|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Construction of a small-caliber tissue-engineered blood vessel using icariin-loaded β-cyclodextrin sulfate for in situ anticoagulation and endothelialization显示文摘The rapid endothelialization of tissue-engineered blood vessels(TEBVs) can effectively prevent thrombosis and inhibit intimal hyperplasia. The traditional Chinese medicine ingredient icariin is highly promising for the treatment of cardiovascular diseases.β-cyclodextrin sulfate is a type of hollow molecule that has good biocompatibility and anticoagulation properties and exhibits a sustained release of icariin. We studied whether icariin-loaded β-cyclodextrin sulfate can promote the endothelialization of TEBVs. The experimental results showed that icariin could significantly promote the proliferation and migration of endothelial progenitor cells; at the same time, icariin could promote the migration of rat vascular endothelial cells(RAVECs). Subsequently,we used an electrostatic force to modify the surface of the TEBVs with icariin-loaded β-cyclodextrin sulfate, and these vessels were implanted into the rat common carotid artery. After 3 months, micro-CT results showed that the TEBVs modified using icariin-loaded β-cyclodextrin sulfate had a greater patency rate. Scanning electron microscopy(SEM) and CD31 immunofluorescence results showed a better degree of endothelialization. Taken together, icariin-loaded β-cyclodextrin sulfate can achieve anticoagulation and rapid endothelialization of TEBVs to ensure their long-term patency. | Jingyuan Yang Keyu Wei Yeqin Wang Yanzhao Li Ning Ding Da Huo Tianran Wang Guanyuan Yang Mingcan Yang Tan Ju Wen Zeng Chuhong Zhu | 2018 | Science China(Life Sciences)2018，61，10： | 5 |
| 2 | CCR10 and its ligands in regulation of epithelial immunity and diseases显示文摘Epithelial tissues covering the external and internal surface of a body are constantly under physical,chemical or biological assaults.To protect the epithelial tissues and maintain their homeostasis,multiple layers of immune defense mechanisms are required.Besides the epithelial tissue-resident immune cells that provide the first line of defense,circulating immune cells are also recruited into the local tissues in response to challenges.Chemokines and chemokine receptors regulate tissue-specific migration,maintenance and functions of immune cells.Among them,chemokine receptor CCR10 and its ligands chemokines CCL27 and CCL28 are uniquely involved in the epithelial immunity.CCL27 is expressed predominantly in the skin by keratinocytes while CCL28 is expressed by epithelial cells of various mucosal tissues.CCR10 is expressed by various subsets of innate-like T cells that are programmed to localize to the skin during their developmental processes in the thymus.Circulating T cells might be imprinted by skin-associated antigen-presenting cells to express CCR10 for their recruitment to the skin during the local immune response.On the other hand,IgA antibody-producing B cells generated in mucosa-associated lymphoid tissues express CCR10 for their migration and maintenance at mucosal sites.Increasing evidence also found that CCR10/ligands are involved in regulation of other immune cells in epithelial immunity and are frequently exploited by epithelium-localizing or-originated cancer cells for their survival,proliferation and evasion from immune surveillance.Herein,we review current knowledge on roles of CCR10/ligands in regulation of epithelial immunity and diseases and speculate on related important questions worth further investigation. | Na Xiong Yaoyao Fu Shaomin Hu Mingcan Xia Jie Yang | 2012 | Protein & Cell2012，3，8： | 5 |
| 3 | Nickel and indium core-shell co-catalysts loaded silicon nanowire arrays for efficient photoelectrocatalytic reduction of CO_(2) to formate显示文摘Developing an efficient artificial photosynthetic system for transforming carbon dioxide and storing solar energy in the form of chemical bonds is one of the greatest challenges in modern chemistry.However,the limited choice of catalysts with wide light absorption range,long-term stability and excellent selectivity for CO_(2) reduction makes the process sluggish.Here,a core-shell-structured nonnoble-metal Ni@In co-catalyst loaded p-type silicon nanowire arrays(SiNWs)for efficient CO_(2) reduction to formate is demonstrated.The formation rate and Faradaic efficiency of formate over the Ni@In/SiNWs catalyst reach 58μmol h^(-1) cm^(-2) and 87% under the irradiation of one simulated sunlight(AM 1.5 G,100 mW cm^(-2)),respectively,which are about 24 and 12 times those over the pristine SiNWs.The enhanced photoelectrocatalytic performance for CO_(2) reduction is attributed to the rational combination of Ni capable of effectively extracting the photogenerated electrons and In responsible for the selective activation of CO_(2). | Wenchao Ma Mingcan Xie Shunji Xie Longfu Wei Yichen Cai Qinghong Zhang Ye Wang | 2021 | Journal of Energy Chemistry2021，30，3： | 3 |
