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| 1 | A comparison between previous and present histologic assessments of chronic hepatitis C viral infections in humans显示文摘METHODSLiverbiopsiesfrom79untreatedpatientswerereviewed.AntiHCVtestinghadbeenperformedbyELISAandconfirmedbyarecombinantimm... | N Assy 1 and GY Minuk 2 | 1999 | World Journal of Gastroenterology1999，5，2： | 24 |
| 2 | Role of traditional Chinese medicine in the management of patients with hepatocellular carcinoma显示文摘Traditional Chinese Medicines(TCMs) have been employed for centuries in the treatment of patients with hepatocellular carcinoma(HCC). Previous reviews of this topic have focused on certain aspects of TCM treatment rather than an overall assessment of their value and mechanisms of action. Both the Chinese and English medical literatures were reviewed to identify where TCM might be of value in the treatment of HCC and the justification for such treatment. TCM treatment corrects the 'internal disequilibriums' thought to be responsible for the development, growth, and spread of the tumor. It has also been used to manage symptoms associated with HCC and the adverse effects of chemo-and radiation-therapies. Recent research has documented the precise effects of TCM on tumor biology. There are also increasing efforts to identify which of the many components of TCM herbal remedies are primarily responsible for these beneficial effects. This review outlines the benefits of TCM treatment of HCC and the laboratory data describing their anti-tumor properties. | Sheng-Yan Xi Gerald Yosel Minuk | 2018 | World Journal of Hepatology2018，10，11： | 20 |
| 3 | Appearance of an inhibitory cell nuclear antigen in rat and human serum during variable degrees of hepatic regenerative activity显示文摘METHODSInanimalstudies,adultmaleSpragueDawleyrats(n=3-4/group)weresacrificedat0,12,24,36,48,72and96hoursfollowing70%partia... | N Assy 1,2 ,YW Gong 3,M Zhang 3 and GY Minuk 3,4 | 1999 | World Journal of Gastroenterology1999，5，2： | 6 |
| 4 | 肝星状细胞中细胞凋亡和存活的信号调控(英文)显示文摘肝星状细胞(hepatic stellate cells,HSCs)在肝脏纤维化发生过程中起着关键作用。当正常肝脏受到损伤时,HSCs由静息状态转分化为类肌成纤维细胞,并保持这种处于激活状态的表型,它们接收到的凋亡和存活的生物信号将决定激活态HSCs的最终细胞寿命。HSCs凋亡的发生与一系列复杂而又相互关联的生物信号传导和调控有关,HSCs凋亡信号来自于细胞膜受体,如死亡受体、神经生长因子受体和外周型苯甲二氮卓受体(peripheral-type benzodiazepine receptor) ;以及胞浆蛋白,如Bcl-2家族蛋白和细胞周期蛋白等。HSCs存活信号受到多种激酶和细胞因子的诱导,如金属蛋白酶组织抑制剂-1(tissue inhibitors of metalloproteinase-1)、Rho/Rho激酶、血小板源生长因子(platelet-derived growth factor)、转化生长因子-β1 (transforming growth factor-β1 )和胰岛素样生长因子(insulin-like growth factor-1)等。特异性地诱导HSCs发生凋亡是治疗肝脏纤维化的直接和有效手段,虽然目前对HSCs由激活态到静息状态的转归尚需进一步研究,但诱导HSCs凋亡将是治疗肝脏纤维化和肝硬化的研究热点和主要发展方向。 | Hong Shen Jianghong Fan Geraid Minuk Yuewen Gong | 2007 | 中南大学学报(医学版)2007，32，5： | 2 |
| 5 | Randomized Controlled Trial of Total Immunosuppression Withdrawal in Liver Transplant Recipients: Role of Ursodeoxycholic Acid显示文摘 | Nimer Assy Paul C. Adams Paul Myers Verra Simon Gerry Y. Minuk William Wall Cameron N. Ghent | 2007 | Transplantation2007，，12： | 2 |
| 6 | Research towards safer resection of the cirrhotic liver显示文摘 | Moser MA Kneteman NM Minuk GY | 2000 | HBP Surgery2000，11，5： | 1 |
| 7 | Predictive vale of soluble intercellular adhesion molecule-1 for risk of ischemic event in individuals with cerebrovascular disease 显示文摘 | Ehrensperger E Minuk J Durcan L | 2005 | Cerebrovasc Dis2005，20，6： | 1 |
| 8 | Shear stress-induced nitric oxide release triggers the liver regeneration cascade显示文摘 | Schoen JM Wang HH Minuk GY | 2001 | Nitric Oxide2001，5，5： | 1 |
| 9 | Randomised trial of interferon a2b plus ribavirin for 48 weeks or for 24 weeks versus interferon a2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus显示文摘 | Poynard T Mareellln P Lee SS Minuk GS Ideo G Bain V Heathcote J Zeuzem S Trepo C Albrecht J | | 0，，： | 1 |
| 10 | Glucoregulatory and metabolic response to exercise in obese noninsulin-dependent diabetes显示文摘 | Vranic M Marliss E | 1981 | Am J Physiol1981，240，： | 1 |
| 11 | Occult hepatitis B Virus infection in a North American community-based population显示文摘 | Minuk Gy Sun DF | | 0，，04： | 1 |
| 12 | Insulin-like growth factors (IGF) in liver disease: differential changes of IGF- Ⅰ and IGF-Ⅱ 显示文摘 | Sheppard MS Minuk GY Bhaumick B | 1987 | Clin Invest Med1987，10，2： | 1 |
| 13 | Effects of Hepatic Stimulator Substance HerbalMedicine,Selenium/Vitamin E,and Ciprofloxacin on Cirrhosis in theRat显示文摘 | Zhang Manna Song Guopei Minuk G Y | 1996 | Gastroenterology1996，110，： | 1 |
| 14 | The metabolic syndrome and all- cause mortality in an insured lives population显示文摘 | Pinkham C A Cumming M E Minuk | 2006 | North American Actuarial Journal2006，10，3： | 1 |
| 15 | Occult hepatitis B virus in- fection in a North American community - based population 显示文摘 | Minuk GY Sun DF Ubranova J | 2009 | J Hepatol2009，21，12： | 1 |
| 16 | Research towards safer resection of the cirrhotic liver显示文摘 | Moser MA Kneteman NM Minuk GY | 2000 | HBP Surgery2000，11，5： | 1 |
| 17 | Liver regeneration: methods for monitoring and their applications 显示文摘 | Assy N Minuk GY | 1997 | J Hepatol1997，26，4： | 1 |
| 18 | Comparison of glyceraldehyde-3-phosphatedehydrogenase and 28s-ribosomal RNA gene expression in human hep-atocellular carcinoma显示文摘 | Gong Y Cui L Minuk GY | 1996 | Hepatology1996，23，4： | 1 |
| 19 | Fihromuscular dysplasia with carotid artery dissection presenting as an isolated hemianopsia 显示文摘 | Poppe A Y Minuk J Glikstein R | 2007 | J Stroke Cerebrovasc Dis2007，16，3： | 1 |
| 20 | Apoptotic and survivalsignals in hepatic stellate cells显示文摘 | Shen H Fan JH Minuk G | 2007 | Zhong Nan Da XueXue Bao Yi Xue Ban2007，32，5： | 1 |
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