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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Study of the effect of annealing on defects in Fe-Mn-Si-Cr-Ni-C alloy by slow positronbeam显示文摘 | Khaled M Mostafa Baerdemaeker J De Caenegem N Van | 2008 | Applied Surface Science2008，255，1： | 1 |
| 3 | Prestressed Concrete Piles in J0intless Bridges 显示文摘 | Kamel M R Benak J V Tadros M K Mostafa J | 1996 | PCI Journal1996，41，2： | 1 |
| 4 | Prediction of standard heats and Gibbs free energies formation of solid inorganic salts from group contributions显示文摘 | Mostafa A T M G Eakman J M Yarbro S L | | 0，，12： | 1 |
| 5 | City Develop- ment strategies (CDS) and sustainable urbanization in develo- ping world 显示文摘 | MOSTAFA S R NURWATI B MASTURA J | 2012 | Social and Behavioral Sciences2012，，36： | 1 |
| 6 | Effects of interleukin-10 on monocyte/endothelial cell adhesion and MMP-9/TIMP-1 secretion显示文摘 | Mostafa M Sylvie CM Mounia O Nathalie L Marie-Paule J Jean-Baptiste M | 2001 | Cardiovasc Res2001，49，4： | 1 |
| 7 | Acute alterations in microvascular basal lamina after subarachnoid hemorrhage显示文摘 | Mostafa G Knopman J | 2004 | J Neurosurg2004，101，： | 1 |
| 8 | Gene ontology annotation as text categorization:An empirical study显示文摘 | Seki K Mostafa J | 2008 | Inf Process Manag2008，44，5： | 1 |
| 9 | Acute alterations in microvascular basal lamina after subarachnoid hemorrhage 显示文摘 | Sehba FA Mostafa G Knopman J | 2004 | J Neurosurg2004，101，4： | 1 |
| 10 | Effect of temperature and relative humidity on the cellular defense response of Ephestia kuehniella larvae fed Bacillus thuringiensis显示文摘 | MOSTAFA A M FIELDS P G HOLLIDAY N J | 2005 | Journal of Invertebrate Pathology2005，90，： | 1 |
| 11 | Iterative algebraic softdecision list decoding of Reed-Solomon codes显示文摘 | Mostafa El-Khamy Robert J McEliece | 2006 | IEEE Journal on Selected Areasin Communication2006，24，3： | 1 |
| 12 | Edge-detection method using binary morphology on hexagonal images显示文摘 | Mostafa K Chiang J Y Her I | 2015 | The Imaging Science Journal2015，63，3： | 1 |
| 13 | A multilevel approach to intelligent information filtering:model,system,and evaluation显示文摘 | MOSTAFA J LAM S W PALAKAL M | 1997 | ACM Transactions on Information Systems1997，15，4： | 1 |
| 14 | A new semi-analytical model for prediction of the strand surface temperature in the continuous casting of steel in the mold region 显示文摘 | Mostafa A Ahmad J J Omid A | 2008 | ISIJ International2008，48，2： | 1 |
| 15 | Automatic classification using supervised learning in a medical document filtering application显示文摘 | Mostafa J Lam W | 2000 | Information Processing and Management2000，36，： | 1 |
| 16 | Glassy nature of water in an ultracomfining disorderedmaterial:the case of calcium-silicate-hydrate显示文摘 | Youssef Mostafa Pellenq Roland J M Yildiz Bilge | 2011 | J AmChem Soc2011，133，： | 1 |
| 17 | Call admission control based on adaptive bandwidth allocation for wireless networks显示文摘 | MOSTAFA Z C YEONG M J ZYGMUNT J H | 2013 | Journal of Communications and Networks2013，15，1： | 1 |
| 18 | Modeling user interest shift using a Bayesian approach 显示文摘 | Lam W Mostafa J | 2001 | Journal of the American society for Information Science and Technology2001，52，5： | 1 |
| 19 | Automatic classification using supervised lear-ning in a medical document filtering application显示文摘 | MOSTAFA J LAM W | 2000 | Information Processing and Management2000，36，3： | 1 |
| 20 | The statistical performance of the music and the minimumnorm algorithms in resolving plane waves in noise显示文摘 | MOSTAFA K ARTHUR J B SHAN Tiejun | | 0，，04： | 1 |
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