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| 1 | Ghrelin attenuates gastrointestinal epithelial damage induced by doxorubicin显示文摘AIM:To examine the influence of ghrelin on the regenerative potential of gastrointestinal(GI)epithelium.METHODS:Damage to GI epithelium was induced in mice by two intravenous injections of doxorubicin(10 and 6 mg/kg).Some of the doxorubicin-treated mice received a continuous subcutaneous infusion of ghrelin(1.25μg/h)for 10 d via implanted mini-osmotic pumps.To label dividing stem cells in the S-phase of the cell cycle,all mice received a single intraperitoneal injection of 5'-bromo-2'-deoxyuridine(BrdU)one hour before sacrifice.The stomach along with the duodenum were then removed and processed for histological examination and immunohistochemistry using anti-BrdU antibody.RESULTS:The results showed dramatic damage to the GI epithelium 3 d after administration of chemotherapy which began to recover by day 10.In ghrelintreated mice,attenuation of GI mucosal damage was evident in the tissues examined postchemotherapy.Immunohistochemical analysis showed an increase in the number of BrdUlabeled cells and an alteration in their distribution along the epithelial lining in response to damage by doxorubicin.In mice treated with both doxorubicin and ghrelin,the number of BrdUlabeled cells was reduced when compared with mice treated with doxorubicin alone.CONCLUSION:The present study suggests that ghrelin enhances the regenerative potential of the GI epithelium in doxorubicintreated mice,at least in part,by modulating cell proliferation. | Mohamed A Fahim Hazem Kataya Rkia El-Kharrag Dena AM Amer Basel al-Ramadi Sherif M Karam | 2011 | World Journal of Gastroenterology2011，17，33： | 3 |
| 2 | Consensus statement on the epidemiology,diagnosis,prevention,and management of cow's milk protein allergy in the Middle East:a modified Delphi-based study显示文摘Background This study aimed to develop an expert consensus regarding the epidemiology,diagnosis,and management of cow’s milk protein allergy(CMPA)in the Middle East.Methods A three-step modified Delphi method was utilized to develop the consensus.Fifteen specialized pediatricians participated in the development of this consensus.Each statement was considered a consensus if it achieved an agreement level of>80%.Results The experts agreed that the double-blind placebo-controlled oral challenge test(OCT)should be performed for 2-A weeks using an amino acid formula(AAF)in formula-fed infants or children with suspected CMPA.Formula-fed infants with confirmed CMPA should be offered a therapeutic formula.The panel stated that an extensively hydrolyzed formula(eHF)is indicated in the absence of red flag signs.At the same time,the AAF is offered for infants with red flag signs,such as severe anaphylactic reactions.The panel agreed that infants on an eHF with resolved symptoms within 2-4 weeks should continue the eHF with particular attention to the growth and nutritional status.On the other hand,an AAF should be considered for infants with persistent symptoms;the AAF should be continued if the symptoms resolve within 2-4 weeks,with particular attention to the growth and nutritional status.In cases with no symptomatic improvements after the introduction of an AAF.other measures should be followed.The panel developed a management algorithm,which achieved an agreement level of 90.9%.Conclusion This consensus document combined the best available evidence and clinical experience to optimize the management of CMPA in the Middle East. | Moustafa A.El-Hodhod Mortada H.F.El-Shabrawi Ahmed AIBadi Ahmed Hussein AM Almehaidib Basil Nasrallah Ebtsam Mohammed AIBassam Hala El Feghali Hasan M.Isa Khaled Al Saraf Maroun Sokhn Mehdi Adeli Najwa Mohammed Mousa Al-Sawi Pierre Hage Suleiman Al-Hammadi | 2021 | World Journal of Pediatrics2021，17，6： | 3 |
