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| 1 | Local Proinflammatory Effects of Repeated Skin Exposure to Warfarin, An Anticoagulant Rodenticide in Rats显示文摘Objective: To evaluate the effects of epicutaneous application of anticoagulant warfarin, by examining the presence of tissue injury and immune/inflammatory activity in exposed skin. Methods: Rats were exposed to warfarin by applying 10 μg of warfarin‐sodium to 10‐12 cm 2 skin (range 0.8‐1 μg per 1 cm 2 ) for 3 consecutive days. Tissue injury was evaluated by lipid peroxidation, histomorphological changes and signs of reparative activity in skin. T cell infiltration and selected aspects of epidermal cell activity were examined as indicators of immune/inflammatory skin response to warfarin application. Results: Repeated warfarin application exerted no effect on skin metabolic viability, but resulted in tissue injury (increased malondialdehyde, MDA, production, evident histo‐morphological changes in epidermis and dermis depicting cell injury and death). Increased numbers of proliferating cell nuclear antigen (PCNA + ) cells indicated reparative processes in injured skin. Infiltration of CD3 + cells (T lymphocytes) along with the increased production of tumor necrosis factor‐α (TNF‐α) by epidermal cells from warfarin‐treated skin and their co‐stimulatory effect in an in vitro T‐cell activation assay demonstrated immunomodulatory effects of epicutaneous warfarin. Conclusion: Presented data have documented tissue damage associated with immune/ inflammatory activity in skin exposed to warfarin. Observed effects are relevant to immunotoxic potential of this anticoagulant in settings of external exposure. | Aleksandra POPOV Ivana MIRKOV Lidija ZOLOTAREVSKI Milena JOVIC Sandra BELIJ Dragan KATARANOVSKI Milena KATARANOVSKI | 2011 | Biomedical and Environmental Sciences2011，24，2： | 13 |
| 2 | Pulmonary Immune Responses to Aspergillus Fumigatus in Rats显示文摘Objective To evaluate immunologic mechanisms underlying Aspergillus fumigatus pulmonary infections in immunocompetent Dark Agouti(DA) and Albino Oxford(AO) rats recognized as being susceptible to some inflammatory diseases in different manners. Methods Lung fungal burden(quantitative colony forming units, CFU, assay), leukocyte infiltration(histology, cell composition) and their function(phagocytosis, oxidative activity, CD11 b adhesion molecule expression) and cytokine interferon-γ(IFN-γ) and interleukin-17 and-4(IL-17 and IL-4) lung content were evaluated following infection(intratracheally, 1x107 conidia). Results Slower reduction of fungal burden was observed in AO rats in comparison with that in DA rats, which was coincided with less intense histologically evident lung cell infiltration and leukocyte recovery as well as lower level of most of the their activities including intracellular myeloperoxidase activity, the capacity of nitroblue tetrazolium salt reduction and CD11 b adhesion molecule expression(except for phagocytosis of conidia) in these rats. Differential patterns of changes in proinflammatory cytokine levels(unchanged levels of IFN-γ and transient increase of IL-17 in AO rats vs continuous increase of both cytokines in DA rats) and unchanged levels of IL-4 were observed. Conclusion Genetically-based differences in the pattern of antifungal lung leukocyte activities and cytokine milieu, associated with differential efficiency of fungal elimination might be useful in the future use of rat models in studies of pulmonary aspergillosis. | MIRKOV Ivana EL-MUZGHI Amal Atia Mhfuod DJOKIC Jelena NINKOV Marina POPOV ALEKSANDROV Aleksandra GLAMOCLIJA Jasmina KATARANOVSKI Milena | 2014 | Biomedical and Environmental Sciences2014，27，9： | 2 |
