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| 1 | Cell membrane-covered nanoparticles as biomaterials显示文摘Surface engineering of synthetic carriers is an essential and important strategy for drug delivery in vivo.However,exogenous properties make synthetic nanosystems invaders that easily trigger the passive immune clearance mechanism,increasing the retention effect caused by the reticuloendothelial systems and bioadhesion,finally leading to low therapeutic efficacy and toxic effects.Recently,a cell membrane cloaking technique has been reported as a novel interfacing approach from the biological/immunological perspective,and has proved useful for improving the performance of synthetic nanocarriers in vivo.After cell membrane cloaking,nanoparticles not only acquire the physiochemical properties of natural cell membranes but also inherit unique biological functions due to the presence of membrane-anchored proteins,antigens,and immunological moieties.The derived biological properties and functions,such as immunosuppressive capability,long circulation time,and targeted recognition integrated in synthetic nanosystems,have enhanced their potential in biomedicine in the future.Here,we review the cell membrane-covered nanosystems,highlight their novelty,introduce relevant biomedical applications,and describe the future prospects for the use of this novel biomimetic system constructed from a combination of cell membranes and synthetic nanomaterials. | Mingjun Xuan Jingxin Shao Junbai Li | 2019 | National Science Review2019，6，3： | 9 |
| 2 | Perspective of energy transfer from light energy into biological energy显示文摘Energy has always been the most concerned topic in the world due to the large consumption. Various types of energy have been exploited and developed to enhance the output amount so that high requirements can be met. Like the hydro-energy, wind energy, and tidal energy, light energy as a renewable, clean, and widespread energy can be easily harvested. In microcosmic scale, some specific proteins and enzymes in green plants and bacteria play an important role in light harvest and energy conversion via photosynthesis. Inspired by the biomimetic sparks,these bioactive macromolecules and some artificially synthetic unites have been integrated together to improve the light-harvesting, and enhance their utilization efficiency. In this feature article, we primarily discuss that how to create the bio-inorganic hybrid energy converted system via biomimetic assembly strategy and artificially achieve the transformation from light into bioenergy, meanwhile highlight some promising works. | Mingjun Xuan Jie Zhao Jingxin Shao Qi Li Junbai Li | 2017 | Green Energy & Environment2017，2，1： | 2 |
| 3 | Reconstitution of Motor Proteins through Molecular Assembly显示文摘What is the most favorite and original chemistry developed in your research group?The most favorite and original chemistry developed in my research group is about the reconstitution of motor proteins in artificially designed and assembled units.It is based on the molecular assembly technique,but the method is different from the conventional approach. | Yi Jia Mingjun Xuan Xiyun Feng Li Duan Jieling Li Junbai Li | 2020 | Chinese Journal of Chemistry2020，38，2： | 1 |
| 4 | Experimental Study on Heavy Oil Drag Reduction in Horizontal Pipelines by Water Annular Conveying显示文摘Transportation of heavy oil by the so-called water-ring technique is a very promising method by which pressure drop and pollution can be significantly reduced.Dedicated experiments have been carried out by changing the phase’s density,viscosity,velocity and interfacial tension to systematically analyze the characteristics of the water ring.On the basis of such experimental data,a mathematical model for pressure drop prediction has been introduced.This research shows that as long as the density of oil and water remains the same,a concentric water ring can effectively be formed.In such conditions,the oil-water viscosity difference has little effect on the shape of water ring,and it only affects the pressure drop.The greater the viscosity of heavy oil,the smaller the pressure drop of the oil-water ring transportation system.The influence of phases’interfacial tension on the characteristics and pressure drop of the heavy oil-water ring can be considered negligible.The pressure drop prediction model introduced on the basis of the Buckingham’s principle provides values in good agreement(95%)with the experimental data. | Mingjun Du Jiaqiang Jing Xinqiang Xiong Bingbing Lang Xuan Wang Shiying Shi | 2022 | Fluid Dynamics & Materials Processing2022，18，1： | 0 |
| 5 | PhotosystemⅡ-based biomimetic assembly for enhanced photosynthesis显示文摘PhotosystemⅡ(PSⅡ)is a fascinating photosynthesis-involved enzyme,participating in sunlight-harvest,water splitting,oxygen release,and proton/electron generation and transfer.Scientists have been inspired to couple PSⅡwith synthetic hierarchical structures via biomimetic assembly,facilitating attainment of natural photosynthesis processes,such as photocatalytic water splitting,electron transfer and ATP synthesis,in vivo.In the past decade,there has been significant progress in PSⅡ-based biomimetic systems,such as artificial chloroplasts and photoelectrochemical cells.The biomimetic assembly approach helps PSⅡgather functions and properties from synthetic materials,resulting in a complex with partly natural and partly synthetic components.PSⅡ-based biomimetic assembly offers opportunities to forward semi-biohybrid research and synchronously inspire optimization of artificial light-harvest micro/nanodevices.This review summarizes recent studies on how PSⅡcombines with artificial structures via molecular assembly and highlights PSⅡ-based semi-natural biosystems which arise from synthetic parts and natural components.Moreover,we discuss the challenges and remaining problems for PSⅡ-based systems and the outlook for their development and applications.We believe this topic provides inspiration for rational designs to develop biomimetic PSⅡ-based semi-natural devices and further reveal the secrets of energy conversion within natural photosynthesis from the molecular level. | Mingjun Xuan Junbai Li | 2021 | National Science Review2021，8，8： | 0 |
| 6 | Ultrasound responsive microcapsules for antibacterial nanodrug delivery显示文摘The development of ultrasound-responsive microcapsule structures has resulted in several spatiotemporally controlled drug delivery systems for macromolecular cargoes,including proteins,nucleic acids,and even cells for biomedical applications.However,utilizing microcapsules to transport small molecular cargoes remains a challenge,because the leakage of drugs before ultrasound irradiation might cause side effects such as the undesired toxicity and the decrease of effective drug concentration at the target site.Herein,we present a novel strategy to tackle these shortcomings by employing nanodrugs which refers to nanoparticles coated with small molecule drugs.We showed that the drug leakage was prevented when encapsulating the nanodrug in microcapsules.Moreover,the fabricated drug delivery system was responsive not only to unfocused high-intensity ultrasound but also to the clinically relevant high-intensity focused ultrasound.Finally,as a proof of concept,we showed that the antibacterial activity of the nanodrug@Microcapsules could be activated by applying ultrasound in situ.These results may provide new insights into the development of ultrasound triggered small molecule drug delivery assisted by metallic nanoparticles. | Jilin Fan Mingjun Xuan Pengkun Zhao Mark Loznik Junlin Chen Fabian Kiessling Lifei Zheng Andreas Herrmann | 2023 | Nano Research2023，16，2： | 0 |
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