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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Interesting physical properties of the new spinel phase of Si《,3》N《,4》 and C《,3》N《,4》显示文摘 | Ouyang L Z and Ching W Y | 1999 | Physical Review Letters1999，83，： | 1 |
| 3 | Zircon U-Pb dating and in-si- tu Hf isotopic analysis of Permian peraluminous granite in the Lha- sa terrane, southern Tibet: Implications for Permian collisional orogeny and paleogeography显示文摘 | Zhu D C Mo X X Niu Y L | 2009 | Tectonophysics2009，469，14： | 1 |
| 4 | Theoretical prediction of the structure and properties of cubic spinel nitrides显示文摘 | Mo S D Ouyang L Z | 2002 | Journal of the American Ceramic Society2002，85，： | 1 |
| 5 | Predicting the ther mal conductivity of multiple carbon fillers in polypropylene- based resins 显示文摘 | Gaxiola D L Keith J M Mo Na | 2011 | J Compos Mater2011，45，12： | 1 |
| 6 | Undetstanding PRRSV Infection in Porcine Lung Based on Genome-Wide Transcriptome Response Identified by Deep Sequencing显示文摘 | Xiao S Q Jia J Y Mo D L | 2010 | PLoS ONE2010，5，6： | 1 |
| 7 | Heterometallic coordination polymers generated from tripodal metalloligands显示文摘 | Li D J Mo L Q Wang Q M | 2011 | Inorganic Chemistry Communications2011，14，7： | 1 |
| 8 | Interesting physical properties of the new spinel phase of Si3 N4 and C3N4显示文摘 | MO S D OUYANG L CHING W Y | 1999 | Phys Rev Lett1999，83，24： | 1 |
| 9 | 显示文摘 | Zhang L D Mo C M | 1995 | Nanostructured Materials1995，6，58： | 1 |
| 10 | Geochemical investigation of Early Cretaceous igneous rocks along an east-west traverse throughout the central Lhasa Terrane, Tibet显示文摘 | Zhu D C Mo X X Niu Y L Zhao Z D Wang L Q Liu Y S Wu F Y | 2009 | Chem Geol2009，268，34： | 1 |
| 11 | The Lhasa Terrane: Record of a microcontinent and its histories of drift and growth显示文摘 | Zhu D C Zhao Z D Niu Y L Mo X X Chung S-L Hou Z Q Wang L Q Wu F Y | 2011 | Earth Planet Sci Lett2011，301，12： | 1 |
| 12 | Lipopolysaecha- ride-induced miR-1224 negatively regulates turnout necrosis fac- tor-alpha gene expression by modulating Spl 显示文摘 | Niu Y Mo D Qin L Wang C Li A Zhao X | 2011 | Immunology2011，，： | 1 |
| 13 | Interesting Physical Properties of the New Spinel Phase of Si3N4 and C3N4显示文摘 | Mo S D Ouyang L Z Ching W Y | 1999 | Physical Review Letters1999，83，： | 1 |
| 14 | Effects of Dodecylamine and Dodecanethiol on the Conductive Properties of Nano-Ag Films显示文摘 | Mo L Liu D Li W | 2011 | Applied Surface Science2011，257，： | 1 |
| 15 | F l u i d –solid interaction simulation of flow and stress pattern inthoracoabdominal aneurysms:a patient-specific study显示文摘 | B o r g h i A Wo o d NB Mo h i a d d i n RH e t a l | 2008 | JFluids Struct2008，24，2： | 1 |
| 16 | Undetstanding PRRSV infection in porcine lung based on genome-wide transcriptome response identified by deep sequendng显示文摘 | Xiao S Q Jia J Y Mo D L | 2010 | PLoS ONE2010，5，： | 1 |
| 17 | Seismic retrofit of hollow rectangular bridge columns显示文摘 | Mo Y L Yeh Y K Hsieh D M | 2004 | Journal of Composites for Construction2004，8，1： | 1 |
| 18 | The 132 Ma ComeiBunbury large igneous province:Remnants identified in presentday southeastern Tibet and southwestern Australia显示文摘 | ZHU D C CHUNG S L MO X X | 2009 | Geology2009，37，7： | 1 |
| 19 | Preparation of β-SiC nanorods with and without amporphous SiO2 wrapping layers 显示文摘 | Meng G W Zhang L D Mo C M | 1998 | J Mater Res1998，13，9： | 1 |
| 20 | Effects of accelerated carbonation on the microstrueture of Portland cement pastes containing reactive MgO 显示文摘 | MO L PANESAR D K | 2012 | Cem Concr Res2012，42，6： | 1 |
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