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| 1 | Treatment of hepatitis C virus genotype 4 with peginterferon alfa-2a: Impact of bilharziasis and fibrosis stage显示文摘AIM: To evaluate pegylated interferon alpha2a (PegIFN- α2a) in Egyptian patients with HCV genotype 4, and the impact of pretreatment viral load, co-existent bilharziasis and histological liver changes on response rate. METHODS: A total of 73 na?ve patients (61 with history of bilharziasis) with compensated chronic HCV genotype 4 were enrolled into: group A (38 patients) who received 180 mg PegIFN-alpha2a subcutaneously once weekly for a year and group B (35 patients) received IFN alpha-2a 3 MU 3 times weekly. Ribavirin was added to each regimen at a dose of 1200 mg. Patients were followed for 72 wk and sustained response was assessed. RESULTS: Significant improvement in both end of treatment response (ETR) (P < 0.002) and sustained response (SR) (P < 0.05) was noted with pegylated interferon, where ETR was achieved in 29 (76.3%) and 14 patients (40%) in both groups respectively, and 25 patients in group A (65.8%) and 9 (25.7%) in group B could retain negative viraemia by the end of follow up period. Sustained virological response (SVR) showed a significant negative correlation with age and positive correlation with pretreatment inflammation in patients receiving PegIFN. Viral clearance after 3 mo of therapy was associated with high incidence of ETR and SR (P < 0.001), but without significant difference between both forms of interferon. Significant improvement in response was achieved in patients with high grade fibrosis (grade 3 and 4) with PegIFN-α2a, where SR was seen in 5 out of 13 patients in group A, but none in group B. There was no significant difference in response betweenbilharzial and non-bilharzial patients in both groups. In terms of safety and tolerability, neutropenia was the predominant side effect; both drugs were comparable. CONCLUSION: PegIFN-α2a combined with ribavirin results in improvement in sustained response in HCV genotype 4, irrespective of history of bilharzial infestation. | MF Derbala SR Al Kaabi NZ El Dweik F Pasic MT Butt R Yakoob A Al-Marri AM Amer N Morad A Bener | 2006 | World Journal of Gastroenterology2006，12，35： | 3 |
| 2 | The effect of communication and synchronization on Amdahl's law in multicore systems显示文摘 | YAVITS L MORAD A and GINOSAR R | 2014 | Parallel Computing2014，40，1： | 1 |
| 3 | Distribution of diagenetic alterations in fluvial, deltaic, and shallow marine sandstones within a sequence stratigraphic framework:Evidence from the Mullaghmore Formation ( Carboniferous), NW Ireland 显示文摘 | Ketzer J M Morad S Evans R et a/ | 2002 | Journal of Sedimentary Research2002，72，6： | 1 |
| 4 | The impact of diagenesis on the heterogeneity of sandstone reservoirs: A review of the role of depositional facies and sequence stratigraphy显示文摘 | Morad S Khalid A R Ketzer J M | 2010 | AAPG Bulletin2010，94，8： | 1 |
| 5 | A uniform enzymatic method for dissociation of myocytes from hearts and stomachs of vertebrates显示文摘 | Mitra R Morad M | 1985 | Am J Physiol Heart Circ Physiol1985，249，： | 1 |
| 6 | Diagenesis and reservoir quality evolution of palaeocene deep-water,marine sandstones,the Shetland-Faroes Basin,British continental shelf显示文摘 | Mansurbeg H Morad S Salem A Marfil R El-ghali M A K Nystuen J P Caja M A Amorosi A Garcia D A Iglesia La | 2008 | Marine and Petroleum Geology2008，25，： | 1 |
| 7 | 显示文摘 | Nasser HZ | 2000 | Toxicol Appl Pharm2000，166，1： | 1 |
| 8 | Distribution of diage- netic alterations in fluvial, deltaic, and shallow marine sand- stones within a sequence stratigraphic framework: Evidence from the Mullaghmore Formation(Carboniferous), NW Ireland 显示文摘 | Ketzer J M Morad S Evans R | 2002 | Journal of Sedimentary Research2002，72，6： | 1 |
| 9 | Albitization of detrital plagioclase in Triassic reservoir sandstones from the Snorre Field, Norwegian North Sea显示文摘 | Morad S Bergan M Knard R | 1990 | Journal of Sedimentary Petrology1990，60，3： | 1 |
| 10 | Clay minerals in sandstones : Control on formation,distribution and evolution 显示文摘 | Worden R H Morad S | 2003 | International Association of Sedimentologists Special Publication2003，，34： | 1 |
| 11 | Clay Minerals in Sandstones: Controls on Formation, Distribution and Evolution 显示文摘 | Worden R H Morad S | 2003 | Special Publication of the International Association of Sedimentologists2003，34，： | 1 |
| 12 | Utilization of a synthetic peptide as a tool to study the interaction of heavy metals with the zinc finger domain of proteins critical for gene expression in the developing brain显示文摘 | Morad R Nasser HZ | 2000 | Toxico Appl Pharm2000，166，： | 1 |
| 13 | TRPC channels determine hu- man keratinocyte differentiation : new insight into basal cellcarcinoma 显示文摘 | Benjamin B Vlehen K Morad R | 2008 | Cell Calcium2008，43，5： | 1 |
| 14 | Distribution of diagenetic alterations in fluvial,deltaic,and shallow marine sandatones within a sequence stratigraphic framework:evidence from the Mullaghmore Formation (Carboniferous),NW Ireland显示文摘 | Ketzer J M Morad S Evans R | 2002 | Journal of Sedimentary Research2002，72，： | 1 |
| 15 | Nitric oxide and interlukin- 6 levels in intellectual disability adults with epilepsy显示文摘 | Carmeli E Beiker R Morad M | 2009 | Res Dev Disabil2009，30，： | 1 |
| 16 | A uniform enzymatic method for dissociation of myocytes from hearts and stomachs of vertebrates 显示文摘 | Morad M | 1985 | Am J Physiol1985，249，52： | 1 |
| 17 | Two types of calcium channels in guinea pig ventricular myocytes显示文摘 | MITRAA R MORAD M | 1986 | Progc Natl Acad Sci USA1986，83，： | 1 |
| 18 | Nitric oxide and interlukin-6 lev-els in intellectual disability adults with epilepsy显示文摘 | Carmeli E Beiker R Morad M | 2009 | Res Dev Dis-abil2009，30，3： | 1 |
| 19 | Dolomite diagenesis and porosity preservation in lithic reservoirs: Carm-polis member, Sergipe-Alagoas basin, northeastern Brazil显示文摘 | Souza R S de Ros L F Morad S | 1995 | AAPG Bulletin1995，79，： | 1 |
| 20 | Clay minerals in sandstones: Clay ce- ments in sandstones: Controls on formation,distribution and evolution 显示文摘 | Worden R Morad S | 2003 | International Association of Sedimentologists Special Publication2003，34，： | 1 |
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