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| 1 | Dynamic stability of axially accelerating viscoelastic plates with longitudinally varying tensions显示文摘The dynamic stability of axially accelerating plates is investigated.Longitudinally varying tensions due to the acceleration and nonhomogeneous boundary conditions are highlighted.A model of the plate combined with viscoelasticity is applied.In the viscoelastic constitutive relationship,the material derivative is used to take the place of the partial time derivative.Analytical and numerical methods are used to investigate summation and principal parametric resonances,respectively.By use of linear models for the transverse behavior in the small displacement regime,the plate is confined by a viscous damping force.The generalized Hamilton principle is used to derive the governing equations,the initial conditions,and the boundary conditions of the coupled planar vibration.The solvability conditions are established by directly using the method of multiple scales.The Routh-Hurwitz criterion is used to obtain the necessary and sufficient condition of the stability.Numerical examples are given to show the effects of related parameters on the stability boundaries.The validity of longitudinally varying tensions and nonhomogeneous boundary conditions is highlighted by comparing the results of the method of multiple scales with those of a differential quadrature scheme. | Youqi TANG Dengbo ZHANG Mohan RUI Xin WANG Dicheng ZHU | 2016 | Applied Mathematics and Mechanics(English Edition)2016，37，12： | 1 |
| 2 | Oncolytic adenoviruses expressing checkpoint inhibitors for cancer therapy显示文摘Despite the remarkable success of immune checkpoint inhibitors(ICIs),primary resistance to ICIs causes only subsets of patients to achieve durable responses due to the complex tumor microenvironment(TME).Oncolytic viruses(OVs)can overcome the immunosuppressive TME and promote systemic antitumor immunity in hosts.Engineered OVs armed with ICIs would likely have improved effectiveness as a cancer therapy.According to the diverse immune cell landscapes among different types of tumors,we rationally and precisely generated three recombinant oncolytic adenoviruses(OAds):OAd-SIRPα-Fc,OAd-Siglec10-Fc and OAd-TIGIT-Fc.These viruses were designed to locally deliver SIRPα-Fc,Siglec10-Fc or TIGIT-Fc fusion proteins recognizing CD47,CD24 or CD155,respectively,in the TME to achieve enhanced antitumor effects.Our results suggested that OAd-SIRPα-Fc and OAd-Siglec10-Fc both showed outstanding efficacy in tumor suppression of macrophage-dominated tumors,while OAd-TIGIT-Fc showed the best antitumor immunity in CD8+T-cell-dominated tumors.Importantly,the recombinant OAds activated an inflammatory immune response and generated long-term antitumor memory.In addition,the combination of OAd-Siglec10-Fc with anti-PD-1 significantly enhanced the antitumor effect in a 4T1 tumor model by remodeling the TME.In summary,rationally designed OAds expressing ICIs tailored to the immune cell landscape in the TME can precisely achieve tumor-specific immunotherapy of cancer. | Daoyuan Xie Yaomei Tian Die Hu Yuanda Wang Yuling Yang Bailing Zhou Rui Zhang Zhixiang Ren Mohan Liu Jie Xu Chunyan Dong Binyan Zhao Li Yang | 2023 | Signal Transduction and Targeted Therapy2023，8，12： | 0 |
| 3 | Effect of continuous positive airway pressure ventilation on nocturnal ST-segment changes in patients with sleep-disordered breathing显示文摘Objective To determine whether sleep-disordered breathing (SDB) may lead to nocturnal myocardial ischemia and whether the severity of this ischemia may be relieved by nasal continuous positive airway pressure (CPAP). Methods Overnight polysomnogram examination and simultaneous 3-channel Holter monitoring were performed on 76 patients with moderate to severe SDB and no history of coronary heart disease. All the cases were treated with CPAP for one night. ST depression was defined as a ST segment decrease of more than 1 mm from baseline and lasting 1 min or more. The total duration (minutes) of ST depression was indexed to the total sleep time (minutes per hour of sleep). Results Twenty-eight patients (37%) showed ST segment depression during their sleep. Before CPAP treatment, the respiratory disturbance index (RDI) and arousal index were significantly higher during periods of ST depression than when ST segments were isoelectric, whereas no significant difference was found in blood oxygen saturation (SaO2). After the CPAP treatment of patients with ST depression, the duration of ST depression was significantly reduced from 36.8±18.9 to 11.4±13.2 min/h (P<0.05). ST depression-related indexes, including RDI, arousal index and the percentage of sleep time spent at SaO2 below 90% (TS90/ TST), were all significantly decreased, with RDI from 63.4±23.8 to 8.1±6.6 /h, arousal index from 51.2±18.9 to 9.6±5.4 /h, and TS90/ TST from 50.6±21.4 to 12.9±14.7% (P<0.05). Conclusion ST-segment depression is rather common in patients with moderate to severe SDB, and CPAP treatment can significantly reduce the duration of ST depression. ST depression in these patients may reflect the myocardial ischemia that really exists and the non-ischemic changes associated with recurrent SDB. | Wenli Zhang Shiwen Wang Rui Chen Mohan Liu Lin Wang Lei Gao Caiyi Lu | 2007 | Journal of Geriatric Cardiology2007，4，2： | 0 |
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