LI Shu SHANGGUAN Zi Yue LI Yun Ting JUN Zhou Li LUO Qian CHEN Xin Yi WANG Yi Yan ZENG Cheng Cheng YANG Jun Muhammad Sohaib Tahir | 2017 | Biomedical and Environmental Sciences2017，30，11： | 8 |
| 9 | Bread wheat varieties as influenced by different nitrogen levels显示文摘 | HUSSAIN Iqtidar KHAN Muhammad Ayyaz KHAN Ejaz Ahmad | 2006 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2006，7，1： | 8 |
| 10 | Effects of uniconazole with or without micronutrient on the lignin biosynthesis,lodging resistance,and winter wheat production in semiarid regions显示文摘Lodging stress results in grain yield and quality reduction in wheat. Uniconazole, a potential plant growth regulator significantly enhances lignin biosynthesis and thus provides mechanical strength to plants in order to cope with lodging stress. A field study was conducted during the 2015–2016 and 2016–2017 growing seasons, to investigate the effects of uniconazole sole application or with micronutrient on the lignin biosynthesis, lodging resistance, and production of winter wheat. In the first experiment, uniconazole at concentrations of 0(CK), 15(US1), 30(US2), and 45(US3) mg L^-1 was applied as sole seed soaking, while in the second experiment with manganese(Mn) at concentration of 0.06 g L^-1 Mn, 0.06 g L^-1 Mn+ 15 mg L^-1 uniconazole(UMS1), 0.06 g L^-1 Mn+30 mg L^-1 uniconazole(UMS2), and 0.06 g L^-1 Mn+45 mg L^-1 uniconazole(UMS3), respectively. Uniconazole sole application or with micronutrient significantly increased the lignin content by improving the lignin-related enzyme activities of phenylalanine ammonia-lyase, cinnamyl alcohol dehydrogenase, tyrosine ammonialyase, and peroxidase, ameliorating basal internode characteristics, and breaking strength. The spike length, spike diameter, spikes/plant, weight/spike, yield/spike, and grain yield increased and then decreased with uniconazole application at a higher concentration, where their maximum values were recorded with UMS2 and US2 treatments. The lignin accumulation was positively correlated with lignin-related enzyme activities and breaking strength while, negatively correlated with lodging rate. Uniconazole significantly improved the lignin biosynthesis, lodging resistance, and grain yield of winter wheat and the treatments which showed the greatest effects were uniconazole seed soaking with micronutrient at a concentration of 30 mg L^-1 and 0.06 g L^-1 , and uniconazole sole seed soaking at a concentration of 30 mg L^-1 . | Irshad AHMAD MENG Xiang-ping Muhammad KAMRAN Shahzad ALI Shakeel AHMAD LIU Tie-ning CAI Tie HAN Qing-fang | 2020 | Journal of Integrative Agriculture2020，19，1： | 8 |
| 11 | Visual object tracking- classical and contemporary approaches显示文摘 | Ahmad ALI Abdul JALIL Jianwei NIU Xiaoke ZHAO Saima RATHORE Javed AHMED Muhammad AKSAM IFTIKHAR | 2016 | Frontiers of Computer Science2016，10，1： | 7 |
| 12 | Dual-specificity phosphatase 6(DUSP6): a review of its molecular characteristics and clinical relevance in cancer显示文摘Mitogen-activated protein kinases(MAPKs) are the main regulators of cellular proliferation, growth, and survival in physiological or pathological conditions. Aberrant MAPK signaling plays a pivotal role in carcinogenesis, which leads to development and progression of human cancer. Dual-specificity phosphatase 6(DUSP6), a member of the MAPK phosphatase family, interacts with specifically targeted extracellular signal-regulated kinase 1/2 via negative feedback regulation in the MAPK pathway of mammalian cells. This phosphatase functions in a dual manner, pro-oncogenic or tumor-suppressive, depending on the type of cancer. To date, the tumor-suppressive role of DUSP6 has been demonstrated in pancreatic cancer, non-small cell lung cancer, esophageal squamous cell and nasopharyngeal carcinoma, and ovarian cancer. Its pro-oncogenic role has been observed in human glioblastoma, thyroid carcinoma, breast cancer, and acute myeloid carcinoma. Both roles