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| 1 | Brazilin from Caesalpinia sappan heartwood and its pharmacological activities:A review显示文摘Caesalpinia sappan L.(CS) is a plant of Leguminosae family,commonly known as Brazil or Sappan wood.CS is distributed in Southeast Asia and its dried heartwood has been used as traditional ingredient of food or beverages and has a wide variety of medicinal properties.Higher extraction yield of CS wood was achieved with 95% ethanol for 2 h.Chemical constituent's investigation of sappan wood resulled in the isolation of various structural types of phenolic components including one xanihone,one coumarin,three chalcones,two flavones three homoisoflavonoids and brazilin.Brazilin[(6a S-cis)-7,11b-dihydrobcnz[b]indeno[1.2-d]pyran-3.6a.9.10(6H)- tetroll.a major and active compound found in CS heartwood.Most of the folkloric uses of brazilin were validated by the scientific studies such as antioxidant,antibacterial,anti-inflammatory,anti-photoaging.hypoglycemic,vasorelaxant,hepatoproteetive and anti-acne activity.CS heartwood extract is safe and did not produce any acute or subacute toxicity in both male and female rats.Brazilin is the safe natural compound having potential to develop as a medicinal compound with application in food,beverage,cosmetics and pharmaceutical industries to screen its clinical use in modern medicine.The information gained could provide the important and potential approach for pharmaceutical researcher to implicate the knowledge of brazilin in the formulation of new drug and to reveal therapeutic and gaps requiring future research opportunities.More studies are needed to evaluate the potential application of brazilin as preservative and coloring agent in food processing industries. | Nilesh P Nirmal Mithun S Rajput Rangabhatla G.S.V.Prasad Mehraj Ahmad | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，6： | 14 |
| 2 | Autologous mobilized peripheral blood CD34^+ cell infusion in non-viral decompensated liver cirrhosis显示文摘AIM: To study the effect of mobilized peripheral blood autologous CD34 positive(CD34+) cell infusion in patients with non-viral decompensated cirrhosis.METHODS: Cirrhotic patients of non-viral etiology were divided into 2 groups based on their willingness to be listed for deceased donor liver transplant(DDLT)(control, n = 23) or to receive autologous CD34+ cell infusion through the hepatic artery(study group, n= 22). Patients in the study group were admitted to hospital and received granulocyte colony stimulating factor injections 520 μg/d for 3 consecutive days to mobilize CD34+ cells from the bone marrow. On day 4,leukapheresis was done and CD34+ cells were isolated using CliniMAC magnetic cell sorter. The isolated CD34+ cells were infused into the hepatic artery under radiological guidance. The patients were discharged within 48 h. The control group received standard of care treatment for liver cirrhosis and were worked up for DDLT as per protocol of the institute. Both groups were followed up every week for 4 wk and then every month for 3 mo.RESULTS: In the control and the study group, the cause of cirrhosis was cryptogenic in 18(78.2%) and16(72.72%) and alcohol related in 5(21.7%) and6(27.27%), respectively. The mean day 3 cell count(cells/μL) was 27.00 ± 20.43 with a viability of 81.84± 11.99%. and purity of 80%-90%. Primary end point analysis revealed that at 4 wk, the mean serum albumin in the study group increased significantly(2.83± 0.36 vs 2.43 ± 0.42, P = 0.001) when compared with controls. This improvement in albumin was,however, not sustained