| 3 | Anatomic considerations in lmnbar postcrolateral percutaneous procedures 显示文摘 | Mirkovic SR Schwartz DG Glazier KD | 1995 | Spine1995，1520，18： | 1 |
| 4 | Multimodality therapy for stage III non - small - cell lung cancer 显示文摘 | Farray D Mirkovic N Albain KS | 2005 | J Clin Oncol2005，23，14： | 1 |
| 5 | Enterovirus etiology of the 1970Singapore epidemic ofacute conjunctivitis显示文摘 | Mirkovic R R Schmidt N J Yin-Murphy M | 1974 | Intervirology1974，4，2： | 1 |
| 6 | Thermodynamic aspects of grain refinement of Al-Si alloys using Ti and B显示文摘 | Grboner J Mirkovic D Schmid-Fetzer R | 2005 | Materials Science and Engineering A2005，395，12： | 1 |
| 7 | Thermodynamic aspects of grain refinement of Al-Si alloys using Ti and B 显示文摘 | Grobner J Mirkovic D Schmid-Fetzer R | 2005 | Mater Sci Eng A2005，395，： | 1 |
| 8 | Vitamin D in chronic kidney disease:new potential for intervention显示文摘 | Mirkovic K Van den Born J Navis G | 2011 | Curr Durg Targets2011，12，1： | 1 |
| 9 | The development of genetic transgenic transformation of sugarcane in Texas 显示文摘 | IRVINE J E MIRKOV T E | 1997 | Sugar Journal1997，60，： | 1 |
| 10 | Posttranscriptional Gene Silencing in Transgenic Sugarcane显示文摘 | Ivan L Ingelbrecht James E Irvine T Erik Mirkov | 1999 | Plant Physiol1999，119，4： | 1 |
| 11 | Drosophila nemo is an essential gene involved in the regulation of programmed cell death显示文摘 | Ivana Mirkovic Kristi Charish Sharon M Gorski Kristen McKnight Esther M Verheyen | 2002 | Mechanisms of Development2002，，1： | 1 |
| 12 | Spinal Stenosis显示文摘 | Garfin SR Herkowitz HV Mirkovic S | 2000 | Instr Course Lect2000，49，： | 1 |
| 13 | Multimodality therapy for stage' Ⅲ non-small-cell lung cancer 显示文摘 | Farray D Mirkovic N Albain K S | 2005 | J Clin Oncol2005，23，14： | 1 |
| 14 | A taxonomy of DDoS attacks and DDoS defense mechanisms 显示文摘 | MIRKOVIC J MARTIN J PEIHER P | 2004 | ACM Sigcomm Computer Comm2004，34，2： | 1 |
| 15 | Analyses of genotypic diversity a- mong North, South, and Central American isolates of sugar- cane yellow leaf virus:evidence for Colombian origins and for intraspecific spatial phy|ogenetic variation 显示文摘 | Moonan F Mirkov T E | 2002 | J Virol2002，76，3： | 1 |
| 16 | D-WARD: a source-end defense against flooding denial-of-service attaeks显示文摘 | Mirkovic J Reiher P | 2005 | IEEE Trans on Depend- able and Secure Computing2005，2，3： | 1 |
| 17 | Characterization of a new vacuolar membrane aquaporin sensitive to mercury at a unique site显示文摘 | DANIELS M J CHAUMONT F MIRKOV T E | 1996 | Plant Cel1996，8，4： | 1 |
| 18 | Anatomic consideration for sacral screw placement显示文摘 | Mirkovic S Abitbol JJ Steinman J | 1991 | Spine1991，16，6： | 1 |
| 19 | Neurosarcoidosis:Two case reports with multiple cranial nerve involvement and review of the literature显示文摘 | Mijajlovic M Mirkovic M Mihailovic-Vucinic V | 2013 | Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub2013，158，4： | 1 |
| 20 | Relation between 25 ( OH )-vitamin D deficiency and markers of bone formation and resorption in haemodialysis patients显示文摘 | Milinkovic NLj Majkic Singh NT Mirkovic DI) | 2009 | Clin Lab2009，55，910： | 1 |
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