of DUSP6 have been documented in malignant melanoma depending on the histological subtype of the cancer. Loss-or gain-of-function effects of DUSP6 in these cancers highlights the significance of this phosphatase in carcinogenesis. Development of methods that use the DUSP6 gene as a therapeutic target for cancer treatment or as a prognostic factor for diagnosis and evaluation of cancer treatment outcome has great potential. This review focuses on molecular characteristics of the DUSP6 gene and its role in cancers in the purview of development, progression, and cancer treatment outcome. | Muhammad Khairi Ahmad Nur Ainina Abdollah Nurul Husna Shafie Narazah Mohd Yusof Siti Razila Abdul Razak | 2018 | Cancer Biology & Medicine2018，15，1： | 6 |
| 13 | e-antigen-negative chronic hepatitis B in Bangladesh显示文摘BACKGROUND:Bangladesh is a densely populated country where about 10 million people are chronically infected with hepatitis B virus(HBV).The aim of the present study was to evaluate the biochemical,virological and histological characteristics of HBeAg-negative chronic hepatitis B(CHB). METHODS:Patients were included in this study if they were chronically infected with HBV with detectable DNA.The patients who were co-infected with human immunodeficiency virus,hepatitis delta virus or hepatitis C virus,and previously subjected to antiviral treatment,and those with hepatocellular carcinoma were excluded.The study was conducted during the period of January 2001 to December 2007.During this period 2617 patients with CHB were studied.HBeAg-positive cases were included to compare the characteristics.Among them,237 cases underwent liver biopsy. RESULTS:2296 patients(87.7%)were male,with a mean age of 28.9±13.7 years.2375 patients(90.8%)had CHB,and 242(9.2%)were cirrhotic.HBV DNA levels were 7.6±1.5 copies/ml,ALT was 111.3±212.5 U/L,and AST was 91.5± 148.9 U/L.The number of HBeAg-negative CHB cases was 1039(39.7%).HBeAg-negative patients with a lower DNA load were older,and they had more fibrotic changes in the liver than HBeAg-positive patients.The two groups did not differ in necroinflammatory activity,but the former had lower ALT and AST values.Cirrhosis was more common in e-antigen-negative patients.CONCLUSIONS:e-antigen-negative CHB patients are older and have more hepatic fibrosis patients than HBeAg-positive patients,although they have similar necroinflammatory activity. | Nooruddin Ahmad Shahinul Alam Golam Mustafa Abul Barkat Muhammad Adnan Rahat Hasan Baig Mobin Khan | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，4： | 6 |
| 14 | Sludge granulation and efficiency of phase separator in UASB reactor treating combined industrial effluent显示文摘污泥使成粒状和 gas-liquid-solid 的效果隔板(图文集) designon upflow 的效率厌氧的污泥毛毯( UASB )和 upflow 厌氧的 sludgefilter ( UASF )反应堆,在从 3~12 h 的 HRT 操作 investigated.VSS/TS ratiogradually 在两个被增加有增加污泥的反应堆变老(从 0.5 到超过 0.7 forUASB 反应堆并且 0.012~0.043 为 UASF 反应堆) UASF sludgeshowed 的.X光线衍射分析扩展揭示它的另外的 abs | Abdullah Yasar Nasir Ahmad Muhammad Nawaz Chaudhry Aamir Amanat Ali Khan | 2007 | Journal of Environmental Sciences2007，19，5： | 6 |
| 15 | Order selection in fractional Fourier transform based beamforming显示文摘Traditionally,beamforming using fractional Fourier transform(FrFT) involves a trial-and-error based FrFT order selection which is impractical.A new numerical order selection scheme is presented based on fractional power spectra(FrFT moment) of the linear chirp signal.This method can adaptively determine the optimum FrFT order by maximizing the second-order central FrFT moment.This makes the desired chirp signal substantially concentrated whereas the noise is rejected considerably.This improves the mean square error minimization beamformer by reducing effectively the signal-noise cross terms due to the finite data length de-correlation operation.Simulation results show that the new method works well under a wide range of signal to noise ratio and signal to interference ratio. | Muhammad Ishtiaq Ahmad | 2010 | Journal of Systems Engineering and Electronics2010，21，3： | 5 |