at 3 mo. However, at the end of3 mo there was a statistically significant improvement in serum creatinine in the study group(0.96 ± 0.33 vs 1.42 ± 0.70, P = 0.01) which translated into a significant improvement in the Model for End-Stage Liver Disease score(15.75 ± 5.13 vs 19.94 ± 6.68,P = 0.04). On statistical analysis of secondary end points, the transplant free survival at the end of 1 mo and 3 mo did not show any significant difference(P =0.60) when compared to the control group. There was no improvement in aspartate transaminase, alanine transaminase, and bilirubin at any point in the study population. There was no mortality benefit in the study group. The procedure was safe with no procedural or treatment related complications.CONCLUSION: Autologous CD 34+ cell infusion is safe and effectively improves liver function in the short term and may serve as a bridge to liver transplantation. | Mithun Sharma Padaki Nagaraja Rao Mitnala Sasikala Mamata Reddy Kuncharam Chimpa Reddy Vardaraj Gokak BPSS Raju Jagdeesh R Singh Piyal Nag D Nageshwar Reddy | 2015 | World Journal of Gastroenterology2015，21，23： | 9 |
| 3 | Genetics of non-alcoholic fatty liver disease: From susceptibility and nutrient interactions to management显示文摘Genetics plays an important role in determining the susceptibility of an individual to develop a disease. Complex, multi factorial diseases of modern day(diabetes, cardiovascular disease, hypertension and obesity) are a result of disparity between the type of food consumed and genes, suggesting that food which does not match the host genes is probably one of the major reasons for developing life style diseases. Non-alcoholic fatty liver is becoming a global epidemic leading to substantial morbidity. While various genotyping approaches such as whole exome sequencing using next generation sequencers and genome wide association studies have identified susceptibility loci for non-alcoholic fatty liver disease(NAFLD) including variants in patatin-like phospholipase domain containing 3 and transmembrane 6 superfamily member 2 genes apart from others; nutrient based studies emphasized on a combination of vitamin D, E and omega-3 fatty acids to manage fatty liver disease. However majority of the studies were conducted independent of each other and very few studies explored the interactions between the genetic susceptibility and nutrient interactions. Identifying such interactions will aid in optimizing the nutrition tailor made to an individual's genetic makeup, thereby aiding in delaying the onset of the disease and its progression. The present topic focuses on studies that identified the genetic susceptibility for NAFLD, nutritional recommendations, and their interactions for better management of NAFLD. | Vishnubhotla Venkata Ravi Kanth Mitnala Sasikala Mithun Sharma Padaki Nagaraja Rao Duvvuru Nageshwar Reddy | 2016 | World Journal of Hepatology2016，8，20： | 3 |
| 4 | Molecular mechanisms of 5-HT 3 and NK 1 receptor antagonists in prevention of emesis显示文摘 | Camilo Rojas Mithun Raje Takashi Tsukamoto Barbara S. Slusher | 2014 | European Journal of Pharmacology2014，，： | 2 |
