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| 1 | Predictive markers of endocrine response in breast cancer显示文摘Ongoing clinical and research efforts seek to optimise the use of endocrine therapy in the treatment of breast cancer. Accurate biomarkers are needed that predict response for individual patients. The presence of the estrogen receptor(ER) as the direct(for tamoxifen and fulvestrant) or indirect(for aromatase inhibitors) target molecule for endocrine therapy remains the foremost biomarker and determinant of response. However, ER expression only poorly predicts outcome and further indicators of response or resistance are required. The development and application of molecular signature assays such as Oncotype Dx, Prosigna, Mammaprint and Endopredict have provided valuable information on prognosis and these are being used to support clinical decision making on whether endocrine therapy alone alongside surgery is sufficient for ER-positive early stage breast cancers or whether combination of endocrine with chemotherapy are also warranted. Ki67, the proliferation marker, has been widely used in the neo-adjuvant(pre-operative) setting to help predict response and long term outcome. Gene expression studies within the same setting have allowed monitoring of changes of potential predictive markers. These have identified frequent changes in estrogenregulated and proliferation genes. Specific molecules such as mutant ER may also prove helpful biomarkers in predicting outcome and monitoring response to treatment. | Duniya Mosly Arran Turnbull Andrew Sims Carol Ward Simon Langdon | 2018 | World Journal of Experimental Medicine2018，8，1： | 2 |
| 2 | Shock wave lithotripsy in patients with renal calculi显示文摘 | Tayib AM Mosli HA Farsi HM | 2008 | Saudi Med J2008，29，8： | 1 |
| 3 | A Saudi Gastroenterology association position statement on the use of tumor necrosis factor-alfa antagonists for the treatment of inflammatory bowel disease显示文摘 | Mahmoud Mosli Othman Al-Harbi Brian Feagan Majid Almadi | 2015 | Saudi Journal of Gastroenterology2015，，4： | 1 |
| 4 | Vesicoureteral reflux in patients with double pigtail stents 显示文摘 | Farsi HMA Al-zimaity MF | 1991 | J Urol1991，146，： | 1 |
| 5 | Prostate inflammation association with benign prostatic hyperplasia and prostate cancer 显示文摘 | Abdel-Meguid TA Mosli HA Al-Maghrabi JA | 2009 | Saudi Med J2009，30，12： | 1 |
| 6 | Retrospective analysis of disease associa- tion and outcome in histologically confirmed ischemic colitis显示文摘 | Mosli M Parfitt J Gregot J | 2013 | J Dig Dis2013，14，5： | 1 |
| 7 | Shock wave lithotripsy in patients with renal calculi显示文摘 | Tayib AM Mosli HA Farsi HM | 2008 | Saudi Med J2008，29，8： | 1 |
| 8 | Modulatoryeffect of silymarin on inflammatory mediators inexperimentally induced benign prostatic hyperplasia :emphasis on PTEN, HIF-lalpha, and NF-kappaB显示文摘 | Atawia R T Mosli H H Tadros M G | 2014 | Naunyn Schmiedebergs Arch Pharmacol2014，387，12： | 1 |
| 9 | C-reactive protein, fecal calprotectin, and stool lactoferrin for detection of endoscopic activity in symptomatic inflammatory bowel disease patients: a systematic review and meta-analysis显示文摘 | Mosli MH Zou G Garg SK | 2015 | Am J Gastroenterol2015，110，6： | 1 |
| 10 | Endourethrotomy of posterior urethral obliterations and severe strictures: improved outcome with urethral self-dilatation显示文摘 | Mosli H Farsi HM | 1996 | J Endourol1996，10，4： | 1 |
| 11 | Shock wave lithotripsy in patients with renal calculi显示文摘 | Tayib AM Mosli HA Farsi HM | 2008 | Saudi Med J2008，29，8： | 1 |
| 12 | Separation of the N-7 methyltransferase,the key enzyme in caffeine biosynthesis 显示文摘 | Mosli Waldhauser S S Gillies F M Crozier A Baumans T W | 1997 | Phytochemistry1997，45，7： | 1 |
| 13 | Effect of transitory water stress on potato tuber stem-end reducing sugar and fry color显示文摘 | Eldredge E P Holmes Z A Mosly A R | 1996 | American Journal of Potato Research1996，73，11： | 1 |
| 14 | Endoureth - rotomy of posterior urethral obliterations and severe strictures: improved outcome with urethralself - dilata - tion显示文摘 | Alzimaity MF Mosli H Farsi HM | 1996 | Endourol1996，10，： | 1 |
| 15 | In situ extracorporeal shock wave lithoripsy for primary ureteric calculi显示文摘 | Fars H M Mosli H A Alzimaity M | 1994 | Urology1994，43，： | 1 |
| 16 | Kidney stone composition in overweight and obese patients:A preliminary report显示文摘 | Mosli HA Mosli HH Kamal WK | 2013 | Res Rep Urol2013，5，： | 1 |
| 17 | Compartmentation of caffeine and related purine alkaloids depends exclusively on the physical chemistry of their vacuolar complex formation with ehlorogenie acids显示文摘 | Mosli Waldhauser S S Baumann T W | 1996 | Phytochemistry1996，42，4： | 1 |
| 18 | Verticillium Wilt of olive in syria显示文摘 | Al-AHMAD M A MOSLI M N | 1993 | EPPO Bulletin1993，23，： | 1 |
| 19 | Compartmentation of caffeine and re- lated purine alkaloids depends exclusively on the physical chemistry of their vacuolar complex formation with chloro- geuic acids 显示文摘 | Mosli Waldhauser S S | 1996 | Phytochemistry1996，42，： | 1 |
| 20 | Retrospective analysis of disease association and outcome in histologically confirmed isehemic colitis显示文摘 | Mosli M Parfitt J Gregor J | 2013 | JDigDis2013，14，5： | 1 |
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