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| 1 | 7核苷酸切除修复交叉互补集团1蛋白表达预测晚期头颈癌患者对诱导化疗的客观应答及生存率显示文摘该文旨在评价核苷酸切除修复交叉互补集团1(ERCC1)的表达与基于铂类诱导化疗的晚期头颈癌患者癌症生存专率的关系。对1992—1996年间的107例行诱导化疗的晚期头颈鳞癌患者进行研究.其中96例存在活检样本。对组织切片行ERCC1蛋白免疫组化染色,双盲法评价蛋白的表达。结果,68例(71%)存在ERCC1蛋白强阳性表达,28例(29%)为低表达。Logistic回归分析显示.蛋白低表达者对化疗的敏感性较高表达者高4倍(P=0.01)。 | Handra-Luca A Hernandez J Mountzios G | 2007 | 中国口腔颌面外科杂志2007，5，5： | 13 |
| 2 | Optimal management of the elderly patient with head and neck cancer: Issues regarding surgery, irradiation and chemotherapy显示文摘Head and neck cancer(HNC) represents the sixth most common malignancy and accounts for approximately 6% of new cancer cases annually worldwide. As life expectancy constantly increases, the onset of HNC in patients older than 65 years of age at diagnosis is not rare and up to one fourth of cases occurs in patients older that 70 years at age. Because elderly cancer patients are severely under-represented in clinical trials, there is a clear need to address the particular aspects of this specific patient group, especially in the context of novel multidisciplinary therapeutic approaches. The frailty of elderly patients with HNC is attributed to the high incidence of smoking and alcohol abuse in this malignancy and the presence of substantial cardiovascular, respiratory or metabolic comorbidities. In the current work, I provide an overview of current and emerging treatment approaches, in elderly patients with HNC. In particular, I discuss modern surgical approaches that improve radical excision rates while preserving functionality, the incorporation of modern radiotherapeutic techniques and the introduction of novel chemotherapeutic combinations and molecular targeted agents in an effort to reduce toxicity without compromising efficacy. Finally, there is an urgent need to increase accrual and active participation of elderly patients with HNC in clinical trials, including biomarker evaluation in biopsy specimens towards an individualized therapeutic approach. | Giannis Mountzios | 2015 | World Journal of Clinical Oncology2015，6，1： | 3 |
| 3 | Abnormal bone remodeling process is due to an imbalance in the receptor activator of nuclear factor -kappa B ligand (RANKL)/ osteoprotegerin (OPG) axis in patients with solid tumors metastatic to the skeleton显示文摘 | Mountzios G Dimopoulos MA Bamias A | 2007 | Acta Oncol2007，46，2： | 1 |
| 4 | Developments in the systemic treatment of endometrial cancer显示文摘 | mountzios g Pectasides d Bournakis E | 2011 | Crit Rev Oncol Hematol2011，79，3： | 1 |
| 5 | Aurora kinases as targets for cancer therapy显示文摘 | Mountzios G Terpos E Dimopoulos MA | 2008 | Cancer Treat Rev2008，34，2： | 1 |
| 6 | ERCC1 as a risk stratifier inplatinum-based chemotherapy for nonsmall-cell lung cancer显示文摘 | Olaussen KA Mountzios G Soria JC | 2007 | CurrOpin Pulm Med2007，13，4： | 1 |
| 7 | ERCC1 as a riskstratifier in platinum-based chemotherapy for nonsmall-cell lung cancer显示文摘 | Olaussen KA Mountzios G Soria JC | 2007 | Curr Opin Pulm Med2007，13，4： | 1 |
| 8 | Excision Repair Cr-oss-Complementation Group 1 Enzyme as a Molecular Determinant ofResponsiveness to Platinum-Based Chemotherapy for non Small-CellLung Cancer显示文摘 | Mountzios G Dimopoulos MA Papadimitriou C | 2008 | Biomark Insights2008，3，： | 1 |
| 9 | Mechanisms of- disease: signal transduction in lung comparison of smokers and never-smokers 显示文摘 | MOUNTZIOS G FOURET P SORIA J C | 2008 | Nat Clin Pract Oncol2008，5，10： | 1 |
| 10 | Markers of bone remodeling and skeletal morbidity in patients with solid tumors metastatic to the skeleton receiving the biphosphonate zoledronic acid显示文摘 | Mountzios G Terpos E Syrigos K | | 0，，05： | 1 |
| 11 | Paclitaxel plus bevacizumab in patients with chemoresistant relapsed small cell lung cancer as salvage treatment:a phase Ⅱ multicenter study of the Hellenic Oncology Research Group显示文摘 | Mountzios G Emmanouilidis C Vardakis N | 2012 | Lung Cancer2012，77，1： | 1 |
| 12 | Mitogen-activated protein kinase activation in lung adenocarcinoma:a comparative study between ever smokers and never smokers显示文摘 | Mountzios G Planchard D Besse B | | 0，，： | 1 |
| 13 | Paclitaxel plus bevacizumab in patients with chemoresistant relapsed small cell lung cancer as salvage treatment: a phase ]] muhicenter study of the Hellenic Ontology Research Group 显示文摘 | Mountzios G Emmanouilidis C Vardakis N | 2012 | Lung Cancer2012，77，1： | 1 |
| 14 | Random- ized muhicenter phase Ⅱ trial of cisplatin and ifosfamide with or without paclitaxel in recurrent or metastatic carcinoma of the uterine cervix: a Hellenic Cooperative Oncology Group (HeCOG) study显示文摘 | Mountzios G Dimopoulos MA Bamias A | 2009 | Ann Onco!2009，20，8： | 1 |
| 15 | Abnormal bone remodeling process is due to an imbalance in the receptor activator of nuclear factor-kappaB ligand(RANKL)/osteoprotegerin(OPG) axis in patients with solid tumors metastatic to the skeleton显示文摘 | Mountzios G Dimopoulos MA Bamias A | 2007 | Acta Oncol2007，46，2： | 1 |
| 16 | Abnormal bone re- modeling process is due to an imbalance in the receptor activator of nuclear factor-kappaB ligand(RANKL)/osteoprotegerin(OPG) axis in patients with solid tumors metastatic to the skeleton显示文摘 | Mountzios G Dimopoulos MA Bamias A | 2007 | Acta 0n- col2007，46，2： | 1 |
| 17 | Prognostic significance of bone markers in patients with lung cancer metastatic to the skeleton:a review of published data显示文摘 | Mountzios G Ramfidis V Terpos E | 2011 | Clin Lung Cancer2011，12，6： | 1 |
| 18 | All about KRAS for clinical oncology practice: Gene profile, clinical implications and laboratory recommendations for somatic mutational testing in colorectal cancer显示文摘 | Helena Linardou Evangelos Briasoulis Issa J. Dahabreh Giannis Mountzios Christos Papadimitriou Savvas Papadopoulos Dimitrios Bafaloukos Paris Kosmidis Samuel Murray | 2010 | Cancer Treatment Reviews2010，，3： | 1 |
| 19 | A benefit-risk assessment of erlotinib in non-small-cell lung cancer and pancreatic cancer显示文摘 | Mountzios G Syrigos KN | 2011 | Drug Saf2011，34，3： | 1 |
| 20 | Paclitaxel plus bevacizumab in patients with chemoresistant relapsed small cell lung cancer as salvage treatment: a phase II multicenter study of the Hellenic Ontology Research Group 显示文摘 | Mountzios G Emmanouilidis C Vardakis N | 2012 | Lung Cancer2012，77，1： | 1 |
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