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| 1 | Use of a combination strategy to improve neuroprotection and neuroregeneration in a rat model of acute spinal cord injury显示文摘Spinal cord injury is a very common pathological event that has devastating functional consequences in patients. In recent years, several research groups are trying to find an effective therapy that could be applied in clinical practice. In this study, we analyzed the combination of different strategies as a potential therapy for spinal cord injury. Immunization with neural derived peptides(INDP), inhibition of glial scar formation(dipyridyl: DPY), as well as the use of biocompatible matrix(fibrin glue: FG) impregnated with bone marrow mesenchymal stem cells(MSCs) were combined and then its beneficial effects were evaluated in the induction of neuroprotection and neuroregeneration after acute SCI. Sprague-Dawley female rats were subjected to a moderate spinal cord injury and then randomly allocated into five groups: 1) phosphate buffered saline; 2) DPY; 3) INDP + DPY; 4) DPY+ FG; 5) INDP + DPY + FG + MSCs. In all rats, intervention was performed 72 hours after spinal cord injury. Locomotor and sensibility recovery was assessed in all rats. At 60 days after treatment, histological examinations of the spinal cord(hematoxylin-eosin and Bielschowsky staining) were performed. Our results showed that the combination therapy(DPY+ INDP + FG+ MSCs) was the best strategy to promote motor and sensibility recovery. In addition, significant increases in tissue preservation and axonal density were observed in the combination therapy group. Findings from this study suggest that the combination theapy(DPY+ INDP + FG + MSCs) exhibits potential effects on the protection and regeneration of neural tissue after acute spinal cord injury. All procedures were approved by the Animal Bioethics and Welfare Committee(approval No. 178544; CSNBTBIBAJ 090812960)on August 15, 2016. | Elisa García Roxana Rodríguez-Barrera Vinnitsa Buzoianu-Anguiano Adrian Flores-Romero Emanuel Malagón-Axotla Marco Guerrero-Godinez Estefanía De la Cruz-Castillo Laura Castillo-Carvajal Monserrat Rivas-Gonzalez Paola Santiago-Tovar Ivis Morales Cesar Borlongan Antonio Ibarra | 2019 | Neural Regeneration Research2019，14，6： | 6 |
| 2 | Comparative effects of captopril and L-carnitine on blood pressure and antioxidant enzyme gene expression in the heart of spontaneously hypertensive rats 显示文摘 | Migue C M Monserrat A M | 2010 | European J Pharm aeol2010，632，： | 1 |
| 3 | Validation and comparison of advanced differential interferometry techniques: murcia metropolitan area case study显示文摘 | HERRERA G TOMAS R LOPEZ-SANCHEZ J M DELGADO J VICENTE F MULAS J COOKSLEY G SANCHEZ M DURO J ARNAUD A BLANCO P DUQUE S MALLORQUI J J DE la VEGA-PANIZO R MONSERRAT O | 2008 | ISPRS Journal of Photogrammetry and Remote Sensing2008，，： | 1 |
| 4 | Microcystin-induced oxidative stress in Laeonereis acuta (Polychaeta,Nereididae)显示文摘 | Leo J C Geracitano L A Monserrat J M | 2008 | Marine Environmental Research2008，66，： | 1 |
| 5 | Comparative effects of captopril and L-carnitine on blood pressure and antioxidant enzyme gene expression in the heart of spontaneously hypertensive rats显示文摘 | MIGUEL-CARRASCO J L MARíA T Monserrat A M | 2010 | European Journal of Pharmacology2010，632，： | 1 |