| 5 | Inhibition of ADP-induced platelet aggregation and involvement of non-cellular blood chemical mediators are responsible for the antithrombotic potential of the fruits of Lagenaria siceraria显示文摘AIM: The fruits of Lagenaria siceraria(Molina) Standl.(Cucurbitaceae), a commonly used vegetable, are reported to possess various medicinal properties. In previous studies, the fibrinolytic potential of an ethanolic extract of fruits of Lagenaria siceraria was investigated in comparison with kaempferol isolated from it. The aim of the present study was to explore its mechanistic antithrombotic potential and antiplatelet activity using a wide dose range in different in vitro and in vivo models, and to quantify the total phenolic, flavonoid, and kaempferol contents using a colorimetric method. METHOD: The antithrombotic potential was investigated using tail bleeding time in mice, a plasma recalcification assay, and pulmonary thromboembolism in mice. The antiplatelet activity was studied using an in vitro model to investigate IC50 value. RESULTS: A significant amount of total phenols, flavonoids, and kaempferol was quantified in L. siceraria ethanolic extract. An ethanolic extract of the fruits of L. siceraria showed a significant increase in tail bleeding time and plasma recalcification time, significant protection against ADP induced pulmonary thromboembolism in mice, and also inhibited the platelet aggregation induced by ADP in vitro. The study suggested that the fruits of L. siceraria exhibit significant antithrombotic potential due to inhibition of ADP-mediated platelet aggregation and the involvement of various non-cellular chemical mediators of blood. CONCLUSION: This finding may be helpful in treating the serious consequences of the thrombus formed in blood vessels which include atherothrombotic diseases, such as myocardial or cerebral infarction. So, further investigation should be done for revealing exact mechanism of action behind these types of activities. | Mithun Singh Rajput Neelam Balekar Dinesh Kumar Jain | 2014 | Chinese Journal of Natural Medicines2014，12，8： | 2 |
| 6 | 一种改进的DIQaM_FR/NR图像质量评价模型显示文摘图像质量评价模型通过提取并分析与人类视觉系统相一致的图像特征来达到评价图像质量的目的。随着深度学习技术的发展,很多基于深度学习的图像质量评价模型相继出现,但是多数模型在小数据量环境下容易出现过拟合问题。为此,通过对DIQaM_FR/NR模型进行改进,建立一种Res-DIQaM_FR/NR图像质量评价模型。采用迁移学习方法,利用预训练的ResNet50网络替代DIQaM_FR/NR的特征提取层以进行图像特征提取,使用全局平均池化层取代DIQaM_FR/NR中的全连接层FC-512从而对提取的特征进行回归学习。实验结果表明,该模型在降低DIQaM_FR/NR模型复杂度的同时能够深化其网络结构,在小数据量环境下也能较好地模拟人类视觉系统并准确评价图像质量。 | 谢瑞 邵堃 霍星 MITHUN Md Masud Parvej | 2020 | 计算机工程2020，46，8： | 2 |
| 7 | Microwave, ultrasonic and chemo-mechanical pretreatments for enhancing methane potential of pulp mill wastewater treatment sludge显示文摘 | Mithun Saha Cigdem Eskicioglu Juan Marin | 2011 | Bioresource Technology2011，，17： | 2 |
| 8 | Sturctural ordering and magnetic properties of Fel0o~Ga, alloys显示文摘 | Himalay Basumatary Mithun Palit Arout Chelvane J | 2008 | Scripta Materialia2008，59，7： | 1 |
| 9 | Disorder trapping in gas quenched magnetostrictive Fe-Ga alloys 显示文摘 | Himalay Basumatary Mithun Palit Arout Chelvane J | 2010 | Materials Science and Engineering B2010，167，6： | 1 |
| 10 | Barnett, SGLT-2 Inhi-bitors in Development for Type 2 Diabetes Treatment显示文摘 | Mithun Bhartia Abd A Tahrani Anthony H | 2011 | The Reviewof Diabetic Sdudies2011，8，3： | 1 |
| 11 | 锆英石对铝铬锆砖抗侵蚀性能及六价铬形成的影响显示文摘铝铬锆砖因具有优异的抗渣侵蚀性能,被作为炉衬材料广泛应用于工作环境恶劣的危废焚烧炉。然而,铝铬锆砖在制备和服役过程中可能形成有毒的水溶性Cr(Ⅵ),相关研究工作却未见报道。本研究分别以单斜氧化锆和锆英石为氧化锆源制备了两种铝铬锆砖,研究了铝铬锆砖在四种不同组成危废焚烧炉渣中的侵蚀行为及熔渣侵蚀前后砖中Cr(Ⅵ)的含量。结果表明,锆英石高温下分解形成单斜氧化锆和无定形的二氧化硅,促进化学稳定性较好的(Al,Cr)2O3固溶体的形成,提高了铝铬锆砖的致密化程度,同时改善了铝铬锆砖的抗渣侵蚀性能。此外,生成的二氧化硅可以还原砖中Cr(Ⅵ)化合物,降低铝铬锆砖中的Cr(Ⅵ)含量。熔渣侵蚀后,铝铬锆砖渗透层中Cr(Ⅵ)含量与熔渣成分密切相关。在被高碱性氧化物含量的熔渣侵蚀后,铝铬锆砖渗透层中的Cr(Ⅵ)含量较高,但锆英石作为氧化锆源的铝铬锆砖在不同熔渣中侵蚀前后的原砖层和渗透层内的Cr(Ⅵ)含量均低于欧盟限制标准。 | 徐腾腾 徐义彪 Mithun NATH 李亚伟 张文辉 张卫星 张晟 | 2020 | 硅酸盐通报2020，39，12： | 1 |
| 12 | 基于启发搜索空间遗传算法的安全控制最优潮流方法(英文)显示文摘提出了一种新的可用于安全控制最优潮流问题的遗传算法。该算法应用了一个全新的启发式搜索空间技术,具有更快的收敛速度,缩减了计算的负担。实验采用IEEE 30 bus系统,并以传统的简单遗传算法(SGA),自适应遗传算法(AGA),粒子群技术(PSO),差别演变(DE)作为进行实验比较,结果表明,在具有以及不具有(N-1)断电的偶然性的实例分析中,本文所提算法有更好的鲁棒性,在优化问题上有较好的应用前景。 | Mithun M Bhasskar Mohan Benerji Sydulu M | 2011 | 昆明理工大学学报(自然科学版)2011，36，3： | 1 |