| 4 | Engineering hiPSC-CM and hiPSC-EC laden 3D nanofibrous splenic hydrogel for improving cardiac function through revascularization and remuscularization in infarcted heart显示文摘Cell therapy has been a promising strategy for cardiac repair after myocardial infarction(MI),but a poor ischemic environment and low cell delivery efficiency remain significant challenges.The spleen serves as a hematopoietic stem cell niche and secretes cardioprotective factors after MI,but it is unclear whether it could be used for human pluripotent stem cell(hiPSC)cultivation and provide a proper microenvironment for cell grafts against the ischemic environment.Herein,we developed a splenic extracellular matrix derived thermoresponsive hydrogel(SpGel).Proteomics analysis indicated that SpGel is enriched with proteins known to modulate the Wnt signaling pathway,cell-substrate adhesion,cardiac muscle contraction and oxidation-reduction processes.In vitro studies demonstrated that hiPSCs could be efficiently induced into endothelial cells(iECs)and cardiomyocytes(iCMs)with enhanced function on SpGel.The cytoprotective effect of SpGel on iECs/iCMs against oxidative stress damage was also proven.Furthermore,in vivo studies revealed that iEC/iCM-laden SpGel improved cardiac function and inhibited cardiac fibrosis of infarcted hearts by improving cell survival,revascularization and remuscularization.In conclusion,we successfully established a novel platform for the efficient generation and delivery of autologous cell grafts,which could be a promising clinical therapeutic strategy for cardiac repair and regeneration after MI. | Ge Guan Da Huo Yanzhao Li Xiaolin Zhao Yinghao Li Zhongliang Qin Dayu Sun Guanyuan Yang Mingcan Yang Ju Tan Wen Zeng Chuhong Zhu | 2021 | Bioactive Materials2021，6，12： | 2 |
| 5 | The promotion of endothelial progenitor cells recruitment by nerve growth factors in tissue-engineered blood vessels显示文摘 | Wen Zeng Wei Yuan Li Li Jianhong Mi Shangcheng Xu Can Wen Zhenhua Zhou Jiaqiang xiong Jiansen Sun Dajun Ying Mingcan Yang Xiaosong Li Chuhong Zhu | 2009 | Biomaterials2009，，7： | 1 |
| 6 | Significant diethyl phthalate de gradation by combined advanced oxidation process in aqueous solution显示文摘 | Seungmin Na Yun-Gyong Ahn Mingcan Cui | 2012 | Journal of Environmental Management2012，101，： | 1 |
| 7 | Sonophotolytic diethyl phthalate(DEP)degradation with UVC or VUV irradiation显示文摘 | Seungmin Na Cai Jinhua Mingcan Cui | 2012 | Ultrasonics Sonochemistry2012，19，5： | 1 |
| 8 | A continuous pilot-scale system using coal-mine drainage sludge to treat acid mine drainage contaminated with high concentrations of Pb, Zn, and other heavy metals显示文摘 | Mingcan Cui Min Jang Sang-Hyun Cho Jeehyeong Khim Fred S. Cannon | 2012 | Journal of Hazardous Materials2012，，： | 1 |
| 9 | Surface etching induced ultrathin sandwich structure realizing enhanced photocatalytic activity显示文摘Photocatalytic conversion efficiency is limited by serious charge carrier recombination. Efficient carrier separation is usually achieved by elegantly-designed multi-component structures connected by directional electric field. Herein, we developed a twodimensional(2 D) sandwich structure, as a new photocatalytic system, to realize high-efficiency carrier separation. This strategy integrated multifunction into a single structure for the first time, which successfully introduces a stable built-in electric field,realizing high-effective carrier separation. Besides, the carrier concentration is dramatically increased due to dimensional confinement. Benefiting from above synergic advantages, 2 D sandwich photocatalyst achieves the highest nitrogen fixation rate(435 μmol g^(-1) h^(-1)) in inorganic solid photocatalysts under visible light irradiation. We anticipate that 2 D sandwich photocatalyst holds promises for the application and expansion of 2 D materials in photocatalysis research. | Bo Yang Wentuan Bi Yangyang Wan Xiaogang Li Mingcan Huang Ruilin Yuan Huanxin Ju Wangsheng Chu Xiaojun Wu Linghui He Changzheng Wu Yi Xie | 2018 | Science China Chemistry2018，61，12： | 1 |
