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| 1 | Brain stem cells as the cell of origin in glioma显示文摘Glioma incidence rates in the United States are near 20000 new cases per year, with a median survival time of 14.6 mo for high-grade gliomas due to limited therapeutic options. The origins of these tumors and their many subtypes remain a matter of investigation. Evidence from mouse models of glioma and human clinical data have provided clues about the cell types and initiating oncogenic mutations that drive gliomagenesis, a topic we review here. There has been mixed evidence as to whether or not the cells of origin are neural stem cells, progenitor cells or differentiated progeny. Many of the existing murine models target cell populations defined by lineage-specific promoters or employ lineagetracing methods to track the potential cells of origin. Our ability to target specific cell populations will likely increase concurrently with the knowledge gleaned from an understanding of neurogenesis in the adult brain. The cell of origin is one variable in tumorigenesis, as oncogenes or tumor suppressor genes may differentially transform the neuroglial cell types. Knowledge of key driver mutations and susceptible cell types will allow us to understand cancer biology from a developmental standpoint and enable early interventional strategies and biomarker discovery. | Aram S Modrek N Sumru Bayin Dimitris G Placantonakis | 2014 | World Journal of Stem Cells2014，6，1： | 12 |
| 2 | Glioblastoma stem cells:Molecular characteristics and therapeutic implications显示文摘Glioblastoma Multiforme(GBM)is a grade IV astrocytoma,with a median survival of 14.6 mo.Within GBM,stem-like cells,namely glioblastoma stem cells(GSCs),have the ability to self-renew,differentiate into distinct lineages within the tumor and initiate tumor xenografts in immunocompromised animal models.More importantly,GSCs utilize cell-autonomous and tumor microenvironment-mediated mechanisms to overcome current therapeutic approaches.They are,therefore,very important therapeutic targets.Although the functional criteria defining GSCs are well defined,their molecular characteristics,the mechanisms whereby they establish the cellular hierarchy within tumors,and their contribution to tumor heterogeneity are not well understood.This review is aimed at summarizing current findings about GSCs and their therapeutic importance from a molecular and cellular point of view.A better characterization of GSCs is crucial for designing effective GSCtargeted therapies. | Nermin Sumru Bayin Aram Sandaldjian Modrek Dimitris George Placantonakis | 2014 | World Journal of Stem Cells2014，6，2： | 3 |
| 3 | A genomic view of alternative splicing显示文摘 | Modrek B Lee C | 2002 | Nat Genet2002，30，1： | 1 |
| 4 | T helper type 2- driven inflammation defines major subphenotypes of asthma 显示文摘 | Woodruff PG Modrek B Choy DF | 2009 | Am J Respir Crit Care Med2009，180，： | 1 |
| 5 | T-helper type 2-driven inflammation defines major subphenotypes of asthma显示文摘 | Woodruff PG Modrek B Choy DF | | 0，，： | 1 |
| 6 | Alternative splicing in the human, mouse and rat genomes is associated with an increased rate of exon creation/loss显示文摘 | Modrek B Lee CJ | 2003 | Nature2003，34，2： | 1 |
| 7 | A genomic view of alternative splicing显示文摘 | Modrek B Lee C | 2002 | Nat Genet2002，30，1： | 1 |
| 8 | T-helper type 2-driven inflammation defines major subphenotypes of asthma显示文摘 | Woodruff PG Modrek B Choy DF | | 0，，05： | 1 |
| 9 | ASAP: the alternative splicing annotation project显示文摘 | Lee C Atanelov L Modrek B | 2003 | Nucleic Acids Res2003，31，1： | 1 |
| 10 | Association of systemic lu- pus erythematosus with C8orfl3-BLK and ITGAM-ITGAX 显示文摘 | Horn G Graham RR Modrek B | 2008 | N Engl J Med2008，358，9： | 1 |
| 11 | A genomic view of alternative splicing 显示文摘 | MODREK B LEE C | 2002 | Nat Genet2002，30，1： | 1 |
| 12 | T-helper type 2-driven inflammation defines major subphenotypes of asthma 显示文摘 | Woodruff PG Modrek B Choy DF | 2009 | AmJ Respir Crit Care Med2009，180，： | 1 |
| 13 | T-helper type 2- driven inflammation defines major subphenotypes of asth- ma显示文摘 | Woodruff PG Modrek B Choy DF | 2009 | Am J Respir Crit Care Med2009，180，5： | 1 |
| 14 | Association of systemic lupus erythematosus with C8orf13-BLK and IT-GAM-ITGAX显示文摘 | Graham RR Modrek B | 2008 | N Engl J Med2008，358，： | 1 |
| 15 | Association of systemic lupus erythematosus with C8orfl3 - BLK and ITGAM - ITGAX显示文摘 | HOM G GRAHAM R R MODREK B | 2008 | N Engl J Med2008，358，9： | 1 |
| 16 | As-sociation of systemic lupus erythematosuswith C8orfl3-BLK and ITGAM-ITGAX显示文摘 | Horn G Graham RR Modrek B | 2008 | N Engl J Med2008，358，9： | 1 |
| 17 | TH2-driven inflamma- tion defines major subphenotypes of asthma 显示文摘 | Woodruff PG Modrek B Choy DF | 2009 | Am J Respir Crit Care Med2009，180，5： | 1 |
| 18 | A genomic view of alternative spli cing 显示文摘 | Modrek B Lee C | 2002 | Nature Genetics2002，30，1： | 1 |
| 19 | Genome-wide detection of alternative splicing in expressed sequences of human genes显示文摘 | Modrek B Resch A Grasso C | 2001 | Nucleic Acid Res2001，29，13： | 1 |
| 20 | A genomic view of alternative splicing 显示文摘 | Modrek B Lee C | 2002 | Nat Genet2002，30，1： | 1 |
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