|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Human ESC-derived expandable hepatic organoids enable therapeutic liver repopulation and pathophysiological modeling of alcoholic liver injury显示文摘We report the generation of human ESC-derived,expandable hepatic organoids(hEHOs)using our newly established method with wholly defined(serum-free,feeder free)media.The hEHOs stably maintain phenotypic features of bipotential liver stem/progenitor cells that can differentiate into functional hepatocytes or cholangiocytes.The hEHOs can expand for 20 passages enabling large scale expansion to cell numbers requisite for industry or clinical programs.The cells from hEHOs display remarkable repopulation capacity in injured livers of FRG mice following transplantation,and they differentiate in vivo into mature hepatocytes.If implanted into the epididymal fat pads of immune-deficient mice,they do not generate non-hepatic lineages and have no tendency to form teratomas.We further develop a derivative model by incorporating human fetal liver mesenchymal cells(hFLMCs)into the hEHOs,referred to as hFLMC/hEHO,which can model alcoholic liver disease-associated pathophysiologic changes,including oxidative stress generation,steatosis,inflammatory mediators release and fibrosis,under ethanol treatment.Our work demonstrates that the hEHOs have considerable potential to be a novel,ex vivo pathophysiological model for studying alcoholic liver disease as well as a promising cellular source for treating human liver diseases. | Shuyong Wang Xuan Wang Zuolong Tan Yuxin Su Juan Liu Mingyang Chang Fang Yan Jie Chen Tao Chen Chuanjiang Li Jie Hu Yunfang Wang | 2019 | Cell Research2019，29，12： | 20 |
| 2 | Terahertz metasurface zone plates with arbitrary polarizations to a fixed polarization conversion显示文摘Metasurfaces that can realize the polarization manipulation of electromagnetic waves on the sub-wavelength scale have become an emerging research field.Here,a novel strategy of combining the metasurface and Fresnel zone plate to form a metasurface zone plate is proposed to realize the conversion from nearly arbitrary polarizations to a fixed polarization.Specifically,when one polarized wave is incident on adjacent ring zones constructed by different types of meta-atoms,the transmitted waves generated by odd-numbered and even-numbered ring zones converge at the same focus and superimpose to generate a fixed polarized wave.As function demonstrations,we have designed two types of metasurface zone plates:one is a focused linear polarizer,and the other can convert nearly arbitrary polarized waves into focused circularly polarized waves.The simulated and measured results are consistent with theoretical expectations,suggesting that the proposed concept is flexible and feasible.Our work provides an alternative platform for polarization manipulation and may vigorously promote the development of polarization photonic devices. | Zhen Yue Jitao Li Jie Li Chenglong Zheng Jingyu Liu Guocui Wang Hang Xu Mingyang Chen Yating Zhang Yan Zhang Jianquan Yao | 2022 | Opto-Electronic Science2022，1，3： | 9 |
| 3 | Effect of Sanhuangwuji powder,anti-rheumatic drugs,and ginger-partitioned acupoint stimulation on the treatment of rheumatoid arthritis with peptic ulcer:a randomized controlled study显示文摘OBjECTIVE:To observe the efficacy and safety of oral Sanhuangwuji powder,anti-rheumatic drugs(ARDs),and ginger-partitioned acupoint stimulation at Zusanli(ST 36) on the treatment of rheumatoid arthritis(RA) complicated by peptic ulcer.METHODS:This prospective randomized controlled study included 180 eligible inpatients and outpatients randomly assigned to an ARD treatment(n = 60),ginger-partitioned stimulation(n =60),or combination treatment(n = 60).Patients assigned to the ARD group were given oral celecoxib,methotrexate,and esomeprazole.Patients assigned to theginger-partitioned stimulation group were given ginger-partitioned acupoint stimulation at Zusanli(ST 36) in addition to the ARDs.Patients in the combination treatment group were given oral Sanhuangwuji powder,ginger-partitioned acupoint stimulation at Zusanli(ST 36),and ARDs.All patients were followed up for 2 months to evaluate clinical effects and safety.The study was registered in the World Health Organization database at the General Hospital of Chengdu Military Area