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| 1 | Nat Chem Biol:利用CRISPR-Cas9激活细菌中沉默的基因簇,有望发现新的药物显示文摘为了抵抗疾病,很多医药库中的武器是从细菌当中获得的。如今,利用CRISPR-Cas9基因编辑技术。研究人员揭示出沉默基因中隐藏着的更多潜在的宝藏。作为一类常见的细菌。链霉菌被用来产生很多作为抗生素、抗癌试剂和其他药物的化合物。在一项新的研究中。来自美国伊利诺伊大学和新加坡科技研究局的研究人员利用CRISPR-Cas9技术激活链霉菌中不表达的或者说沉默的基因簇。 | Mingzi M Zhang, Wan Lin Yeo, Ee Lui Ang, Huimin Zhao Fong Tian Wong, Elena Heng Yajie Wang, Shangwen Luo, Ryan E Cobb, Behnam Enghiad, Huimin Zhao Yee Hwee Lim | 2017 | 现代生物医学进展2017，17，17： | 12 |
| 2 | Enhanced pyrocatalysis of the pyroelectric BiFeO_(3)/g-C_(3)N_(4) heterostructure for dye decomposition driven by cold–hot temperature alternation显示文摘The BiFeO_(3)/g-C_(3)N_(4) heterostructure,which is fabricated via a simple mixing–calcining method,benefits the significant enhancement of the pyrocatalytic performance.With the growth of g-C_(3)N_(4) content in the heterostructure pyrocatalysts from 0 to 25%,the decomposition ratio of Rhodamine B(RhB)dye after 18 cold-hot temperature fluctuation(25-65℃)cycles increases at first and then decreases,reaching a maximum value of~94.2%at 10%while that of the pure BiFeO_(3) is~67.7%.The enhanced dye decomposition may be due to the generation of the internal electric field which strengthens the separation of the positive and negative carriers and further accelerates their migrations.The intermediate products in the pyrocatalytic reaction also have been detected and confirmed,which proves the key role of the pyroelectric effect in realizing the dye decomposition using BiFeO_(3)/g-C_(3)N_(4) heterostructure catalyst.The pyroelectric BiFeO_(3)/g-C_(3)N_(4) heterostructure shows the potential application in pyrocatalytically degrading dye wastewater. | Mingzi Chen Yanmin Jia Huamei Li Zheng Wu Tianyin Huang Hongfang Zhang | 2021 | Journal of Advanced Ceramics2021，10，2： | 6 |
| 3 | Differences of hormones involved in adipose metabolism and lactation between high and low producing Holstein cows during heat stress显示文摘The experiment was conducted to evaluate hormonal involvement in the adipose metabolism and lactation between high and low producing dairy cows in a hot environment. Forty Holstein healthy cows with a similar parity were used and assigned into high producing group(average production41.44 ± 2.25 kg/d) and low producing group(average production 29.92 ± 1.02 kg/d) with 20 cows in each group. Blood samples were collected from caudal vein to determine the difference of hormones related to adipose metabolism and lactation. The highest, lowest, and average temperature humidity index(THI),recorded as 84.02, 79.35 and 81.89, respectively, indicated that cows were at the state of high heat stress.No significant differences between high and low producing groups were observed in the levels of nonestesterified fatty acid(NEFA), β-hydroxy butyrate(β-OHB), total cholesterol(TCHO), and insulin(INS)(P > 0.05). However, the very low density lipoprotein(VLDL), apolipoprotein B100(apoB-100), highdensity lipoprotein(HDL-C) and estrogen(E2) concentrations in high producing group were significantly higher than those of low producing group(P < 0.05). No significant differences between high and low producing groups were observed in the levels of prolactin(PRL) and progesterone(PROG)(P > 0.05),whereas high producing group had a rise in the insulin-like growth factor-1(IGF-1) level compared with low producing group(P < 0.05). These results indicated that, during summer, high and low producing dairy cows have similar levels of lipid catabolism, but high producing dairy cows have advantages in outputting hepatic triglyceride(TG). | Mingzi Qu Shengjuan Wei Zhiqiang Chen Guangmeng Wang Yue Zheng Peishi Yan | 2015 | Animal Nutrition2015，，4： | 4 |
| 4 | Myocardin-related transcription factor A cooperates with brahmarelated gene 1 to activate P-selectin transcription显示文摘Expression of P-selectin in injured or activated endothelia cells serves as a permissive step towards leukocyte recruitment and perpetuation of inflammation in the pathogenesis of atherosclerosis.P-selectin can be induced by pro-inflammatory stimuli via the transcription factor NF-κB,but the epigenetic mechanisms remain incompletely understood.Previously we reported that myocardin-related transcription factor A(MRTF-A)mediates the transactivation of a slew of adhesion molecules by oxidized low-density lipoprotein(oxLDL),likely through a crosstalk with brahma-related gene 1(BRGl),a chromatin remodeling protein.Here,we show that MRTF-A was both sufficient and necessary for the