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| 1 | Is early limited surgery associated with a more benign disease course in Crohn's disease?显示文摘AIM:To analyze the difference in disease course and need for surgery in patients with Crohn’s disease(CD).METHODS:Data of 506 patients with incident CD were analyzed(age at diagnosis:31.5±13.8 years).Both hospital and outpatient records were collected prospectively with a complete clinical follow-up and comprehensively reviewed in the population-based Veszprem province database,which includes incident CD patients diagnosed between January 1,1977 and December 31,2008.Follow-up data were collected until December 31,2009.All patients included had at least 1year of follow-up available.Patients with indeterminate colitis at diagnosis were excluded from the analysis.RESULTS:Overall,73 patients(14.4%)required resective surgery within 1 year of diagnosis.Steroid exposure and need for biological therapy were lower in patients with early limited surgery(P<0.001 and P=0.09).In addition,surgery rates during follow-up in patients with and without early surgery differed significantly after matching on propensity scores(P<0.001,HR=0.23).The need for reoperation was also lower in patients with early limited resective surgery(P=0.038,HR=0.42)in a Kaplan-Meier and multivariate Cox regression(P=0.04)analysis.However,this advantage was not observed after matching on propensity scores(PLogrank=0.656,PBreslow=0.498).CONCLUSION:Long-term surgery rates and overall exposure to steroids and biological agents were lower in patients with early limited resective surgery,but reoperation rates did not differ. | Petra Anna Golovics Laszlo Lakatos Attila Nagy Tunde Pandur Istvan Szita Mihaly Balogh Csaba Molnar Erzsebet Komaromi Barbara Dorottya Lovasz Michael Mandel Gabor Veres Lajos S Kiss Zsuzsanna Vegh Peter Laszlo Lakatos | 2013 | World Journal of Gastroenterology2013，19，43： | 3 |
| 2 | NKX2-3 and IRGM variants are associated with diseasesu sceptibility to IBD in Eastern European patients显示文摘AIM: To investigate variants of immunity-related GT-Pase family M (IRGM) and NKX2-3 genes and genotype-phenotype in Eastern European patients with inflammatory bowel disease (IBD).METHODS: We analyzed 1707 Hungarian and Czech subjects with Crohn’s disease (CD) (n = 810, age: 37.1 ± 12.6 years, duration: 10.7 ± 8.4 years) and ulcerative colitis (UC) (n = 428, age: 43.7 ± 15.0 years, duration: 12.6 ± 9.9 years), as well as 469 healthy controls. IRGM rs13361189, NKX2-3 rs10883365 and ECM1 rs13294 polymorphisms were tested by LightCy-cler allele discrimination. Detailed clinical phenotypes were determined by reviewing the medical charts. RESULTS: NKX2-3 rs10883365 variant allele was as-sociated with increased risk for CD (P = 0.009, OR = 1.24, 95% CI = 1.06-1.48) and UC (P = 0.001, OR = 1.36, 95% CI = 1.13-1.63), whereas variant IRGM allele increased risk for CD (P = 0.029, OR = 1.36, 95% CI = 1.03-1.79). In contrast, ECM1 rs13294 was not associat-ed with either CD or UC. In CD, the variant IRGM allele was associated with a colon-only location (P = 0.02, OR = 1.62, 95% CI = 1.07-2.44), whereas in UC, the ECM1 variant was associated with cutaneous manifestations (P = 0.002, OR = 3.36, 95% CI = 1.48-7.63). Variant alleles did not predict resistance to steroids or azathio-prine, efficacy of infliximab, or need for surgery. CONCLUSION: NKX2-3 and IRGM are susceptibility locifor IBD in Eastern European patients. Further studies are needed to confirm the reported phenotype-genotype associations. | Nora Meggyesi Lajos S Kiss Magdalena Koszarska Martin Bortlik Dana Duricova Laszlo Lakatos Tamas Molnar Martin Lenicek Libor Vítek Istvan Altorjay Maria Papp Zsolt Tulassay Pal Miheller Janos Papp Attila Tordai Hajnalka Andrikovics Milan Lukas Peter Laszlo Lakatos | 2010 | World Journal of Gastroenterology2010，16，41： | 2 |