Command Chinese People's Liberation Army(ChiCTR-TCC12002824).RESULTS:The combination treatment group had significantly greater improvements in RA symptoms,laboratory outcomes,and gastrointestinal symptom scores,compared with the other groups(P < 0.05).The peptic ulcer healing rate in the combination treatment group was significantly greater than that in the ARD treatment group(x^2 = 16.875,P < 0.05) and the ginger-partitioned stimulation group(x^2 = 6.171,P<0.05).CONCLUSION:Combination treatment with ginger-partitioned acupoint stimulation at Zusanli(ST36),oral Sanhuangwuji powder,and ARDs had a better clinical effect for RA with complicated peptic ulcer,compared with ARD treatmentalone or in combination with ginger-partitioned acupoint stimulation. | Liu Defang Guo Mingyang Hu Yonghe Liu Taihua Yan Jiao Luo Yong Yun Mingdong Yang Min Zhang Jun Guo Linglin | 2015 | Journal of Traditional Chinese Medicine2015，35，3： | 9 |
| 4 | Distribution and existing state of indium in the Gejiu Tin polymetallic deposit, Yunnan Province, SW China显示文摘The Gejiu tin polymetallic deposit, located in the southwest margin of the South China Belt bordering on the Yangtze Block, is hosted in Triassic carbonates. This study shows that there is an indium enrichment in the ores.Indium mainly exists in sphalerite-rich massive sulfide ores with a concentration of 198.3–1570 ppm; the indium concentration in sphalerite ranges from 493.3 up to4781 ppm. The inferred indium reserve in the Gejiu Sn deposit is over 4000 t, indicating that the Gejiu tin deposit is a giant In-bearing Sn-polymetallic deposit, similar to the Dachang and Dulong in southwest China. Sphalerite with a high Fe value(8.05–13.27 wt%) is the predominant indium carrier mineral; meanwhile chalcopyrite plays the secondary indium carrier role. EPMA mapping result shows that indium is likely distributed homogeneously and presented as a substitution for Zn in sphalerite. | Yubang Li Yan Tao Feilin Zhu Mingyang Liao Feng Xiong Xianze Deng | 2015 | Chinese Journal Of Geochemistry2015，34，4： | 7 |
| 5 | Effect of methotrexate combined with Sanhuang Yilong decoction on serum and synovial fluid aquaporin levels in rheumatoid arthritis dampness-heat blockage syndrome显示文摘OBJECTIVE:To study the effect of methotrexate(MTX) combined with Sanhuang Yilong decoction(SYD) on aquaporin(AQP) expression,and to explore the role of AQPs in the pathogenesis of rheumatoid arthritis(RA).METHODS:A total of 118 dampness-heat blockage type RA patients who were hospitalized in the General Chengdu Military Hospital between January2014 and December 2016 were selected as subjects in this study(30 patient of these patients with knee joint effusion were assigned to the RA synovial fluid group).For the pre-treatment controlgroups,30 healthy volunteers were recruited as the healthy control group and 30 osteoarthritis(OA) patients with knee joint effusion were included as OA synovial fluid control group.The RA dampnessheat blockage syndrome treatment groups were divided into 45 cases in the combined group and 45 cases in the MTX group.The combined group received MTX combined with SYD treatment while the MTX group received MTX alone.AQP1,AQP2 and AQP3 expressions were detected in the serum and synovial fluid.RESULTS:AQP1 had the highest expression,followed by AQP3,and AQP2.The serum levels of AQP1,AQP2 and AQP3 were all significantly lower than those in the healthy volunteers(P < 0.05),while the synovial fluid AQP1,AQP2 and AQP3 expression in the RA group were comparable to these in the OA groups(P > 0.05).After treatment for2 weeks,serum AQP1,AQP2,AQP3 were significantly increased and erythrocyte sedimentation rate,C-reactive protein,disease activity score of 28 joints were decreased in the combined group(P < 0.05).CONCLUSION:Abnormal expression of AQPs inhibits water metabolism in RA dampness-heat blockage syndrome,so liquid is accumulated at the joint,which may play an important role in the pathogenesis of RA.MTX combined with SYD for the treatment of RA can effectively increase AQP expression. | Liu Defang Yan Jiao Guo Mingyang Luo Yong Yang Mei Yang Min Zou Longfu Li Wan Zhong Xiaolong Liu Tao Hu Yonghe | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 6 | Effect of Sanhuangyilong decoction plus methotrexate on tumor necrosis factor alpha and interferon gamma in serum