transactivation of P-selectin gene in endothelial cells treated with TNF-α.Depletion of MRTF-A using small interfering RNA(siRNA)abrogated the binding of BRGl on the P-selectin promoter.Overexpression of BRG1 up-regulated the activity of P-selectin promoter activity while BRGl knockdown attenuated P-selectin expression.Finally,BRGl silencing suppressed the accumulation of acetylated histone H3 and methylated histone H3K4,and altered the binding of NF-κB on the P-selectin promoter.Therefore,our data demonstrate an essential role for MRTF-A and BRGl in P-selectin transactivation in endothelial cells. | Mingzi Song Mingming Fang Liming Yu Yong Xu | 2016 | The Journal of Biomedical Research2016，30，1： | 2 |
| 5 | Expression of CD147 and Lewis y antigen in ovarian cancer and their relationship to drug resistance显示文摘 | Jian Gao Zhenhua Hu Juanjuan Liu Dawo Liu Yanyan Wang Mingbo Cai Danye Zhang Mingzi Tan Bei Lin | 2014 | Medical Oncology2014，，5： | 2 |
| 6 | MOF-Transformed In_(2)O_(3-x)@C Nanocorn Electrocatalyst for Efficient CO_(2)Reduction to HCOOH显示文摘For electrochemical CO_(2) reduction to HCOOH,an ongoing challenge is to design energy efficient electrocatalysts that can deliver a high HCOOH current density(JHCOOH)at a low overpotential.Indium oxide is good HCOOH production catalyst but with low con-ductivity.In this work,we report a unique corn design of In_(2)O_(3-x)@C nanocatalyst,wherein In_(2)O_(3-x)nanocube as the fine grains dispersed uniformly on the carbon nanorod cob,resulting in the enhanced conductivity.Excellent performance is achieved with 84%Faradaic efficiency(FE)and 11 mA cm^(−2)JHCOOH at a low potential of−0.4 V versus RHE.At the current density of 100 mA cm^(−2),the applied potential remained stable for more than 120 h with the FE above 90%.Density functional theory calculations reveal that the abundant oxygen vacancy in In_(2)O_(3-x) has exposed more In^(3+) sites with activated electroactivity,which facilitates the formation of HCOO*intermediate.Operando X-ray absorp-tion spectroscopy also confirms In^(3+) as the active site and the key intermediate of HCOO*during the process of CO_(2) reduction to HCOOH. | Chen Qiu Kun Qian Jun Yu Mingzi Sun Shoufu Cao Jinqiang Gao Rongxing Yu Lingzhe Fang Youwei Yao Xiaoqing Lu Tao Li Bolong Huang Shihe Yang | 2022 | Nano-Micro Letters2022，14，10： | 2 |
| 7 | Mechanical properties and influence mechanism of confined concrete arches in high-stress tunnels显示文摘Deep underground projects(e.g., coal mines), are often faced with complex conditions such as high stress and extremely soft rock. The strength and rigidity of the traditional support system are often insufficient,which makes it difficult to meet the requirements of ground control under complex conditions. As a new support form with high strength and rigidity, the confined concrete arch plays an important role in controlling the rock deformation under complex conditions. The section shape of the tunnel has an important impact on the mechanical properties and design of the support system. However, studies on the mechanical properties and influence mechanism of the new confined concrete arch are rarely reported. To this end, the mechanical properties of traditional U-shaped steel and new confined concrete arches are compared and comparative tests on arches of circular and straight-leg semicircular shapes in deep tunnels are conducted. A large mechanical testing system for underground engineering support structure is developed. The mechanical properties and influence mechanism of confined concrete arches with different section shapes under different loading modes and cross-section parameters are systematically studied. Test results show that the bearing capacity of the confined concrete arch is 2.10 times that of the U-shaped steel arch, and the bearing capacity of the circular confined concrete arch is 2.27 times that of the straight-leg semicircular arch. Among the various influencing factors and their engineering parameters,the lateral stress coefficient has the greatest impact on the bearing capacity of the confined concrete arch,followed by the steel pipe wall thickness, steel strength, and core concrete strength. Subsequently, the economic index of bearing capacity and cost is established, and the optimization design method for the confined concrete arch is proposed. Finally, this design method is applied to a high-stress tunnel under complex conditions, and the deformation of the surrounding rock is effectively controlled. | Bei Jiang Zhongxin Xin Xiufeng Zhang Yusong Deng Mingzi Wang Shidong Li Wentao Ren | 2023 | International Journal of Mining Science and Technology2023，33，7： | 2 |
