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| 1 | Anti-inflammatory and anti-arthritic activity of type-A procyanidine polyphenols from bark of Cinnamomum zeylanicum in rats显示文摘Type-A procyanidine polyphenols(TAPP)are reported to have immunomodulatory and anti-inflammatory potential in vitro.The objective of present work is to evaluate potential of TAPP extracted from Cinnamon(Cinnamomum zeylanicum)bark in animal models of inflammation and rheumatoid arthritis in rats.Carrageenan-induced rat paw edema(CPE)and adjuvant induced established arthritis(AIA),in rats were used as the experimental models for inflammation and arthritis respectively.Analgesic activity was evaluated in Randall–Selitto assay in AIA rats.TAPP showed significant anti-inflammatory effect at dose of 4,8 and 25 mg/kg,p.o.but not at 2 mg/kg,p.o.dose in CPE model.The dose of 8 mg/kg,p.o.was selected for the evaluation of anti-arthritic activity in AIA model.TAPP(8 mg/kg,p.o.,daily from day-12 to day-21)treatment in established arthritic rats showed significant reversal of changes induced in AIA with respect to body weight drop(cachexia),ankle diameter,arthritic score,serum C-reactive protein(CRP)levels.Moreover,TAPP was found to be non-ulcerogenic as compared to AIA control rats.However,TAPP did not show analgesic effect on AIA-induced pain as seen in Randall–Selitto assay.In conclusion,TAPP showed disease-modifying potential in animal models of inflammation and arthritis in rats.©2013 Beijing Academy of Food Sciences.Production and hosting by Elsevier B.V.All rights reserved. | Sachin Vetal Subhash L.Bodhankar Vishwaraman Mohan Prasad A.Thakurdesai | 2013 | Food Science and Human Wellness2013，2，2： | 8 |
| 2 | Anti-epileptic effect of morin against experimental pentylenetetrazol-induced seizures via modulating brain monoamines and oxidative stress显示文摘Objective: To evaluate the protective effect of morin against pentylenetetrazol(PTZ)-induced tonic-clonic convulsions in mice. Methods: Swiss albino mice(18-22 g) was used to induce convulsions by intraperitoneal(i.p.) administration of PTZ(90 mg/kg). Mice were either pretreated with morin(10, 20 and 40 mg/kg) or vehicle(distilled water, 10 mg/kg) 45 min before PTZ administration. Various behavioral and biochemical parameters were assessed. Results: PTZ administration resulted in significant production(P<0.001) of tonic-clonic conclusion and mortality in mice. PTZ-induced increase in the duration of convulsion, onset of convulsion and mortality was inhibited significantly by morin(20 and 40 mg/kg) administration. The PTZinduced decrease in brain GABA, dopamine and Na+K+ATPase levels and increase in xanthine oxidase activity were inhibited significantly by morin(20 and 40 mg/kg) treatment. The increased levels of malondialdehyde and nitric oxide level were significantly decreased by morin(20 and 40 mg/kg) treatment. Also, reduced levels of superoxide dismutase and glutathione were increased significantly by morin treatment. Conclusions: Results of the present study indicate that morin showed its anti-convulsant effect via modulating the levels of brain GABA, Na^+K^+ATPase, and oxido-nitrosative stress. Thus, morin can be a potential candidate for further clinical evaluations as an anti-epileptic agent. | Amit D.Kandhare Anwesha A.Mukherjee Subhash L.Bodhankar | 2018 | Asian Pacific Journal of Tropical Biomedicine2018，8，7： | 0 |
| 3 | Protective role of concomitant administration of flax lignan concentrate and omega-3-fatty acid on myocardial damage in doxorubicin-induced cardiotoxicity显示文摘The severe cardiotoxicity incurred due to doxorubicin limits the use of their therapeutic potential.The current study aims to investigate the cardioprotective effect of concomitant administration of flax lignan concentrate(FLC)and omega-3-fatty acid(ω-3-FA)on myocardial damage in doxorubicin-induced cardiotoxicity in Wistar rats.Cardiotoxicity was induced by intraperitoneal injection of doxorubicin(4 mg/kg)on day 7th,14th,21st and 28th day in normal saline.Concomitant administration of FLC(500 mg/kg)andω-3-FA(1 mL/kg)lowered TNF-αlevel,normalized ST,QT and mean arterial blood pressure,elevation in endogenous enzymes levels such as glutathione and lowering in malondialdehyde,super oxide dismutase followed by normalized lipid profile and reduced the mortality rate.The treatment had antiapoptotic potential at cellular level also histopathology of heart tissue(light and electron microscopical).Thus concomitant action of FLC andω-3-FA may be antioxidant,antihyperlipidemic,anti-inflammatory and anti-apoptotic actions seem to the probable mechanisms in doxorubicin induced cardiotoxicity.It can be concluded that FLC andω-3-FA both have distinct mechanism for cardioprotection and hence the additive effect was observed in the present study due to concomitant administration of FLC andω-3-FA.©2013 Beijing Academy of Food Sciences.Production and hosting by Elsevier B.V.All rights reserved. | Anand A.Zanwar Mahabaleshwar V.Hegde Subhash L.Bodhankar | 2013 | Food Science and Human Wellness2013，2，1： | 0 |
| 4 | Prophylactic effects of asiaticoside-based standardized extract of Centella asiatica(L.) Urban leaves on experimental migraine: Involvement of 5HT1A/1B receptors显示文摘The present study aimed at evaluation of prophylactic efficacy and possible mechanisms of asiaticoside(AS) based standardized extract of Centella asiatica(L.) Urban leaves(INDCA) in animal models of migraine. The effects of oral and intranasal(i.n.) pretreatment of INDCA(acute and 7-days subacute) were evaluated against nitroglycerine(NTG, 10 mg·kg-1, i.p.) and bradykinin(BK, 10 μg, intra-arterial) induced hyperalgesia in rats. Tail flick latencies(from 0 to 240 min) post-NTG treatment and the number of vocalizations post-BK treatment were recorded as a measure of hyperalgesia. Separate groups of rats for negative(Normal) and positive(sumatriptan, 42 mg·kg-1, s.c.) controls were included. The interaction of INDCA with selective 5-HT1 A, 5-HT1 B, and 5-HT1 D receptor antagonists(NAN-190, Isamoltane hemifumarate, and BRL-15572 respectively) against NTG-induced hyperalgesia was also evaluated. Acute and sub-acute pre-treatment of INDCA [10 and 30 mg·kg-1(oral) and 100 μg/rat(i.n.) showed significant anti-nociception activity, and reversal of the NTG-induced hyperalgesia and brain 5-HT concentration decline. Oral pre-treatment with INDCA(30 mg·kg-1, 7 d) showed significant reduction in the number of vocalization. The anti-nociceptive effects of INDCA were blocked by 5-HT1 A and 5-HT1 B but not 5-HT1 D receptor antagonists. In conclusion, INDCA demonstrated promising anti-nociceptive effects in animal models of migraine, probably through 5-HT1A/1B medicated action. | Vijeta Bobade Subhash L.Bodhankar Urmila Aswar Vishwaraman Mohan Prasad Thakurdesai | 2015 | Chinese Journal of Natural Medicines2015，13，4： | 0 |
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