| 6 | Factors related to the preference for conscious sedation in upper gastrointestinal endoscopies显示文摘 | Campo R Brullet F Monserrat A | 1998 | Gastraenteralagy1998，110，4： | 1 |
| 7 | The role of inflammatory markers in the cardioprotective effect of L-carnitine in L-NAME-induced hypertension 显示文摘 | Miguel-Carrasco JL Mate A Monserrat MT | 2008 | Am J Hypertens2008，21，： | 1 |
| 8 | Physiologi- cal and Antioxidant Enzyme Responses to Acute and Chronic Ex- posure of Laeonereis acuta (Polychaeta Nereidiae) to Copper显示文摘 | GERACITANO L MONSERRAT J M BIANCH1NI A | 2002 | Journal of Experimental Marine Biology and Ecology2002，277，2： | 1 |
| 9 | Physiological and antioxidant enzyme responses to acute and chronic exposure of Laeonereis acuta (Polychaeta N ereidiae) to copper显示文摘 | Geracitano L Monserrat JM Bianchini A | 2002 | Exp Marine Biol Ecol2002，277，： | 1 |
| 10 | Pollution biomarkers in estuarine animals: Critical review and new perspectives显示文摘 | Monserrat J M Martinez P E Geracitano L A | 2007 | Comp Biochem Physiol C Toxicol Pharmacol2007，146，12： | 1 |
| 11 | Physiological and antioxidant enzyme responses to acute and chronic exposure of Laeonereis acuta (Polychaeta, Nereididae) to copper 显示文摘 | GERACITANO L MONSERRAT J M BIANCHINI A | 2002 | Journal of Experimental Marine Biology and Ecology2002，277，2： | 1 |
| 12 | Microcystin-induced oxidativestress in Laeonereis aeuta (Polychaeta, Nereididae)显示文摘 | Leo J C C-eracitano L A Monserrat J M | 2008 | Marine Environmental Re- search2008，66，： | 1 |
| 13 | Fa- milial dilated cardiomyopathy and isolated left ventricular non- compaction associated with lamin A/C gene mutations 显示文摘 | Hermida-Prieto M Monserrat L Castro-Beiras A | 2004 | Am J Cardiol2004，94，1： | 1 |
| 14 | IMT-Advanced and Nextgeneration Mobile Networks显示文摘 | Mohr W Monserrat J F Osseiran A | 2011 | IEEE Communication Magazine2011，49，2： | 1 |
| 15 | Micronuclei induced by airborne particulate matter from Mexico City显示文摘 | Deborah A. Roubicek M. Eugenia Gutiérrez-Castillo Monserrat Sordo Mariano E. Cebrián-García Patricia Ostrosky-Wegman | 2007 | -Genetic Toxicology and Environmental Mutagenesis2007，，1： | 1 |
| 16 | Ammonia exposure of Chasmagnathus granulata (Crustacea,Decapoda) Dana,1851:accumulation in haemolymph and effects on osmoregulation显示文摘 | Rebelo M F Santos E A Monserrat J M | 1999 | Comp Biochem Physiol A1999，122，： | 1 |
| 17 | Comparative effects of captopril andL-carnitine on blood pressure and antioxidant enzyme gene expression in the heart of spontaneously hypertensive rats显示文摘 | Miguel-Carrasco J L Monserrat M T Mate A | | 0，，1： | 1 |
| 18 | Ammonia exposure of Chasmagnathus granulata ( Chastaeea, Decapoda) Dana, 1851 : accumulation in haemolymph and effects oil osmoregulatiou 显示文摘 | REBELO M F SANTOS E A MONSERRAT J M | 1999 | Comp Biochem Physiol A1999，122，： | 1 |
| 19 | Familial dilated cardiomyopathy and isolated left ventricular noncompaction associated with lamin A/C gene mutations 显示文摘 | HERMIDA-PRIETO M MONSERRAT L CASTRO-BEIRAS A | 2004 | Am J Cardiol2004，94，1： | 1 |
| 20 | Ammonia ex- posure of Chasmagnathus granulates (Crustacea, Deca- pada) Danna, 1851: accumulation in haemolymph and effects on osmoregulafion显示文摘 | Rebelo M F Santos E A Monserrat J M | 1999 | Comparative Biochemistry and Physiology1999，122，： | 1 |
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