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2283篇 您的检索式：作者名="Morrison J"

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	题名	作者	年代	出处	被引量
1	Murine hepatocellular carcinoma derived stem cells reveal epithelial-to-mesenchymal plasticity显示文摘AIM To establish a model to enrich and characterize stemlike cells from murine normal liver and hepatocellular carcinoma(HCC) cell lines and to further investigate stem-like cell association with epithelial-to-mesenchymal transition(EMT).METHODS In this study,we utilized a stem cell conditioned serumfree medium to enrich stem-like cells from mouse HCC and normal liver cell lines,Hepa 1-6 and AML12,respectively.We isolated the 3-dimensional spheres and assessed their stemness characteristics by evaluating theRNA levels of stemness genes and a cell surface stem cell marker by quantitative reverse transcriptase-PCR(q RTPCR).Next,we examined the relationship between stem cells and EMT using q RT-PCR.RESULTS Three-dimensional spheres were enriched by culturing murine HCC and normal hepatocyte cell lines in stem cell conditioned serum-free medium supplemented with epidermal growth factor,basic fibroblast growth factor and heparin sulfate.The 3-dimensional spheres had enhanced stemness markers such as Klf4 and Bmi1 and hepatic cancer stem cell(CSC) marker Cd44 compared to parental cells grown as adherent cultures.We report that epithelial markers E-cadherin and ZO-1 were downregulated,while mesenchymal markers Vimentin and Fibronectin were upregulated in 3-dimensional spheres.The 3-dimensional spheres also exhibited changes in expression of Snai,Zeb and Twist family of EMT transcription factors.CONCLUSION Our novel method successfully enriched stem-like cells which possessed an EMT phenotype.The isolation and characterization of murine hepatic CSCs could establish a precise target for the development of more effective therapies for HCC.	Aparna Jayachandran Ritu Shrestha Bijay Dhungel I-Tao Huang Marianna Yumi Kawashima Vasconcelos Brian J Morrison Charmaine A Ramlogan-Steel Jason C Steel	2017	World Journal of Stem Cells2017，9，9：	4
2	Use of a novel Arg-Gly-Asp radioligand,18F-AH111585,to determine changes in tumor vascularity after antitumor therapy显示文摘	Morrison MS Ricketts SA Barnett J	2009	J Nucl Med2009，50，1：	1
3	Circadian rhythm of intraocular pressure in the rat显示文摘	MOORE C G JOHNSON E C MORRISON J C	1996	Curr Eye Res1996，15，：	1
4	Electromagnetic fields about a loop source of current显示文摘	Ryu J Morrison F H Ward S H	1970	Geophysics1970，35，：	1
5	显示文摘	Yee A Morrison S J Idriss H	2000	Catal Today2000，63，：	1
6	Respiratory muscle performance in normal elderly subjects and patients with COPD显示文摘	Morrison NJ Richardson J Dunn I	1989	Chest1989，95，：	1
7	Matrix metalloproteinases: What do they not do? New substrates and biological roles identified by murine models and proteomics显示文摘	Rodriguez D Morrison C J Overall CM	2010	Biochim Biophys Acta2010，1803，1：	1
8	Cloning of a delta opioid receptor by functional expression显示文摘	Evans C J Keith D E Morrison H	1992	Science1992，258，5090：	1
9	Airport infrastructure spillovers in a network system显示文摘	Cohen J P Morrison Paul C J	2003	Journal of Urban Economics2003，54，3：	1
10	Entrepreneurship and sustainable tourism:The houseboats of Kerala显示文摘	Kokkranikal J Morrison A	2002	Tourism and Hospitality Research2002，，4：	1
11	Life and death of neurons in the aging brain显示文摘	Morrison J H Hof P R	1997	Science1997，278，5337：	1
12	Evolution of the perioperative clinical nurse specialist role显示文摘	Morrison J D	2000	AORN J2000，72，2：	1
13	Effect of intrathecal magnesium in the presence or absence of local anaesthetic with and without lipophilic opioids : a systematic review and meta-a- nalysis显示文摘	Morrison A Hunter J Halpern S	2013	British Journal of Anaesthesia2013，3，12：	1
14	Relationship between pain and opioid analgesics on the development of delirium following hip fracture显示文摘	Morrison R S Magaziner J Gilbert M	2003	J Gerontol A Biol Sci Med Sci2003，58，1：	1
15	Relationship between pain and opioid analgesies on the development of delirium follow- ing hip fraeture显示文摘	Morrison RS Magaziner J Gilbert M	2003	J Gerontol A Biol Sei Med Sei2003，58，1：	1
16	Organizational silence : a barrier to change and development in a pluralistic world 显示文摘	MORRISON E W MILLIKEN F J	2000	Academy of Man- agement Review2000，25，4：	1
17	The Prediction andMeasurement of incompressible flow in a labyrinth seal 显示文摘	DEMKO J A MORRISON G L RHODE D L	1980	ASME Journal of Engineering Gas Turbines Power1980，111，4：	1
18	A study of ethanol reactions over Pt/CeO2 by temperature-trogrammed desorption and in situ FT-IR spectroscopy:Evidence of benzene formation显示文摘	YEE A MORRISON S J IDRISS H	2000	Journal of Catalysis2000，191，1：	1
19	Glycoprotein staining following eletrophoresis on acrylamide gels显示文摘	ZACHARIUS R M ZELL T E MORRISON J H	1969	Analytical Biochemistry1969，30，：	1
20	Physiological changes from 58 years of genetic improvement of short-season soybean cultivars in Canada显示文摘	Morrison M J Voldeng H D Cober E R	1999	Agronomy Journal1999，91，：	1

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