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3篇 您的检索式：作者名="Mo Yanling"

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		题名	作者	年代	出处	被引量
	1	Thrombin is a therapeutic target for non-small-cell lung cancer to inhibit vasculogenic mimicry formation显示文摘Tumor cells transform into endothelial cells by epithelial-to-mesenchymal transition,which is characterized by vasculogenic mimicry(VM).VM not only accelerates tumor progression but also increases drug-induced resistance.However,very little is currently known about the molecular determinants that enable VM.Targeting VM might bring a new breakthrough in cancer treatment.Thrombin is the key enzyme of the blood coagulation system and could contribute to tumor progression.Nevertheless,the association between thrombin and VM formation remains largely unknown.We found that VM was associated with the overall survival of non-small-cell lung cancer(NSCLC)patients,and that thrombin expression was closely related to VM formation.This research revealed that thrombin induced VM formation via PAR-1-mediated NF-κB signaling cascades.The novel thrombin inhibitors r-hirudin and DTIP inhibited VM formation and spontaneous metastases in subcutaneous tumors.Clinical pathological analysis confirmed that NSCLC patients with thrombin-positive/PAR-1-high expression had the poorest prognosis and were the most likely to form VM.The promotional activity of thrombin in VM formation and tumor metastasis was abolished in PAR-1-deficient NSCLC cells.The EGFR inhibitor gefitinib had no effect on VM and increased VEGF expression in tumors.The combination therapy of DTIP and gefitinib achieved a better therapeutic effect than either agent alone.This study is the first to illustrate that thrombin substantially contributes,together with PAR-1,to VM formation and to illustrate that VM might be a target of r-hirudin and DTIP to suppress tumor progression.The anticoagulants r-hirudin and DTIP could be employed for antitumor therapy.Combination therapy with DTIP with an EGFR inhibitor might achieve superior therapeutic effects.	Bing Zhao Mengfang Wu Zhihuang Hu Yixin Ma Wang Qi Yanling Zhang Yaran Li Min Yu Huijie Wang Wei Mo	2020	Signal Transduction and Targeted Therapy2020，5，1：	2
	2	Functional properties of a novel mutant of staphylokinase with platelet-targeted fibrinolysis and antiplatelet aggregation activities显示文摘	Chen Hongshan Mo Wei Zhang Yanling	2007	European Journal of Phyarmacology2007，566，：	1
	3	Phylogenetic and molecular characterization of coxsackievirus A24variant isolates from a 2010acute hemorrhagic conjunctivitis outbreak in Guangdong,China显示文摘	Wu De Zheng Huanying Li Hui Monagin Corina Guo Xue Liu Leng Zeng Hanri Fang Ling Mo Yanling Zhou Huiqiong Zhang Huan Kou Jing Long Caiyun Hiromu Yoshida and Ke Changwen	2012	Virol J2012，9，41：	1

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