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| 1 | 在有类型 1 自体免疫的肝炎的日本病人的尖锐表示的 Centrilobular 坏死显示文摘 AIM:To compare clinicopathological features of acute presentation of type 1 autoimmune hepatitis(AIH) with or without centrilobular necrosis(CN).METHODS:Our study comprised 41 patients with biopsy-proven acute presentation(acute exacerbation phase 36,acute hepatitis phase 5) of type 1 AIH at our hospital from 1975 to 2009.Elevated serum alanine aminotransferase(ALT)(> 5x upper limit of normal) identified acute presentation of the disease.We compared clinicopathological features of these AIH patients with or without CN.The data used for analysis included patient background(age,sex,type of disease,presence of complications with other autoimmune diseases,human leukocyte antigen,and International Autoimmune Hepatitis Group score),clinical parameters at presentation(ALT,alkaline phosphatase,IgG,anti-nuclear antibodies,and anti-smooth muscle antibodies),histology and therapy.RESULTS:CN was found in 13(31.7%) patients with acute presentation(acute exacerbation phase 10,acute hepatitis phase 3) of AIH.Serum IgG levels of patients with CN were significantly lower than those of patients without CN(mean:2307 mg/dL vs 3126 mg/dL,P < 0.05),while antinuclear antibody-negative rates were significantly higher(30.7%vs 3.5%,P < 0.05).However,other clinical features were similar between the two groups.The frequency of advanced fibrosis in patients with CN was significantly lower than in patients without CN(F0-2:84.6% vs 35.7%,F3-4:15.4% vs 64.3%,P < 0.05).Other histological features were similar between the two groups.Although there was no significant difference between groups when evaluated using the revised original score(12 vs 14),the simplified AIH score of patients with CN was significantly lower(6 vs 7,P < 0.05).Frequency of DR4 was similar between patients with and without CN.CONCLUSION:CN is observed in both Japanese patients with acute hepatitis phase and acute exacerbation phase of type 1 AIH,although AIH with CN often shows clinical features of the genuine acute form. | Kazumichi Abe Yukiko Kanno Ken Okai Fumiko Katsushima Kyoko Monoe Hironobu Saito Atsushi Takahashi Junko Yokokawa Hiromasa Ohira | 2012 | World Journal of Hepatology2012，4，9： | 5 |
| 2 | Teaching clinical cardiovascular physiology at the semmelweis university显示文摘The purpose of this one-semester elective course is:to refresh and extend in selected topics-the basic knowledge related to normal and pathological functions of the human circulatory system; to integrate the latest scientific results related to different levels of the cardiovascular system from molecular level to system physiology; to discuss and demonstrate measurement principles and techniques,as well as | Emil Monos Tamás Ivanics Márk Kollai | 2009 | 中国病理生理杂志2009，25，11： | 2 |
| 3 | Plaque characteris- tics of asymptomatic carotid stenosis and risk of stroke 显示文摘 | Mono ML Karameshev A Slotboom J | 2012 | Cere- brovasc Dis2012，34，56： | 1 |
| 4 | Stimulation of T cell via CD44 requires leukocytes-fumction-associeted antigen interaction and IL-2 production显示文摘 | Funaro A Spagnoli GC Mono M | 1994 | Hum Immunol1994，40，4： | 1 |
| 5 | Restenosis after microsurgical non-patch carotid endarterectomy in 586 patients显示文摘 | Reinert M Mono ML Kuhlen D | | 0，，： | 1 |
| 6 | Long-Term Propensity Score–Matched Comparison of Percutaneous Closure of Patent Foramen Ovale With Medical Treatment After Paradoxical Embolism显示文摘 | Andreas Wahl Peter Jüni Marie-Luise Mono Bindu Kalesan Fabien Praz Laura Geister Lorenz R?ber Krassen Nedeltchev Heinrich P. Mattle Stephan Windecker Bernhard Meier | 2012 | Circulation2012，，6： | 1 |
| 7 | Associa- tion of variants of the intedeukin-23 receptor gene with susceptibility to pediatric Crohn's disease 显示文摘 | Baldassano RN Bradfi eld JP Monos DS | 2007 | Clin Gastro- enterol Hepatol2007，5，： | 1 |
| 8 | Long-term propensity seore- matched Comparison of percutaneous closure of Patent foramen oval with medical treatment after paradoxical embolism 显示文摘 | Wahl A Juni P Mono ML | 2012 | Circulation2012，125，6： | 1 |
| 9 | Rhabdomyosarco- ma:invading the orbit in an adult显示文摘 | Friling R Marcus M Monos T | 1994 | Ophthal Plast Re- constr Surg1994，10，4： | 1 |
| 10 | Long-term propensity score-matched comparison of percutaneous closure of patent foramen ovale with medical treatment after paradoxical embolism显示文摘 | Wahl A Jüni P Mono ML | 2012 | Circulation2012，125，6： | 1 |
| 11 | Ethanol - induced apoptosis inhuman liver adenocarcinoma cells ( SK - Hepl ) : Fas - and mito-chondria -mediated pathways and interaction with MAPK signa-ling system显示文摘 | Mono Y Tsuji M Inagaki M | 2013 | Toxicol In Vitro2013，6，： | 1 |
| 12 | Ophthalmic mani-festations in Langerhans cell histiocytosis显示文摘 | Levy J Monos T Kapelushnik J | | 0，，： | 1 |
| 13 | Deregulated expression of the per2 gene in human colorectal carcinoma显示文摘 | Michal Zeman Marián Vician Jana Monosíková Richard Reis Iveta Herichová | 2008 | Molecular Medicine Reports2008，，4： | 1 |
| 14 | Retinopathy of prematurity in multiple-gestation,very low birth weight infants显示文摘 | Friling R Rosen SD Monos T | 1997 | J Pediatr Ophthalmol Strabismus1997，34，2： | 1 |
| 15 | Semiconductor quantum dot/albumin complex is a long life and highly photostable endosome marker显示文摘 | Hanaki K Mono A Oku T | 2003 | Biochem Biophys Res Commun2003，302，3： | 1 |
| 16 | Three-month and long-term outcomes and their predictors in acute basilar artery occlusion treated with intra-arterial thrombolysis显示文摘 | Jung S Mono ML Fischer U | | 0，，07： | 1 |
| 17 | Long-term propensity score- matched Comparison of percutaneous closure of Patent foramen oval with medical treatment after paradoxical embolism 显示文摘 | Wahl A Juni P Mono ML | 2012 | Circulation2012，125，6： | 1 |
| 18 | Plaque characteristics of asymptomatic carotid stenosis and risk of stroke显示文摘 | Mono ML Karameshev A Slotboom J | 2012 | Cerebrovasc Dis2012，34，： | 1 |
| 19 | Effects of multigrooved surf aces on osteoblast-ike cells in vitro: Scan-ning electron microscopic observation and mRNA expression of osteopontin and os- teocalcin显示文摘 | MATSUZAKA K YOSHINARI M SHI- MONO M | 2004 | Journal of Biomedical Ma- terials Research Part A2004，68，2： | 1 |
| 20 | Endovascular therapy in 201 patients with acute symptomatic occlusion of the internal carotid artery显示文摘 | Fischer U Mono ML Schroth G | 2013 | Eur J Neurol2013，20，7： | 1 |
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