and synovial fluid in rheumatoid arthritis patients with symptom pattern of damp heat obstruction显示文摘OBJECTIVE: To investigate the effect of Sanhuangyilong decoction plus methotrexate(MTX) on Interferon gamma(IFN-γ) and tumor necrosis factor alpha(TNF-α) in the serum and synovial fluid of rheumatoid arthritis(RA) patients with damp-heat-obstruction symptom pattern, Sanhuangyilong decoction and the role of TNF-α and IFN-γ in the development of RA.METHODS: RA inpatients with damp-heat-obstruction symptom pattern(partly with knee joint effusion) were selected as the research subjects. Before the treatment, healthy subjects and osteoarthritis(OA) patients with knee joint effusion were assigned to the serum control group and the synovial fluid control group, respectively; during the treatment, RA patients with damp-heat-obstruction symptom pattern were divided into two groups:one is combined group that was administered Sanhuangyilong decoction plus MTX; the other group was MTX group that received MTX only. The expression levels of TNF-α and IFN-γ in the serum and synovial fluid were measured with enzyme-linked immunosorbent assay(ELISA) before and after the treatment, and the peripheral blood levels of erythrocyte sedimentation rate(ESR), C-reactive protein(CRP) and disease activity score in 28 joints(DAS28)were determined.RESULTS: Before treatment, the serum levels of TNF-α and IFN-γ in the RA patients with dampheat-obstruction symptom pattern were higher than those in healthy control group(P < 0.05).The expression levels of TNF-α and IFN-γ in the synovial fluid of the RA patients were higher than those in the serum of the RA patients(P < 0.05). The expression levels of TNF-α and IFN-γ in the synovial fluid of the RA patients were higher than those of the sy-novial fluid of the osteoarthritis patients(P < 0.05).The expression of TNF-α and IFN-γ in the serum and synovial fluid of the RA patients had no correlation with the inflammatory activity index ESR, CRP,or DAS28(P > 0.05). After 2 weeks of treatment, the expression level of TNF-α and IFN-γ in the combined group had increased, although the difference was not statistically significant(P > 0.05); in contrast, ESR, CRP, and DAS28 decreased, and the difference was statistically significant(P < 0.01). After 4 weeks of therapy, TNF-alpha and IFN-γ, ESR,CRP, and DAS28 in the combined group decreased compared with the before-treatment levels(P <0.01). After 2 w of treatment, the differences in the TNF-α and IFN-γ expression levels in the combined group were not statistically significant(P > 0.05)compared with that in the MTX group, although there were statistically significant differences in the ESR, CRP, and DAS28(P < 0.05). After 4 weeks of treatment, differences in TNF-α, IFN-γ, ESR, CRP, and DAS28 in the combined group compared with MTX group were statistically significant(P < 0.01).CONCLUSION: TNF-α and IFN-γ might be involved in the development of RA. The RA patients with damp-heat-obstruction symptom pattern show better benefits from the treatment of Sanhuangyilong decoction plus MTX, and the treatment is superior to that of using MTX only. | Liu Defang Yan Jiao Yun Mingdong Yang Ming Luo Yong Zhang Jun Guo Mingyang Yang Mei Yuan Weili Zou Wei Li Hua Hu Yonghe | 2016 | Journal of Traditional Chinese Medicine2016，36，5： | 4 |
| 7 | Spatiotemporal heterogeneity of phytoplankton diversity and its relation to water environmental factors in the southern waters of Miaodao Archipelago,China显示文摘To study the water quality influenced by the anthropogenic activities and its impact on the phytoplankton diversity in the surface waters of Miaodao Archipelago, the spatiotemporal variations in phytoplankton communities and the environmental properties of the surface waters surrounding the Five Southern Islands of Miaodao Archipelago were investigated, based on seasonal field survey conducted from November 2012 to August 2013. During the survey, a total of 109 phytoplankton species from 3 groups were identified in the southern waters of Miaodao Archipelago, of which 77 were diatoms, 29 were dinoflagellates, and 3 were chrysophytes. Species number was higher in winter(73), moderate in autumn(70), but lower in summer(31) and spring(27). The species richness index in autumn(5.92) and winter(4.28) was higher than that in summer(2.83) and