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| 1 | Microbiota alterations in acute and chronic gastrointestinal inflammation of cats and dogs显示文摘The intestinal microbiota is the collection of the living microorganisms(bacteria, fungi, protozoa, and viruses) inhabiting the gastrointestinal tract. Novel bacterial identification approaches have revealed that the gastrointestinal microbiota of dogs and cats is, similarly to humans, a highly complex ecosystem. Studies in dogs and cats have demonstrated that acute and chronic gastrointestinal diseases, including inflammatory bowel disease(IBD), are associated with alterations in the small intestinal and fecal microbial communities. Of interest is that these alterations are generally similar to the dysbiosis observed in humans with IBD or animal models of intestinal inflammation, suggesting that microbial responses to inflammatory conditions of the gut are conserved across mammalian host types. Studies have also revealed possible underlying susceptibilities in the innate immune system of dogs and cats with IBD, which further demonstrate the intricate relationship between gut microbiota and host health. Commonly identified microbiome changes in IBD are decreases in bacterial groups within the phyla Firmicutes and Bacteroidetes, and increases within Proteobacteia. Furthermore, a reduction in the diversity of Clostridium clusters XIVa and IV(i.e., Lachnospiraceae and Clostridium coccoides subgroups) are associated with IBD, suggesting that these bacterial groups may play an important role in maintenance of gastrointestinal health. Future studies are warranted to evaluate the functional changes associated with intestinal dysbiosis in dogs and cats. | Julia B Honneffer Yasushi Minamoto Jan S Suchodolski | 2014 | World Journal of Gastroenterology2014，20，44： | 6 |
| 2 | Effect of gemcitabine on the expression of apoptosis-related genes in human pancreatic cancer cells显示文摘瞄准:为了调查基因的表示,在人的胰腺的癌症房间在导致 gemcitabine 的细胞毒性包含了。方法:一根人的胰腺的癌症房间线, PANC-1,是有教养的。1x10 (4 ) PANC-1 房间是在 96 井的 plated 微效价盘子。在为 24 h 被孵化以后, gemcitabine 在集中变化 2.5-1000 mg/L 被加到媒介。AlamarBlue 染料方法被用于细胞生长分析。DNA 破碎是用 DNA 破碎的份量上 assayed 连接酶的免疫吸着剂试金(ELISA ) 工具包。奶头和 TP53INP1 mRNA 表示与半量的分析用反向的抄写聚合酶链反应被决定。GSK-3beta 和 phospho-GSK-3beta 蛋白质的表示与西方的污点分析被检验。结果:为在到 gemcitabine 的 48-h 暴露以后的药的 IC50 是 16 mg/L。PANC-1 房间的生长被 gemcitabine 以一种集中依赖者方式(P<0.0001 ) 禁止,房间生长也在整个时间功课(P<0.0001 ) 被禁止。在在 48 h 的对待 gemcitabine 的组的 DNA 破碎率是 44.7% ,而它在未经治疗的组是 25.3% 。奶头 mRNA 表示在与 gemcitabine 被对待以后被减少,而 TP53INP1 mRNA 被 gemcitabine 处理增加。西方的污点分析证明 phospho- GSK-3beta (ser9 ) 被 gemcitabine 处理导致。结论:Gemcitabine 压制 PANC-1 房间增长并且导致 apoptosis。Apoptosis 被认为与抑制被联系奶头和 GSK-3beta,和 TP53INP1 和 pospho-GSK-3beta (ser9 ) 的激活。 | Pei-Hong Jiang Yoshiharu Motoo Norio Sawabu Toshinari Minamoto | 2006 | World Journal of Gastroenterology2006，12，10： | 3 |
| 3 | Phylogenetic relationship among Osmerid and Salangid fish inferred from mitochondrial cytochrome b gene sequences显示文摘 | Minamoto T Shimizu I | 2002 | Mere Fae Sci Kyoto Univ2002，18，： | 1 |