| 3 | Epideivnal growth factor receptor in colorectal carcinoma:correlation with clinicopathological prognostic factors显示文摘 | Abd HS Mishfiky AM Mohamed FA | 2008 | Colorectal Dis2008，10，2： | 1 |
| 4 | Epidermal growth factor receptor in colorectal carcinoma: correla- tion with clinieo - pathological prognostic factors 显示文摘 | Abd E1 All HS Mishriky AM Mohamed FA | 2008 | Colorectal Dis2008，10，2： | 1 |
| 5 | Plasma neutrophil gelatinase-associated lipocalin as an early biomarker for prediction of acute kidney injury after cardio-pulmonary bypass in pediatric cardiac surgery显示文摘 | Fadel FI Abdel Rahman AM Mohamed MF | 2012 | Arch Med Sci2012，8，2： | 1 |
| 6 | Mechanical stretch up-regu- lates microRNA-26a and induces human airway smooth muscle hy- pertrophy by suppressing glycogen synthase kinase-3β 显示文摘 | Mohamed JS Lopez MA Boriek AM | 2010 | J Biol Chem2010，285，29： | 1 |
| 7 | Computational approach involving use of the internal transcribed spacer 1 region for identification of Mycobacterium species显示文摘 | Mohamed AM Kuyper DJ Iwen PC | | 0，，08： | 1 |
| 8 | Epidermal growth factor receptor in colorectal carcinoma: correlation with clinico - pathological prognostic factors 显示文摘 | Abd E1 All HS Mishriky AM Mohamed FA | 2008 | Colorectal Dis2008，10，2： | 1 |
| 9 | Needlestick injuries among health care workers of University of Alexandria Hospitals 显示文摘 | Hanafi MI Mohamed AM Kassem MS | 2011 | East Mediterr Health J2011，17，1： | 1 |
| 10 | Bone mineral density in premenopausal Arab women with type 2 diabetes mellitus显示文摘 | Gupta R Mohammed AM Mojiminiyi OA | 2009 | Clin Densitom2009，12，1： | 1 |
| 11 | Mechanical stretch up-regulates microRNA-26a and induces human airway smooth muscle hypertrophy by suppressing glycogen synthase kinase-3beta显示文摘 | Mohamed JS Lopez MA Boriek AM | 2010 | J Biol Chem2010，285，29： | 1 |
| 12 | Epidermal growth factor receptor in colorectal carcinoma:correlation with clinico-pathological prognostic factors显示文摘 | Abd HS Mishriky AM Mohamed FA | 2008 | Colorectal Dis2008，10，2： | 1 |
| 13 | Effect of surgical approach on the early outcome of total hip replacement for femoral neck fractures显示文摘 | Mohamed AM Makki D Gibbs J | 2013 | Acta Orthop Belg2013，79，6： | 1 |
| 14 | Vasoactive mediators( VEGF and TNF-alpha) in patients with malignant and tuberculous pleural effusions 显示文摘 | Hamed EA E1-Noweihi AM Mohamed AZ | 2004 | Respirology2004，9，1： | 1 |
| 15 | Cyclin D1 gene amplification in proliferating haemangioma显示文摘 | Mohamed AM Elwakil TF Taher IM | | 0，，01： | 1 |
| 16 | Body image disturbance and surgical decision making in egyptian post menopausal breast cancer patients 显示文摘 | Shoma AM Mohamed MH Nouman N | 2009 | World Journal of Surgical Oncology2009，7，： | 1 |
| 17 | Acute mes-enteric ischaemia显示文摘 | Menon NJ Amin AM Mohammed A | 2005 | Acta Chir Belg2005，105，4： | 1 |
| 18 | Comparison of transvaginal uhrasonography and vaginal sonohysterography in the detection of endometrial polyps 显示文摘 | Kamel HS Darwish AM and Mohamed SA | 2000 | Acta Obstet Gynecol Scand2000，79，1： | 1 |
| 19 | Bone mineral density in premenopausal arab women with type 2 diabetes mellitus显示文摘 | Gupta R Mohammed AM Mojiminiyi OA | 2009 | J Clin Densitom2009，12，1： | 1 |
| 20 | Vasoactive mediators (VEGF and TNF-alpha) in patients with malignant and tuberculous pleural effusions显示文摘 | Hamed EA E1-Noweihi AM Mohamed AZ | 2004 | Respirology2004，9，1： | 1 |
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