| 10 | Comparative analysis of the cardiac structure and transcriptome of scallop and snail,perspectives on heart chamber evolution显示文摘The evolution of a two-chambered heart,with an atrium and a ventricle,has improved heart function in both deuterostomes(vertebrates)and some protostomes(invertebrates).Although studies have examined the unique structure and function of these two chambers,molecular comparisons are few and limited to vertebrates.Here,we focus on the two-chambered protostome heart of the mollusks,offering data that may provide a better understanding of heart evolution.Specifically,we asked if the atrium and ventricle differ at the molecular level in the mollusk heart.To do so,we examined two very different species,the giant African land snail(Lissachatina fulica)and the relatively small,aquatic yesso scallop(Mizuhopecten yessoensis),with the assumption that if they exhibited commonality these similarities would likely reflect those across the phylum.We found that,although the hearts of these two species differed histologically,their cardiac gene function enrichments were similar,as revealed by transcriptomic analysis.Furthermore,the atrium and ventricle in each species had distinct gene function clusters,suggesting an evolutionary differentiation of cardiac chambers in mollusks.Finally,to explore the relationship between vertebrate and invertebrate two-chambered hearts,we compared our transcriptomic data with published data from the zebrafish,a well-studied vertebrate model with a two-chambered heart.Our analysis indicated a functional similarity of ventricular genes between the mollusks and the zebrafish,suggesting that the ventricle was differentiated to achieve the same functions in invertebrates and vertebrates.As the first such study on protostomes,our findings offered initial insights into how the two-chambered heart arose,including a possible understanding of its occurrence in both protostomes and deuterostomes. | Meina Lu Rabia Hayat Xuejiao Zhang Yaqi Jiao Jianyun Huang Yifan Huangfu Mingcan Jiang Jieyi Fu Qingqiu Jiang Yaojia Gu Shi Wang Alexander A.Akerberg Ying Su Long Zhao | 2023 | Marine Life Science & Technology2023，5，4： | 1 |
| 11 | A Continuous pilot-scale system using coal-mine drainage sludge to treat acid mine drainage con- taminated with high concentrations of Pb, Zn, and other heavy metals 显示文摘 | Cui Mingcan Jang Min Cho Sang-Hyun | 2012 | J Hazard Mater2012，，： | 1 |
| 12 | The Construction of Evaluation Indicator System for Low-carbon Village and Practice Research in Yuanjiang County显示文摘Low-carbon village is a new eco-development model in the context of low-carbon economy,the inevitable trend for achieving coordinated development between man and nature,and the inevitable choice for achieving sustainable development.This paper has built a low-carbon village evaluation system with 3 levels and 20 indicators.On this basis,taking Yuanjiang County as empirical research object,we use distance function model method to analyze and evaluate the low carbonization of village in Yuanjiang County,in order to provide a reference for the lowcarbon village evaluation. | Punan SHI Mingcan LUO | 2013 | Asian Agricultural Research2013，5，12： | 0 |
| 13 | Programmable dual responsive system reconstructing nerve interaction with small-diameter tissue-engineered vascular grafts and inhibiting intimal hyperplasia in diabetes显示文摘Small-diameter tissue-engineered vascular grafts(sdTEVGs)with hyperglycemia resistance have not been constructed.The intimal hyperplasia caused by hyperglycemia remains problem to hinder the patency of sdTEVGs.Here,inspired by bionic regulation of nerve on vascular,we found the released neural exosomes could inhibit the abnormal phenotype transformation of vascular smooth muscle cells(VSMCs).The transformation was a prime culprit causing the intimal hyperplasia of sdTEVGs.To address this concern,sdTEVGs were modified with an on-demand programmable dual-responsive system of ultrathin hydrogels.An external primary Reactive Oxygen Species(ROS)-responsive Netrin-1 system was initially triggered by local inflammation to induce nerve remolding of the sdTEVGs overcoming the difficulty of nerve regeneration under hyperglycemia.Then,the internal secondary ATP-responsive DENND1A(guanine nucleotide exchange