spring(1.41).The Shannon-Wiener diversity index was high in autumn(2.82), followed by winter(1.99) and summer(1.92), and low in spring(0.07). The species evenness index in autumn(0.46) and summer(0.39) was higher than that in winter(0.32) and spring(0.02). On the basis of principal component analysis(PCA) and redundancy analysis(RDA), we found that dissolved inorganic nitrogen(DIN) and chemical oxygen demand(COD) in spring, COD in summer, p H in autumn, and salinity and oil pollutant in winter, respectively, showed the strongest association with the distribution of phytoplankton diversity. The spatial heterogeneity of the southern waters of Miaodao Archipelago was quite obvious, and three zones, i.e., northeastern, southwestern and inter-island water area, were identified by cluster analysis(CA) based on key environmental variables. | ZHENG Wei LI Fen SHI Honghua HUO Yuanzi LI Yan CHI Yuan GUO Zhen WANG Yuanyuan SHEN Chengcheng LIU Jian QIAO Mingyang | 2016 | Acta Oceanologica Sinica2016，35，2： | 3 |
| 8 | Study of oxygen fugacity during magma evolution and ore genesis in the Hongge mafic–ultramafic intrusion, the Panxi region, SW China显示文摘Economic concentrations of Fe–Ti oxides occurring as massive layers in the middle and upper parts of the Hongge intrusion are different from other layered intrusions(Panzhihua and Baima) in the Emeishan large igneous province, SW China. This paper reports on the new mineral compositions of magnetite and ilmenite for selected cumulate rocks and clinopyroxene and plagioclase for basalts. We use these data to estimate the oxidation state of parental magmas and during ore formation to constrain the factors leading to the abundant accumulation of Fe–Ti oxides involved with the Hongge layered intrusion. The results show that the oxygen fugacities of parental magma are in the range of FMQ-1.56 to FMQ+0.14, and the oxygen fugacities during the ore formation of the Fe–Ti oxides located in the lower olivine clinopyroxenite zone(LOZ) and the middle clinopyroxenite zone(MCZ) of the Hongge intrusion are in the range of FMQ-1.29 to FMQ-0.2 and FMQ-0.49 to FMQ+0.82, respectively.The MELTS model demonstrates that, as the oxygen fugacity increases from the FMQ-1 to FMQ+1, the proportion of crystallization magnetite increases from 11 % to 16 % and the crystallization temperature of the Fe–Ti oxides advances from 1134 to 1164 °C. The moderate oxygen fugacities for the Hongge MCZ indicate that the oxygen fugacity was not the only factor affecting the crystallization of Fe–Ti oxides. We speculated that theinitial anhydrous magma that arrived at the Hongge shallow magma chamber became hydrous by attracting the H_2O of the strata. In combination with increasing oxygen fugacities from the LOZ(FMQ-1.29 to FMQ-0.2) to the MCZ(FMQ-0.49 to FMQ+0.82), these two factors probably account for the large-scale Fe–Ti oxide ore layers in the MCZ of the Hongge intrusion. | Mingyang Liao Yan Tao Xieyan Song Yubang Li Feng Xiong | 2016 | Acta Geochimica2016，35，1： | 3 |
| 9 | Selectivity switch in transformation of CO2 from ethanol to methanol on Cu embedded in the defect carbon显示文摘The copper-based catalysts have been generally regarded as high-performance catalysts for CO_2 hydrogenation toward methanol,while the production of ethanol via C–C coupling on the copper-based catalysts is still challenging.Herein,we report a new catalyst where Cu nanoparticles are embedded in the carbon support with abundant defect sites,achieving a high selectivity for ethanol in the CO_2 hydrogenation.The experiments coupled with the theoretical studies show a clear map where carbon defects serve as anchor sites that can stabilize interfacial copper species,and interfacial Cu sites with low coordination numbers can adsorb two C_1 species and later convert them to a C_2 species via a hydrogenation-induced coupling reaction.Further adjacent Cu atoms of interfacial Cu sites can facilitate OH reduction reactions via the Cu–Cu bridge adsorption to assist the formation of ethanol.Especially,those specific active sites easily disappear in the reducing conditions and during the reaction,the major product can transform from ethanol to methanol. | Shuohao Li Govindarajan Saranya Mingyang Chen Yan Zhu | 2020 | Science China Chemistry2020，63，5： | 2 |
