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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Comparative susceptibility of hospital isolates of Gram-negative bacteria to antiseptics and disinfectants 显示文摘 | Hommond SA Morgan JR Rusell AD | 1987 | J Hosp Infect1987，9，3： | 1 |
| 3 | Preventing the transmission of multidrug-resistant organisms:modeling the relative importance of hand hygiene and environmental cleaning interventions显示文摘 | Barnes SL Morgan DJ Harris AD | 2014 | Infect Control Hosp Epidemiol2014，35，9： | 1 |
| 4 | Bacterial resistance to antiseptics and disinfectants 显示文摘 | Russell AD Hammond SA Morgan JR | 1986 | J Hosp Infect1986，7，3： | 1 |
| 5 | Review of the benefits associated with fundamental movement skill competency in youth显示文摘 | Lubans DR Morgan PJ Cliff DP Barnett LM Okely AD | 2010 | Sports Med2010，，12： | 1 |
| 6 | Inflammatory lesions simulating malignancy显示文摘 | Morgan AD | 1964 | Br Jurol1964，，： | 1 |
| 7 | Breathing patterns during sleep in patients with nocturnal asthma显示文摘 | Morgan AD Rhind GB Connaughton JJ | | 0，，08： | 1 |
| 8 | Preventing the transmission of multidrug-resistant organisms:modeling the relative importance of hand hygiene and environmental cleaning interventions显示文摘 | Barnes SL Morgan DJ Harris AD | 2014 | Infect Control Hosp Epidemiol2014，35，9： | 1 |
| 9 | Endovagi?nal magnetic resonance imaging of stage 1 A/1B cervical cancer with A T2- and diffusion-weighted magnetic resonance tech?nique: Effect of lesion size and previous cone biopsy on tumor detectability显示文摘 | Charles-Edwards E Morgan V Attygalle AD | 2011 | Gynecol Oncol2011，120，3： | 1 |
| 10 | Human nasal car-tilage responds to oncostatin M in combination with interleu-kin 1 or tumour necrosis factor alpha by the release of collagenfragments via collagenases 显示文摘 | Morgan TG Rowan AD Dickinson SC | 2006 | Ann Rheum Dis2006，65，2： | 1 |
| 11 | Long-term results of cardiac transplantation in patients 65 years of age and older: a comparative analysis 显示文摘 | Morgan JA John R Weinberg AD | 2003 | Ann Thorac Surg2003，76，6： | 1 |
| 12 | Effect of agmatine on the escalation of intravenous cocaine and fentanyl self-administratian in rats 显示文摘 | Morgan AD Campbell UC Fans RD | 2002 | Pharmacol Biochem Behav2002，72，4： | 1 |
| 13 | Sex differences in physical dependence on orally self-administered phencyclidine(PCP) in rhesus monkeys(Macaca mulatta)显示文摘 | Perry JL Normile LM Morgan AD | 2006 | Exp Clin Psychopharmacol2006，14，1： | 1 |
| 14 | Highly precise and accurate Re-Os ages for molybdenite from tbe east Qinling molybdenum belt, Shaanxi Province, China 显示文摘 | Stein H J Markey R J Morgan J W Du AD Sun Y L | 1997 | Economic Geology1997，92，78： | 1 |
| 15 | Effects of baclofen on maintenance and reinstatement of intravenous cocaine self-administration in rats显示文摘 | Campbell UC Morgan AD Carroll ME | 1999 | Psychopharmacology(Berl)1999，143，2： | 1 |
| 16 | Prolonged donor ischemic time does not adversely affect long-term survival in adult patients undergoing cardiac transplantation显示文摘 | Morgan JA John R Weinberg AD | 2003 | J Thorac Cardiovasc Surg2003，126，5： | 1 |
| 17 | Sex differences in the effects of baclofen on the acquisition of intravenous cocaine self-administration in rats显示文摘 | Campbell UC Morgan AD Carroll ME | 2002 | Drug Alcohol Depend2002，66，1： | 1 |
| 18 | Treatment of acute hypoealeemia in critically ill multiple-trauma patients显示文摘 | Dickerson RN Morgan LG Cauthen AD | 2005 | JPEN J Parenter Enteral Nutr2005，29，6： | 1 |
| 19 | Breakpoints of the t( 11 ;18) ( q21 ; q21 ) in mucosa-associated lymphoid tissue (MALT) lymphoma lie within or near the previously undescribed gene MALT1 in chromosome 18显示文摘 | Morgan JA Yin Y Borowsky AD | 1999 | Cancer Res1999，59，24： | 1 |
| 20 | A clinicopatho- logic and immunohistochemical analysis of melanotic neuro- ectodermal tumor of infancy 显示文摘 | Barrett AW Morgan M Ramsay AD | 2002 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2002，93，6： | 1 |
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