| 8 | Patients having haemodialysis:physical activity and associated factors显示文摘 | Li Mingzi Li liping Fan xiaozhi | 2010 | J Adv Nurs2010，66，6： | 1 |
| 9 | Study of the physicochemical properties of silica powder and the stability of organic-inorganic hybrid emulsion in the presence of ethanol显示文摘 | Wen Xiufang Li Mingzi Pi Pihui | 2008 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2008，327，1315： | 1 |
| 10 | Epidemiology and clinical characteristics of burns in China's Mainland from 2009 to 2018显示文摘Background:Burn injuries place a heavy burden on the global healthcare system.However,there is still a lack of nationwide studies on the epidemiological characteristics of burn patients in China's Mainland.The present study aims to accurately analyze the clinical characteristics of burn patients by collecting data in China's Mainland from 2009 to 2018,which will provide effective strategies for healthcare systems and the government in China's Mainland.Methods:Patients admitted for burn injuries to 196 hospitals in 31 provinces,autonomous regions and municipalities in China's Mainland from 2009 to 2018 were included.The data collected included sex,age,month distribution,etiology,region,clinical outcome,injury anatomical location,total burn surface area and mortality.SPSS 19.0 software was used to analyze the data.Results:From 2009 to 2018,the burn patients were 333,995(0.76%),which included 222,480(66.61%)males and 111,515(33.39%)females.From 2009 to 2018,the number of individuals admit-ted to hospitals for burns showed a downward trend year by year.The burn patients accounted for the highest proportion of inpatients in 0-10 years(38.10%),followed by 40-50 years(13.14%).The highest cure ratio of burn inpatients was in the 20-30 age group(31394,71.53%).Among 31 provinces,autonomous regions and municipalities,the province with the highest proportion of total inpatients caused by burns was Inner Mongolia(4.61%),followed by Zhejiang(3.17%),Hainan(2.88%)and Xinjiang(2.64%).Summer(29.16%)was the season with the highest incidence of burn patients admitted to hospitals,followed by spring(25.6%).Scalding(60.19%)was the most frequent kind of burn treated,followed by fire(20.45%).The patients had multiple burn sites(68.89%)most often,followed by burns on the lower limbs(10.91%).From 0%to 10%total body surface area(TBSA)accounted for the highest ratio(37.19%),followed by 90-100%TBSA(21.74%).Conclusions:The present study is the first to describe the associated situation and trends of burn patients in China's Mainland from 2009 to 2018.Our findings will serve as the latest clinical evidence for healthcare planning and prevention efforts in China and other countries. | Jie Yang Guanglei Tian Jianchao Liu Huajuan Bai Shuxu Yang Mingzi Ran Hongyu Li Kui Ma Siming Yang Xiaobing Fu | 2022 | Burns & Trauma2022，10，1： | 1 |
| 11 | Preparation, character- ization and in vivo investigation of blood compatible hemoglobin loaded nanoparticles as Oxygen carriers显示文摘 | Lu Mingzi Zhao Caiyan Wang Quan | 2015 | Colloids and Surfaces B Biointerfaces2015，139，12： | 1 |
| 12 | Ginsenoside Rh3 induces pyroptosis and ferroptosis through the Stat3/p53/NRF2 axis in colorectal cancer cells显示文摘Ginsenoside Rh3(GRh3)is a seminatural product obtained by chemical processing after isolation from Chinese herbal medicine that has strong antitumor activity against human tumors.However,its antitumor role remains to be elucidated.The aim of this study is to explore the mechanisms underlying the tumor suppressive activity of GRh3 from the perspective of pyroptosis and ferroptosis.GRh3 eliminates colorectal cancer(CRC)cells by activating gasdermin D(GSDMD)-dependent pyroptosis and suppressing solute carrier family 7 member 11(SLC7A11),resulting in ferroptosis activation through the Stat3/p53/NRF2 axis.GRh3 suppresses nuclear factor erythroid 2-related factor 2(NRF2)entry into the nucleus,leading to the decrease of heme oxygenase 1(HO-1)expression,which in turn promotes NOD-like receptor thermal protein domain associated protein 3(NLRP3)and caspase-1 expression.Finally,caspase-1 activates GSDMD-dependent pyroptosis.Furthermore,GRh3 prevents NRF2 from entering the nucleus,which suppresses SLC7A11,causing the depletion of glutathione(GSH)and accumulation of iron,lipid reactive oxygen species(ROS)and malondialdehyde(MDA),and eventually leading to ferroptosis in CRC cells.In addition,GRh3 effectively inhibits the proliferation of CRC cells in vitro and in nude mouse models.Collectively,GRh3 triggers pyroptotic cell death and ferroptotic cell death in CRC cells via the Stat3/p53/NRF2 axis with minimal harm to normal cells,showing great anticancer potential. | Yingchao Wu Dajin Pi Shuyao Zhou Zhongjia Yi Yangyang Dong Wuhong Wang Huan Ye Yiliu Chen Qian Zuo Mingzi Ouyang | 2023 | Acta Biochimica et Biophysica Sinica2023，55，4： | 1 |