| 10 | Energetic particles’fluxes and dose in the Radiation Gene Box measured by space radiation detector onboard SJ-10 satellite显示文摘Background To evaluate the hazard of space radiation posing to the tissues,it is important to obtain exact fluxes of different radiation particles.The Radiation Gene Box(RGB)onboard SJ-10 spacecraft was an instrument designed to investigate the effects of space environment on the mESCs and drosophila.To derive the dose received by the tissues inside the RGB,the Space Radiation Detector(SRD)was installed inside it.Purpose The SRD was designed to derive the fluxes of electron,proton,hellion and gamma rays around it.If the type of the particles,the energies,the fluxes and the conversion coefficients are known,the dose received by the tissues could be evaluated.Methods The SRDwas designed as a △E-E solid-state telescope.By measuring the energy deposited in the three subdetectors,the particles’type and their energies could be discriminated.The data of SRDwere divided into 15 bins by the types of particles and their energy ranges.Results The gamma ray flux was higher than any other particle flux inside the RGB,and the electron was the most intense charge particle,while the helium ion was the most harmful radiation to the cells inside the RGB.Conclusion The dose rate inside the Radiation Gene Box was much higher than in the ground,but the integral dose of 12 days inside the RGB was about 2.13 mSv.It seemed unlikely to have obvious biological effects on the tissues of mice and drosophila. | Xingzhu Cui Yaqing Liu Wenxi Peng Jinzhou Wang Min Gao Dongya Guo Xiaohua Liang Ruirui Fan Huanyu Wang Yunlong Zhang Zhongjian Ma Mingyang Yan Hong Xiao Yuanda Jiang Haiying Hang | 2018 | Radiation Detection Technology and Methods2018，2，2： | 2 |
| 11 | Radiation shielding for the first optics enclosure at the High Energy Photon Source beamlines显示文摘Purpose The High Energy Photon Source(HEPS)is currently under construction in China and will be the brightest synchrotron radiation facility in the world.To solve the gas bremsstrahlung and synchrotron radiation hazard at HEPS beamlines,a comprehensive radiation study is performed.Method The Monte Carlo method is used to analyze the radiation field in the first optics enclosure at HEPS beamlines.First,the radiation sources including gas bremsstrahlung and synchrotron radiation are estimated.Then,the distribution of the radiation field in the hutch is calculated.Conservative parameters and a typical beamline geometry are used in the calculations.Finally,the shielding recommendations are summarized.Results and Conclusion In this paper,the considerations and bulk shielding design of the first optics enclosure at HEPS beamlines are described.The design satisfies the requirements of the radiation safety principles. | Pingcheng Liu Qiongyao Liu Zhongjian Ma Huijie Zhang Mingyang Yan Qingbin Wang | 2021 | Radiation Detection Technology and Methods2021，5，2： | 2 |
| 12 | Influence of target thickness on the generation of high-density ion bunches by ultrashort circularly polarized laser pulses显示文摘 | Yin Yan Yu Wei Yu Mingyang | 2008 | Phys Plasmas2008，15，09： | 1 |
| 13 | Research on Freeze Drying and High-temperature Molding in Medium-temperature Fluorocarbon Board显示文摘A research and test system for the carbon anode plate preparation technology was established to optimize the physical and chemical indicators of carbon anode plates,such as bulk density,resistivity,and compressive strength,and improve the operating cycle.In this study,a carbon plate was prepared via a combination of high-temperature molding and freeze drying using a formulation with asphalt content much lower than the industry standard.The experimental results show that the density of the carbon plate is increased by 0.02-0.04 g/cm^(3) by improving the drying method.The carbon plate prepared in the laboratory has a bulk density of 1.814 g/cm^(3),resistivity of 29.8μΩ·m,and compressive strength of 89.27 MPa.The bulk density,room-temperature resistivity,compressive strength,graphitization,and other key indices of the carbon plates made in the laboratory and those procured from a factory in Shanxi,Datong,were tested.Additionally,the specimens were analyzed using thermogravimetry-differential scanning calorimetry,scanning electron microscopy,and X-ray fluorescence.The laboratory-made carbon plates were superior to the factory specimens in terms of all the indicators tested.The process in this study improves the performance of the carbon anode plate and is used to provide technical support for electrolytic fluorine production in enterprises.The carbon plates prepared in the laboratory fully meet the process requirements of a medium-temperature electrolytic fluorine production line,which indicates the possibility of its use in the stable production of fluorine gas. | 张东 ZHANG Pan YAN Xuefang CHAN Mingyang 杨林 | 2021 | Journal of Wuhan University of Technology(Materials Science)2021，36，6： | 1 |