| 13 | Convenient one pot synthesis of some novel derivatives of thiazolodihydropyrimidinone possessing 4-methylthiophenyl moiety and evaluation of their antibacterial and antifungal activities显示文摘 | Mithun A Bantwal S H Nalilu S K | 2007 | European Journal of Medicinal Chemistry2007，42，： | 1 |
| 14 | Detection and classification of vehicles from video using multiple time-spatial images 显示文摘 | Mithun N C Rashid N U Rahman S M | 2012 | IEEE Trans on Intelligent Transportation Systems2012，13，3： | 1 |
| 15 | Synthesis and antimicrobial activities of some new triazolothiadiazoles beating 4- methyl-thiobenzyl moiety 显示文摘 | carbonic Jagadeesh D P Mithun A Prakash K | 2009 | Eur J Med Chem2009，44，2： | 1 |
| 16 | Non-small cell lung carcinoma(NSCLC):Implications on molecular pathology and advances in early diagnostics and therapeutics显示文摘Continuous revision of the histologic and stage-wise classification of lung cancer by the World Health Organization (WHO) provides the foundation for therapeutic advances by promoting molecular targeted and immunotherapies and ensuring accurate diagnosis. Cancer epidemiologic data provide helpful information for cancer prevention, diagnosis, and management, supporting health-care interventions. Global cancer mortality projections from 2016 to 2060 show that cancer will overtake ischemic heart diseases (IHD) as the leading cause of death (18.9 million) immediately after 2030, surpassing non-small cell lung cancer (NSCLC), which accounts for 85 percent of lung cancers. The clinical stage at the diagnosis is the main prognostic factor in NSCLC therapies. Advanced early diagnostic methods are essential as the initial stages of cancer show reduced mortality compared to the advanced stages. Sophisticated approaches to proper histological classification and NSCLC management have improved clinical efficiency. Although immune checkpoint inhibitors (ICIs) and targeted molecular therapies have refined the therapeutic management of late-stage NSCLC, the specificity and sensitivity of cancer biomarkers should be improved by focusing on prospective studies, followed by their use as therapeutic tools. The liquid biopsy candidates such as circulating tumor cells (CTCs), circulating cell-free tumor DNA (cfDNA), tumor educated platelets (TEP), and extracellular vesicles (EVs) possess cancer-derived biomolecules and aid in tracing: driver mutations leading to cancer, acquired resistance caused by various generations of therapeutic agents, refractory disease, prognosis, and surveillance. | Hafiza Padinharayil Jinsu Varghese Mithun Chacko John Golgodu Krishnamurthy Rajanikant Cornelia M.Wilson Minnatallah Al-Yozbaki Kaviyarasi Renu Saikat Dewanjee Rupa Sanyal Abhijit Dey Anirban Goutam Mukherjee Uddesh Ramesh Wanjari Abilash Valsala Gopalakrishnan Alex George | 2023 | Genes & Diseases2023，10，3： | 1 |
| 17 | Sturctural ordering and magnetic properties of Fe100-XGaX alloys显示文摘 | Himalay Basumatary Mithun Palit J Arout Chelvane | 2008 | Scripta Materialia2008，59，： | 1 |
| 18 | Selective Fluorogenic and Chromogenic Probe for Detection of Silver Ions and Silver Nanoparticles in Aqueous Media显示文摘 | Amrita C Mithun S Nayoun W | 2009 | J Am Chem Soc2009，131，： | 1 |
| 19 | Seripta Materialia显示文摘 | Mithun Pali | 2009 | 60:562009，60，： | 1 |
| 20 | Security constraint optimal power flow (scopf)-a comprehensive survey显示文摘 | MITHUN B M MUTHYALA S MAHESWARAPU S | 2010 | International Journal of Computer Applications2010，6，8： | 1 |
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