factor)system was turned on by the neurotransmitter ATP from the immigrated nerve fibers to stimulate effective release of neural exosomes.The results showed nerve fibers grow into the sdTEVGs in diabetic rats 30 days after transplantation.At day 90,the abnormal VSMCs phenotype was not detected in the sdTEVGs,which maintained long-time patency without intima hyperplasia.Our study provides new insights to construct vascular grafts resisting hyperglycemia damage. | Yanzhao Li Yeqin Wang Fangchao Xue Xuli Feng Zhaojing Ba Junjie Chen Zhenhua Zhou Yanhong Wang Ge Guan Guanyuan Yang Ziwei Xi Hao Tian Yong Liu Ju Tan Gang Li Xiewan Chen Mingcan Yang Wen Chen Chuhong Zhu Wen Zeng | 2022 | Bioactive Materials2022，7，1： | 0 |
| 14 | Analysis of performance-based pay model of university financial officers显示文摘 | Mingcan Sun | 2013 | International Journal of Technology Management2013，，12： | 0 |
| 15 | Concentration fluctuation caused by reaction-diffusion coupling near catalytic active sites显示文摘The coupling of reaction and diffusion between neighboring active sites in the catalyst pore leads to the spatiotemporal fluctuation in component concentration,which is very importa nt to catalyst performance and hence its optimal design.Molecular dynamics simulation with hard-sphere and pseudo-particle modeling has previously revealed the non-stochastic concentration fluctuation of the reactant/product near isolated active site due to such coupling,using a simple model reaction of A→B in 2D pores.The topic is further developed in this work by studying the concentration fluctuation due to such coupling between neighboring active sites in 3D pores.Two 3D pore models containing an isolated active site and two adjacent active sites were constructed,respectively.For the isolated site,the concentration fluctuation intensifies for larger pores,but the product yield decreases,and for a given pore size,the product yield reaches a peak at a certain reactant concentration.For two neighboring sites,their distance(d)is found to have little effect on the reaction,but significant to the diffusion.For the same reaction competing at both sites,larger d leads to more efficient diffusion and better overall performance.However,for sequential reactions at the two sites,higher overall performance presents at a smaller d.The results should be helpful to the catalyst design and reaction control in the relevant processes. | Haolei Zhang Mingcan Zhao Yanping Li Chengxiang Li Wei Ge | 2022 | Chinese Journal of Chemical Engineering2022，，10： | 0 |
| 16 | Problems ,and improvement strategies in foundation work of college accounting显示文摘 | Mingcan Sun | 2013 | International Journal of Technology Management2013，，8： | 0 |
| 17 | Preclinical evaluation of the safety and effectiveness of a new bioartificial cornea显示文摘Cross-linking agents are frequently used to restore corneal properties after decellularization,and it is especially important to select an appropriate method to avoid excessive cross-linking.In addition,how to promote wound healing and how to improve scar formation require further investigation.To ensure the safety and efficacy of animal-derived products,we designed bioartificial corneas(BACs)according to the criteria for Class III medical devices.Our BACs do not require cross-linking agents and increase mechanical strength via self-cross-linking of aldehyde-modified hyaluronic acid(AHA)and carboxymethyl chitosan(CMC)on the surface of decellularized porcine corneas(DPCs).The results showed that the BACs had good biocompatibility and transparency,and the modification enhanced their antibacterial and anti-inflammatory properties in vitro.Preclinical animal studies showed that the BACs can rapidly regenerate the epithelium and restore vision within a month.After 3 months,the BACs were gradually filled with epithelial,stromal,and neuronal cells,and after 6 months,their transparency and histology were almost normal.In addition,side effects such as corneal neovascularization,conjunctival hyperemia,and ciliary body hyperemia rarely occur in vivo.Therefore,these BACs show promise for clinical application for the treatment of infectious corneal ulcers and as a temporary covering for corneal perforations to achieve the more time. | Yansha Hao Jingting Zhou Ju Tan Feng Xiang Zhongliang Qin Jun Yao Gang Li Mingcan Yang Lingqin Zeng Wen Zeng Chuhong Zhu | 2023 | Bioactive Materials2023，，11： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员