| 14 | Graphene-Based Photo-Fenton Catalysts for Pollutant Control显示文摘Water pollution is a global environmental issue with multi-dimensional infl uences on human life.Some strategies,such as photo-Fenton reaction,have been employed to remove recalcitrant pollutants.Two-dimensional(2D)graphene and its threedimensional(3D)confi gurations have attracted considerable attention as emerging carbon-based catalysts in photo-Fenton fi elds owing to their alluring properties in electron transfer,reactant adsorption,and light response.This review summarizes the recent developments in 2D and 3D graphene-based catalysts for photo-Fenton reactions.Their structures,characteristics,activity,and mechanisms are discussed.The conclusions and outlooks are proposed for the profound understanding of challenges and future directions. | Yan Bao Qingyun Yan Jiahui Ji Bocheng Qiu Jinlong Zhang Mingyang Xing | 2021 | Transactions of Tianjin University2021，27，2： | 1 |
| 15 | Optical property of iron binding to Suwannee River fulvic acid 显示文摘 | YAN Mingquan LI Mingyang WANG Dongsheng | 2013 | Chemosphere2013，91，7： | 1 |
| 16 | A'Moore's law'for fibers enables intelligent fabrics显示文摘Fabrics are an indispensable part of our everyday life.They provide us with protection,offer privacy and form an intimate expression of ourselves through their esthetics.Imparting functionality at the fiber level represents an intriguing path toward innovative fabrics with a hitherto unparalleled functionality and value.The fiber technology based on thermal drawing of a preform,which is identical in its materials and geometry to the final fiber,has emerged as a powerful platform for the production of exquisite fibers with prerequisite composition,geometric complexity and control over feature size.A'Moore's law'for fibers is emerging,delivering higher forms of function that are important for a broad spectrum of practical applications in healthcare,sports,robotics,space exploration,etc.In this review,we survey progress in thermally drawn fibers and devices,and discuss their relevance to'smart'fabrics.A new generation of fabrics that can see,hear and speak,sense,communicate,harvest and store energy,as well as store and process data is anticipated.We conclude with a critical analysis of existing challenges and opportunities currently faced by thermally drawn fibers and fabrics that are expected to become sophisticated platforms delivering value-added services for our society. | Shengtai Qian Mingyang Liu Yuhai Dou Yoel Fink Wei Yan | 2023 | National Science Review2023，10，1： | 1 |
| 17 | African swine fever virus MGF505-3R inhibits cGAS-STING-mediated IFN-βpathway activation by degrading TBK1显示文摘African swine fever virus(ASFV)is an important pathogen causing acute infectious disease in domestic pigs and wild boars that seriously endangers the global swine industry.As ASFV is structurally complex and encodes a large number of functional proteins,no effective vaccine has been developed to date.Thus,dissecting the mechanisms of immune escape induced by ASFV proteins is crucial.A previous study showed that the ASFV-encoded protein is an important factor in host immunity.In this study,we identified a negative regulator,MGF505-3R,that significantly downregulated cGAS/STING-and poly(dG:dC)-mediated IFN-βand interferon stimulation response element(ISRE)reporter activity and suppressed IFNB1 and IFIT2 mRNA levels.In addition,TBK1,IRF3 and IκBαphosphorylation levels were also inhibited.Mechanistically,MGF505-3R interacted with cGAS/TBK1/IRF3 and targeted TBK1 for degradation,thereby disrupting the cGAS-STING-mediated IFN-βsignaling pathway,which appears to be highly correlated with autophagy.Knockdown MGF505-3R expression enhanced IFN-βand IL-1βproduction.Taken together,our study revealed a negative regulatory mechanism involving the MGF505-3R-cGAS-STING axis and provided insights into an evasion strategy employed by ASFV that involves autophagy and innate signaling pathways. | Mingyang Cheng Jiawei Luo Yuetong Duan Yu Yang Chunwei Shi Yu Sun Yiyuan Lu Junhong Wang Xiaoxu Li Jianzhong Wang Nan Wang Wentao Yang Yanlong Jiang Guilian Yang Yan Zeng Chunfeng Wang Xin Cao | 2022 | Animal Diseases2022，2，3： | 1 |
