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66篇 您的检索式:作者名="Morein"
    题名 作者 年代 出处 被引量
1Iscom佐剂增强含前S表位重组乙肝表面抗原的免疫原性显示文摘目的探讨Iscom佐剂对含前S表位重组乙肝表面抗原(SS1S2)免疫原性的影响。方法用纯化的SSIS2抗原与A1(OH),和Iscom佐剂分别配制疫苗,在0d和14d时采用肌肉和皮下注射方式免疫BALB/c小鼠,免后14d各取-半小鼠采血,测定乙肝病毒s、前s1和前s2抗体滴度以及总的IgG1和IgG2a抗体滴度,并计算IgG2a和IgG1抗体比例。同时分离脾淋巴细胞,进行IFN-1酶联斑点(ELISPOT)测定。结果单针免疫时,两组疫苗血清样品乙肝病毒S、前S1和前S2抗体阳转率、抗体滴度及IFN-1分泌细胞数相当,但Iscom佐剂疫苗组IgG2a抗体比例较高;加强免疫后,两组疫苗抗体滴度均呈上升趋势,Iscom疫苗组抗体滴度上升幅度大于AI(OH),疫苗组,两者S、前S1和前s2抗体滴度差异均有统计学意义。加强免疫后Iscom疫苗组IgG2a抗体比例保持平衡,而A1(OH),疫苗组IgG2a抗体比例进-步降低。在细胞免疫方面,Iscom疫苗组在加强免疫后产生的特异性IFN-γ分泌细胞数显著超过AI(OH),疫苗组。结论本研究初步显示,Iscom佐剂对含前S表位重组乙肝表面抗原具有比Al(OH),佐剂更强地免疫增强作用。谭昌耀 叶琳 蒋丽明 张鹏艳 胡波 Bror Morein 2011中华微生物学和免疫学杂志2011,31,7:2
2Iscom, a novel structure for antigenic presentation of membrane proteins from enveloped viruses显示文摘 Sundquist B Hoglund S 1984Nature (London)1984,308,:1
3lmmunostimulating complexes ( ISCOMs ) for nasal vaccination 显示文摘Hu KF Lovgren-Bengtsson K Morein B 2001Adv Drug Deliv Rev2001,51,13:1
4ISCOMs, a novel structure for antigenic presentation of membrane proteins from enveloped viruses显示文摘Morein B Sundquist B Hoglumd S 1984Nature1984,308,:1
5Influence of maternal immunity on antibody and T-cell response in mice显示文摘Blomqvist G A L(o)vgren-Bengtsson K Morein 8 0,,17:1
6Immunomodulation by Iscoms Immune Stimulating Complexes显示文摘Morein B Bengtsson K L 1999Methods1999,19,1:1
7Functional aspects of ISCOMs显示文摘Morein F Bengtsson K L 1998Immunol Cell BioI1998,76,4:1
8Current status and potential application of ISCOMs in veterinary medicine显示文摘Morein B Hu K F Abusugra I 2004Adv Drug Deliv Rev2004,56,10:1
9ISCOM,a novel structure for antigenic presentation of membrane proteins from enveloped viruses显示文摘Morein B Sundquist B Hoglund S 1984Nature1984,308,:1
10Increased immunogenicity of a non-amphipathic protein(BSA) after inclusion into iscoms显示文摘MOREIN B EKSTRIM J LOVGREN K 1990J Immu Met1990,128,:1
11Iscom, a novel struc- ture for antigenic presentation of membrane proteins from enve- loped viruses 显示文摘Morein B Sundquist B Hoglund S 1984Nature1984,308,5958:1
12Increased immunogenicity of a non-amphipathic protein (BSA) after inclusion into ISCOMs显示文摘Morein B EkstromJ Lovgrem K 1990J Immunol Methods1990,128,2:1
13Current status and potential aplica- tion of ISCOMs in veterinary medicine 显示文摘Morein B Hu KF Abusugra I 2004Adv Drug Deliv Rev2004,56,10:1
14WebSOS:An overlay-based system for protecting Web servers from denial of service attacks显示文摘Stavrou A Cook D Morein W 2005The International Journal of Computer and Telecommunications Networking2005,48,:1
15Forest Fires:An Exampie of Self-Organized Critical Behavior 显示文摘Malamud B Morein G Turcotte D 1998Science1998,281,:1
16Increased immunogenicity of a non-amphipathic protein (BSA) after inclusion into iscoms 显示文摘MOREIN B EKSTRIJM J LC)VGREN K 1990Journal of Immunological Methods1990,128,2:1
17Immunostimulating com- plexes (ISCOMs) for nasal vaccination 显示文摘Hu KF LSvgren-Bengtsson K Morein B 2001Adv Drug Deliv Rev2001,51,13:1
18Iscom, a delivery system for parenteral and mucosal vacci- nation 显示文摘Morein B Villacres-Eriksson M Lovgren-Bentsson K 1998DevBiol Stand1998,92,:1
19Shift from Brand to Product Line Marketing显示文摘Morein J 1975Harvard Business Review1975,53,910:1
20Iscom,a novel structure for antigenic presentation of membrane proteins from enveloped viruses显示文摘 Sundquist B Hoglund S 1984Nature1984,308,5958:1
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