| 16 | Protein Phosphorylation and Phosphoproteome:An Overview of Rice显示文摘Protein phosphorylation,one of the major post-translational modifications,plays a crucial role in cell signaling,DNA replication,gene expression and differentiation;and alters enzyme activity and other biological activities;and regulates cell proliferation and enlargement,phytohormone biosynthesis and signaling,plant disease resistance,and grain filling and quality during rice seed development.Research work on protein phosphorylation started in the 1950 s with the discovery of phosphorylase a and phosphorylase b which are phospho and dephospho forms of the same enzyme.Over the last decade,rice proteomics has accomplished tremendous progress in setting up techniques to proteome nearly all tissues,organs and organelles.The progress made in this field is evident in number of research works.However,research on rice protein phosphorylation is still at its infancy and there are still many unanswered questions.In this review,the general description of protein phosphorylation,including history,structure,frequency of occurrence and function,are discussed.This work also elucidates the different methods for identification,qualification and finally,the progress in rice phosphoproteome research and perspectives. | Abolore Adijat AJADI Amara CISSE Shakeel AHMAD WANG Yifeng SHU Yazhou LI Shufan LIU Xixi Babatunde Kazeem BELLO Sani Muhammad TAJO TONG Xiaohong ZHANG Jian | 2020 | Rice science2020，27，3： | 5 |
| 17 | Electrochemical CO_(2) reduction to C_(2+) products using Cu-based electrocatalysts:A review显示文摘With the disruptive carbon cycle being blamed for global warming,the plausible electrocatalytic CO_(2)reduction reaction(CO_(2)RR)to form valuable C_(2+)hydrocarbons and feedstock is becoming a hot topic.Cu-based electrocatalysts have been proven to be excellent CO_(2)RR alternatives for high energy value-added products in this regard.However,the selectivity of CO_(2)RR to form C_(2+)products via Cu-based catalysts suffers from a high overpotential,slow reaction kinetics,and low selectivity.This review attempts to discuss various cutting-edge strategies for understanding catalytic design such as Cu-based catalyst surface engineering,tuning Cu bandgap via alloying,nanocatalysis,and the effect of the electrolyte and pH on catalyst morphology.The most recent advances in in situ spectroscopy and computational techniques are summarized to fully comprehend reaction mechanisms,structural transformation/degradation mechanisms,and crystal facet loss with subsequent effects on catalyst activity.Furthermore,approaches for tuning Cu interactions are discussed from four key perspectives:single-atom catalysts,interfacial engineering,metal-organic frameworks,and polymer-incorporated materials,which provide new insights into the selectivity of C_(2+)products.Finally,major challenges are outlined,and potential prospects for the rational design of catalysts for robust CO_(2)RR are proposed.The integration of catalytic design with mechanistic understanding is a step forward in the promising advancement of CO_(2)RR technology for industrial applications. | Touqeer Ahmad Shuang Liu Muhammad Sajid Ke Li Mohsin Ali Liang Liu Wei Chen | 2022 | Nano Research Energy2022，1，2： | 5 |