| 3 | Vincamine and vincanol are potent blockers of voltage-gated Na- channels 显示文摘 | Erdo S L Molnar P Lakics V | 1996 | EurJPharmacol1996，314，： | 1 |
| 4 | Separation and determination of ergotoxine and dihydroergotoxine alkaloids by a TLC method显示文摘 | SZEPESI G MOLNAR J NYIREDY S | 1979 | Fresenius J Anal Chem1979，294，： | 1 |
| 5 | Methodology for Thermal Evaluation of Multichip Modules 显示文摘 | Lall Balwant S Guenin Bruce M Molnar Ronald J | 1995 | IEEE Trans Comp Packg Manufa Technol Part A1995，18，4： | 1 |
| 6 | Protein microchips in biomedicine and biomarker discovery显示文摘 | Spisak S Tulassay Z Molnar B | 2007 | Electrophoresis2007，28，23： | 1 |
| 7 | Geological and geophysical evidence for deep subduction of continental crust beneath the Pamir显示文摘 | BURTMAN V S MOLNAR P | 1993 | Geol Soc Am1993，281，： | 1 |
| 8 | Brief therapy: focused solution development显示文摘 | De Shazer S Berg IK Lipchik E Nunnally E Molnar A Gingerich W | 1986 | Fam Process1986，25，2： | 1 |
| 9 | Distribution of a Secale cereal DNA repeat sequence among 25 Hordeum species显示文摘 | Gupta P K Fedeak G Molnar S J | 1989 | Genome1989，32，： | 1 |
| 10 | Validation of the Kidney Disease Quality of Life-Short Form questionnaire in kidney transplant patients显示文摘 | Barotfi S Molnar MZ Almasi C | 2006 | J Psychosom Res2006，60，5： | 1 |
| 11 | New materials for semiconductor spinelectronics显示文摘 | Von Molnar S Read D | 2003 | Proceedings of the IEEE2003，91，： | 1 |
| 12 | Human tooth wear,tooth function and cultural variability显示文摘 | Molnar S | 1971 | American Journal of Physical Anthropology1971，34，2： | 1 |
| 13 | Anti -inflammatory effects of excessive weight loss: potent suppression of adipose interleukin 6 and tumour necrosis factor a expres-sion显示文摘 | MOSCHEN AR MOLNAR C GEIGER S | 2010 | Gut2010，59，9： | 1 |
| 14 | Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression 显示文摘 | Choudary PV Molnar M Evans S J | 2005 | Proc Natl Acad Sci U S A2005，102，15： | 1 |
| 15 | Tooth wear and culture:A survey of tooth functions among some prehistoric populations显示文摘 | Molnar S Barrett MJ Brian L | 1972 | Current Anthropology1972，13，5： | 1 |
| 16 | Diluted magnetic Ⅲ- Ⅴ semiconductors 显示文摘 | MUNEKATA H OHNO H von MOLNAR S | 1989 | Phys Rev Lett1989，63，： | 1 |
| 17 | Impact of subclinical thyroid disorders on coronary heart disease,cardiovascular and all-cause mortality:a meta-analysis显示文摘 | SINGH S DUGGAL J MOLNAR J | 2008 | Int J Cardiol2008，125，1： | 1 |
| 18 | Isolation of equine herpesvirus type 2from foals,showing respiratory symptoms显示文摘 | Palfi V Belak S Molnar T | 1978 | Zentralbl Veterinarmed B1978，25，2： | 1 |
| 19 | A person - centered approach to subjective well - being 显示文摘 | Busseri M A Sadava S W Molnar D S DeCourville N | 2009 | Journal of Happiness Studies2009，，1： | 1 |
| 20 | Procoagulant factors in patients with cancer显示文摘 | Molnar S Guglielmone H Lavarda M | 2007 | Hematology2007，12，6： | 1 |
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