| 13 | Strain modulation of phase transformation of noble metal nanomaterials显示文摘Noble metals have been extensively studied owing to their high chemical stability and outstanding catalytic properties in various important reactions.However,their large-scale application of noble metals is still challenged by their high expense and scarcity on the earth,as well as the yet insufficient activity to give a satisfying performance.For decades,enormous research efforts have been devoted to the nanoengineering of noble metal nanocrystals,such as the size-,composition-,shape-,and/or morphology-controlled syntheses,and impressive advances have been achieved.Meanwhile,the discovery that the crystal structure of noble metal nanocrystals also has a significant impact on their properties opened a new pathway that modulates the crystal phases of noble metals to achieve better properties.Among the feasible methods for crystal phase transformation,the presence of strain is not negligible.Strain generally has two roles:the driving force of the phase transformation and/or the origin of the distinct properties of the new crystal structure.Strain effect on noble metals has also been extensively studied due to its capability of fine-tuning the surface catalytic activity.Therefore,combining the two hot research trends together,a possible research pathway is emerging.That is,utilizing the potential synergistic effect between novel crystal phases and the subsequent lattice strain to boost the performance of noble metal nanocrystal even further.Herein,a brief summary of the currently discovered noble metal phases and strain effect and the introduction of strain related phase modulation techniques along with the catalytic applications will be presented.Finally,a brief conclusion and future perspective is given. | Tong Wu Mingzi Sun Bolong Huang | 2020 | InfoMat2020，2，4： | 1 |
| 14 | Expression of CD147 and Lewis y antigen in ovarian cancer and their relationship to drug resistance显示文摘 | Jian Gao Zhenhua Hu Juanjuan Liu Dawo Liu Yanyan Wang Mingbo Cai Danye Zhang Mingzi Tan Bei Lin | 2014 | Medical Oncology2014，，5： | 1 |
| 15 | Segmented Au/PtCo heterojunction nanowires for efficient formic acid oxidation catalysis显示文摘Exploring a new strategy for the removal of adsorbed CO (CO^(*)) on a Pt surface at a low potential is the key to achieving enhanced catalysis for the formic acid oxidation reaction (FAOR);however, the development of such a strategy remains a significant challenge. Herein, we report a class of Au/PtCo heterojunction nanowires (HNWs) as efficient electrocatalysts for accelerating the FAOR. This heterojunction structure and the induced Co alloying effects can facilitate formic acid adsorption/activation on Pt with high CO tolerance, generating the FAOR pathway from dehydration to dehydrogenation. The optimized Au_(23)/Pt_(63)Co_(14) HNWs showed the highest specific and mass activities of 11.7 mA cm^(−2)Pt and 6.42 A mg^(−1)Pt reported to date, respectively, which are considerably higher than those of commercial Pt/C. DFT calculations confirmed that the electron-rich Au segment enhances the electronic activity of the PtCo NWs, which not only allows the construction of a highly efficient electron transfer channel for the FAOR but also suppresses CO formation. | Yingjun Sun Bolong Huang Yingjie Li Yingnan Qin Ziqi Fu Mingzi Sun Lei Wang Shaojun Guo | 2021 | Fundamental Research2021，1，4： | 1 |
| 16 | Activationofepidermalgrowthfactorreceptormediatesreperfusionarrhythmiasinanaes-thetizedrats显示文摘 | FengM XiangJZ MingZY etal | 2012 | CardiovascRes2012，93，1： | 1 |