| 18 | Algal biomass as a global source of transport fuels:Overview and development perspectives显示文摘As a result of the global fuel crisis of the early 1970 s,coupled with concerns for the environment,the use of biofuel has been on the increase in many regions throughout the world.At present,a total of approximately 30 billion(30×109) liters of biofuel are utilized worldwide annually,although most countries rely hugely on the first generation biofuel.The limitations of the first and second generation biofuel gave rise to current interest in algae as a promising alternative to these conventional biofuel sources.Algal biomass could provide a lion's share of the global transport fuel requirements in future.The present review highlights some important developments in,and potentials of algaculture as a major biomass resource of the future.However,the major constraint to commercial-scale algae farming for energy production is the cost factor,which must be addressed adequately before its potentials can be harnessed. | Kifayat Ullah Mushtaq Ahmad Sofia Vinod Kumar Sharma Pengmei Lu Adam Harvey Muhammad Zafar Shazia Sultana C.N.Anyanwu | 2014 | Progress in Natural Science:Materials International2014，24，4： | 5 |
| 19 | Apoptosis,antimicrobial and antioxidant activities of phytochemicals from Garcinia malaccensis Hk.f显示文摘Objective:To study the chemical constituents of stembark of Garcinia malaccenm(G.malaccenm) together with apoptotic.antimicrobial and antioxidant activities.Methods:Purification and structure elucidation were carried out by chromatographic and spectroscopic techniques, respectively.MTT and trypan blue exclusion methods were performed to study the cytotoxic activity.Antibacterial activity was conducted by dise diffusion and microdilulion methods, whereas antioxidant activities were done by ferric thiocyanate method and DPPH radical scavenging.Results:The phylochemical study led lo the isolation ofα,β-mangostin and cycloarl-24-en-3β-ol.α-Mangostin exhibited cytotoxic activity against HSC-3 cells with an IC50 of 0.33μM.β- andα-mangostin showed activity against K562 cells with IC50 of 0.40μM and 0.48μM,respectively,α-Mangostin was active against Gram-positive bacteria, Staphylococcus aureus(S.aureus) and Bacilus anthracis(B.anthmcis) with inhibition zone and MIC value of(19 mm;0.02S mg/mL) and(20 mm;0.013 mg/mL),respectively.In antioxidant assay,α-mangostin exhibited activity as an inhibitor of lipid peroxidation.Conclusions:G.malaccenm presenceα- andβ-mangostin and cycloart-24-en-3β-ol.β-Mangostin was found very active against H.SC-3 cells and KS62.The results suggest that mangoslins derivatives have the potential to inhibit the growth of cancer cells by inducing apoptosis.In addition,α-andβ-mangostin was found inhibit the growth of Cram-positive pathogenic bacteria and also showed the activity as an inhibitor of lipid peroxidation. | Muhammad Taher Deny Susanti Mohamad Fazlin Rezali Farah Syahidah Ahmad Zohri Solachuddin Jauhari Arief Ichwan Suhaib Ibrahim Alkhamaiseh Farediah Ahmad | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，2： | 5 |
| 20 | Synergistic antibacterial effect of honey and Herba Ocimi Basilici against some bacterial pathogens显示文摘OBJECTIVE: To evaluate the antibacterial activity of the combination of different honey brands and methanolic fraction of Herba Ocimi Basilici using agar well diffusion assay. METHODS: The antibacterial activity was determined against thirteen pathogenic bacterial clinical isolates including six gram negative(Klebsiella pneumonia, Pseudomonas aeroginosa, Escherichia coli, Salmonella typhi, Salmonella typhimirium, Xanthomonas campestris) and six gram positive strains(Enterococcus faecalis faecalis, Bacillus subtilis, Staphylococcus aureus, Clostridium perfringens type C, Clostridium perfringens type D, Clostridium chauvoei). Agar well diffusion method was used while zones of inhibition were measured with vernier scale. RESULTS: At higher concentration, all the honey brands showed good to significant activity. The highest activity was observed for Hamdard brand honey(27.60±0.40) against Enterococcus faecalis. CONCLUSION: These results revealed that combinations of plant extracts of Herba Ocimi Basilici with honey can be used for the development of potent and novel antibacterial agents. | Ali Talha Khalil Imran Khan Kafeel Ahmad Yusra Ali Khan Momin Khan Muhammad Jaseem Khan | 2013 | Journal of Traditional Chinese Medicine2013，33，6： | 4 |
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