| 18 | Subcellular localization and functional analyses of a PR10 protein gene from Vitis pseudoreticulata in response to Plasmopara viticola infection显示文摘 | Mingyang He Yan Xu Jiangling Cao Ziguo Zhu Yuntong Jiao Yuejin Wang Xin Guan Yazhou Yang Weirong Xu Zhenfang Fu | 2013 | Protoplasma2013，，1： | 1 |
| 19 | Machine learning discovery of distinguishing laboratory features for severity classification of COVID-19 patients显示文摘The exponential spread of COVID-19 worldwide is evident,with devastating outbreaks primarily in the United States,Spain,Italy,the United Kingdom,France,Germany,Turkey and Russia.As of 1 May 2020,a total of 3,308,386 confirmed cases have been reported worldwide,with an accumulative mortality of 233,093.Due to the complexity and uncertainty of the pathology of COVID-19,it is not easy for front-line doctors to categorise severity levels of clinical COVID-19 that are general and severe/critical cases,with consistency.The more than 300 laboratory features,coupled with underlying disease,all combine to complicate proper and rapid patient diagnosis.However,such screening is necessary for early triage,diagnosis,assignment of appropriate level of care facility,and institution of timely intervention.A machine learning analysis was carried out with confirmed COVID-19 patient data from 10 January to 18 February 2020,who were admitted to Tongji Hospital,in Wuhan,China.A softmax neural network-based machine learning model was established to categorise patient severity levels.According to the analysis of 2662 cases using clinical and laboratory data,the present model can be used to reveal the top 30 of more than 300 laboratory features,yielding 86.30%blind test accuracy,0.8195 F1-score,and 100%consistency using a two-way patient classification of severe/critical to general.For severe/critical cases,F1-score is 0.9081(i.e.recall is 0.9050,and precision is 0.9113).This model for classification can be accomplished at a mini-second-level computational cost(in contrast to minute-level manual).Based on available COVID-19 patient diagnosis and therapy,an artificial intelligence model paradigm can help doctors quickly classify patients with a high degree of accuracy and 100%consistency to significantly improve diagnostic and classification efficiency.The discovered top 30 laboratory features can be used for greater differentiation to serve as an essential supplement to current guidelines,thus creating a more comprehensive assessment of COVID-19 cases during the early stages of infection.Such early differentiation will help the assignment of the appropriate level of care for individual patients. | Yang Xiao Li Yan Mingyang Zhang Kent E.Pinkerton Haosen Cao Ying Xiao Wei Li Shuai Li Yancheng Wang Shusheng Li Zhiguo Cao Gary Wing-Kin Wong Hui Xu Hai-Tao Zhang | 2021 | IET Cyber-Systems and Robotics2021，3，1： | 1 |
| 20 | The atomic path for constructing single-helical superstructure of AuCu bimetallic nanoclusters显示文摘Single-helical or double-helical structures are common in living organisms.Helical assembly has been found in the artificial nanoparticles,but how they do so remains poorly understood.Here,we exploit atomically precise Au_(6)Cu_(6)bimetallic nanoparticles(or called nanoclusters)as building blocks to construct a single-helical Au_(12)Cu_(12)superstructure in an operative path,thereby providing access to currently elusive mechanistic pathways.We propose that the thermodynamically viable linearto-bent process at a couple of Au_(6)Cu_(6)nanoclusters imparted by the organic ligands seems to be critical for the helical-nanostructured arrangement of Au_(12)Cu_(12).This study could help to offer a new design rule for the exquisitely helical structure assembled from the artificial nanoparticles. | Ancheng Tang Xiao Cai Yong Liu Jun Hou Xu Liu Mingyang Chen Yan Zhu | 2023 | Aggregate2023，4，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员