| 17 | Interface synergistic effects induced multi-mode luminescence显示文摘Mechanoluminescence(ML)has become the most promising material for broad applications in display and sensing devices,in which ZnS is the most commonly studied one due to its stable and highly repetitive ML performances.In this work,we have successfully prepared the biphase ZnS on a large scale through the facile in-air molten salt protection strategy.The obtained biphase has the best ML properties,which is mainly attributed to the synergistic effects of piezo-photonic,defect,and interface dislocations.DFT calculations have confirmed that the defects activate the local S and Zn sites and reduce the energy barrier for electron transfer.The much stronger X-ray induced luminescence than the commercial scintillator is also reached.The application of ZnS particles in both papers and inks delivers superior performance.Meanwhile,ZnS particles based screen printing ink is able to directly print on paper,plastic and other carriers to form clear marks.These proposed paper and ink hold great potentials in applications of information security and anti-counterfeiting based on the multi-mode luminescence properties.This work provides a new avenue to understand and realize the high-performance multi-mode luminescence,inspiring more future works to extend on other ML materials and boosting their practical applications. | Ronghua Ma Chunfeng Wang Wei Yan Mingzi Sun Jianxiong Zhao Yuantian Zheng Xu Li Longbiao Huang Bing Chen Feng Wang Bolong Huang Dengfeng Peng | 2022 | Nano Research2022，15，5： | 1 |
| 18 | Model Reference Adaptive Control-Based Speed Control of Brushless DC Motors With Low-Reso- lution Hall-Effect Sensors 显示文摘 | Yang Liu Jin Zhao Mingzi Xia | 2014 | IEEE Transactions on Power Elec- tronics2014，29，3： | 1 |
| 19 | Ultrastable bimetallic Fe_(2)Mo for efficient oxygen reduction reaction in pH-universal applications显示文摘Iron-based nanostructures represent an emerging class of catalysts with high electroactivity for oxygen reduction reaction(ORR)in energy storage and conversion technologies.However,current practical applications have been limited by insufficient durability in both alkaline and acidic environments.In particular,limited attention has been paid to stabilizing iron-based catalysts by introducing additional metal by the alloying effect.Herein,we report bimetallic Fe_(2)Mo nanoparticles on N-doped carbon(Fe_(2)Mo/NC)as an efficient and ultra-stable ORR electrocatalyst for the first time.The Fe_(2)Mo/NC catalyst shows high selectivity for a four-electron pathway of ORR and remarkable electrocatalytic activity with high kinetics current density and half-wave potential as well as low Tafel slope in both acidic and alkaline medias.It demonstrates excellent long-term durability with no activity loss even after 10,000 potential cycles.Density functional theory(DFT)calculations have confirmed the modulated electronic structure of formed Fe_(2)Mo,which supports the electron-rich structure for the ORR process.Meanwhile,the mutual protection between Fe and Mo sites guarantees efficient electron transfer and long-term stability,especially under the alkaline environment.This work has supplied an effective strategy to solve the dilemma between high electroactivity and long-term durability for the Fe-based electrocatalysts,which opens a new direction of developing novel electrocatalyst systems for future research. | Jue Hu Chengxu Zhang Mingzi Sun Qianglong Qi Shanxiong Luo Hongchuan Song Jingyi Xiao Bolong Huang Michael K.H.Leung Yingjie Zhang | 2022 | Nano Research2022，15，6： | 1 |
| 20 | Novel Real-Time System for Traffic Flow Classification and Prediction显示文摘Traffic flow prediction has been applied into many wireless communication applications(e.g., smart city, Internet of Things). With the development of wireless communication technologies and artificial intelligence, how to design a system for real-time traffic flow prediction and receive high accuracy of prediction are urgent problems for both researchers and equipment suppliers. This paper presents a novel real-time system for traffic flow prediction. Different from the single algorithm for traffic flow prediction, our novel system firstly utilizes dynamic time wrapping to judge whether traffic flow data has regularity,realizing traffic flow data classification. After traffic flow data classification, we respectively make use of XGBoost and wavelet transform-echo state network to predict traffic flow data according to their regularity. Moreover, in order to realize real-time classification and prediction, we apply Spark/Hadoop computing platform to process large amounts of traffic data. Numerical results show that the proposed novel system has better performance and higher accuracy than other schemes. | YE Dezhong LV Haibing GAO Yun BAO Qiuxia CHEN Mingzi | 2019 | ZTE Communications2019，17，2： | 0 |
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