| 4 | Detection of cyprinid herpesvirus 3 DNA in river water during and after an outbreak 显示文摘 | MINAMOTO T HONJO M N UCHII K | 2009 | Vet Microbiol2009，135，34： | 1 |
| 5 | Viscoplastic effects occurring in impacts of aluminum and steel bodies and their influence on the coefficient of restitution显示文摘 | Seifried R Minamoto H Eberhard P | 2010 | Journal of Applied Mechanics2010，77，4： | 1 |
| 6 | Recipient iNOS but not eNOS deficiency reduces luminal narrowing in tracheal allografts 显示文摘 | Minamoto K Pinsky DJ | 2002 | J Exp Med2002，196，10： | 1 |
| 7 | Effect of FK-506 aministered of the corneal immune reaction in rats 显示文摘 | Okadak K Sakata H Minamoto A | 1996 | Ophthalmologica1996，210，： | 1 |
| 8 | Subglottic and mediastinal hemangioma in a child:treatment with propranolol显示文摘 | Tamagno M Bibas BJ Minamoto H | | 0，，3： | 1 |
| 9 | Multiple amino acids in the glycoprotein of rabies virus are responsible for pathogenicity in adult mice显示文摘 | Takayama-Ito M Ito N Yamada K Minamoto N | 2006 | Virus Res2006，115，2： | 1 |
| 10 | Endosonographic evaluation of c-kit-positive gastrointestinal stromal tumor显示文摘 | Okai T Minamoto T ohtsubo K | 2003 | Abdow Lmaging2003，28，3： | 1 |
| 11 | Characteristicsand surgical outcomes of pediatric retinal detachment显示文摘 | Yokoyama T KatoT Minamoto A | 2004 | Eye(Lond)2004，18，9： | 1 |
| 12 | Pars plana vitectomy for traumatic cyclodialysis with persistent hypotony 显示文摘 | Ishida Y Minamoto A Takamastsu M | 2004 | Eye2004，18，9： | 1 |
| 13 | Involvement of nucleoprotein,phosphoprotein,and matrix protein genes of rabies virus in virulence for adult mice显示文摘 | Shimizu K Ito N Mita T Yamada K Hosokawa-Muto J Sugiyama M Minamoto N | 2007 | Virus Res2007，123，2： | 1 |
| 14 | Determination of epidemiology of clinically isolated Cryptococcus neoformans strains in Japan by multilocus sequence typing显示文摘 | Umeyama T Ohno H Minamoto F | 2013 | Jpn J Infect Dis2013，66，1： | 1 |
| 15 | Therapy for fungal infections in leukemia 显示文摘 | Segal RE Minamoto GY | 2001 | Curr Oneol Rep2001，3，3： | 1 |
| 16 | Structure and function of a new STAT-induced STAT inhibitor显示文摘 | Naka T Narazaki M Hirata M Matsumoto T Minamoto S Aono A | 1997 | Nature1997，387，5636： | 1 |
| 17 | A virusneutralizing epitope on the glycoprotein of Rabies virus that contains Trp251 is a linear epitope显示文摘 | LUO T R MINAMOTO N ITO H | 1997 | Virus Res1997，51，1： | 1 |
| 18 | Suppression of corneal graft rejection by subcon junctival injection of FK-506 in a rat model of penetrating keratoplasty显示文摘 | Minamoto A Sakata H Okada K Fujihara M | 1995 | Jpn J Ophthalmol1995，39，1： | 1 |
| 19 | Antigenic and functional analyses of glycoprotein of rabies virus using monoclonal antibodies显示文摘 | Luo TR Minamoto N Hishida M | 1998 | Microbiol Immunol1998，42，3： | 1 |
| 20 | Thoracoscopy in children and adolescents 显示文摘 | de Gmpos JR Andrade Filho LO Werebe EC Minamoto H Quim AO Filomeno LT | 1997 | Chest1997，111，2： | 1 |
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