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| 1 | Body-mass index correlates with severity and mortality in acute pancreatitis: A meta-analysis显示文摘BACKGROUND Obesity rates have increased sharply in recent decades. As there is a growing number of cases in which acute pancreatitis(AP) is accompanied by obesity, we found it clinically relevant to investigate how body-mass index(BMI) affects the outcome of the disease.AIM To quantify the association between subgroups of BMI and the severity and mortality of AP.METHODS A meta-analysis was performed using the Preferred Reporting Items for Systematic Review and Meta-Analysis(PRISMA) Protocols. Three databases(PubMed, EMBASE and the Cochrane Library) were searched for articles containing data on BMI, disease severity and mortality rate for AP. Englishlanguage studies from inception to 19 June 2017 were checked against our predetermined eligibility criteria. The included articles reported all AP cases with no restriction on the etiology of the disease. Only studies that classified AP cases according to the Atlanta Criteria were involved in the severity analyses. Odds ratios(OR) and mean differences(MD) were pooled using the random effects model with the DerSimonian-Laird estimation and displayed on forest plots. The meta-analysis was registered in PROSPERO under number CRD42017077890.RESULTS A total of 19 articles were included in our meta-analysis containing data on 9997 patients. As regards severity, a subgroup analysis showed a direct association between AP severity and BMI. BMI < 18.5 had no significant effect on severity;however, BMI > 25 had an almost three-fold increased risk for severe AP in comparison to normal BMI(OR = 2.87, 95%CI: 1.90-4.35, P < 0.001). Importantly,the mean BMI of patients with severe AP is higher than that of the non-severe group(MD = 1.79, 95%CI: 0.89-2.70, P < 0.001). As regards mortality, death rates among AP patients are the highest in the underweight and obese subgroups. A BMI < 18.5 carries an almost two-fold increase in risk of mortality compared to normal BMI(OR = 1.82, 95%CI: 1.32-2.50, P < 0.001). However, the chance of mortality is almost equal in the normal BMI and BMI 25-30 subgroups. A BMI >30 results in a three times higher risk of mortality in comparison to a BMI < 30(OR = 2.89, 95%CI: 1.10-7.36, P = 0.026).CONCLUSION Our findings confirm that a BMI above 25 increases the risk of severe AP, while a BMI > 30 raises the risk of mortality. A BMI < 18.5 carries an almost two times higher risk of mortality in AP. | Dalma Dobszai Péter Mátrai Zoltan Gyongyi Dezso Csupor Judit Bajor Balint Eross Alexandra Mikó Lajos Szakó Agnes Meczker Roland Hágendorn Katalin Márta Andrea Szentesi Péter Hegyi on behalf of the Hungarian Pancreatic Study Group | 2019 | World Journal of Gastroenterology2019，25，6： | 11 |
| 2 | Restoration of energy level in the early phase of acute pediatric pancreatitis显示文摘Acute pancreatitis (AP) is a serious inflammatory disease with rising incidence both in the adult and pediatric populations. It has been shown that mitochondrial injury and energy depletion are the earliest intracellular events in the early phase of AP. Moreover, it has been revealed that restoration of intracellular ATP level restores cellular functions and defends the cells from death. We have recently shown in a systematic review and meta-analysis that early enteral feeding is beneficial in adults; however, no reviews are available concerning the effect of early enteral feeding in pediatric AP. In this minireview, our aim was to systematically analyse the literature on the treatmentof acute pediatric pancreatitis. The preferred reporting items for systematic review(PRISMA-P) were followed, and the question was drafted based on participants, intervention, comparison and outcomes: P: patients under the age of twenty-one suffering from acute pancreatitis; I: early enteral nutrition (per os and nasogastric- or nasojejunal tube started within 48 h); C: nil per os therapy; O: length of hospitalization, need for treatment at an intensive care unit, development of severe AP, lung injury (including lung oedema and pleural effusion), white blood cell count and pain score on admission. Altogether, 632 articles (Pub Med: 131; EMBASE: 501) were found. After detailed screening of eligible papers, five of them met inclusion criteria. Only retrospective clinical trials were available. Due to insufficient information from the authors, it was only possible to address length of hospitalization as an outcome of the study. Our mini-meta-analysis showed that early enteral nutrition significantly(SD = 0.806, P = 0.034) decreases length of hospitalization compared with nil per os diet in acute pediatric pancreatitis. In this minireview, we clearly show that early enteral nutrition, started within 24-48 h, is beneficial in acute pediatric pancreatitis. Prospective studies and better presentation of research are crucially needed to achieve a higher level of evidence. | Dóra Mosztbacher Nelli Farkas Margit Solymár Gabriella Pár Judit Bajor ákos Szucs József Czimmer Katalin Márta Alexandra Mikó Zoltán Rumbus Péter Varjú Péter Hegyi Andrea Párniczky | 2017 | World Journal of Gastroenterology2017，23，6： | 8 |
| 3 | Intralesional steroid is beneficial in benign refractory esophageal strictures:A meta-analysis显示文摘AIM To analyze the effect of intralesional steroid injections in addition to endoscopic dilation of benign refractory esophageal strictures.METHODS A comprehensive search was performed in three databases from inception to 10 April 2017 to identify trials, comparing the efficacy of endoscopic dilation to dilation combined with intralesional steroid injections. Following the data extraction, meta-analytical calculations were performed on measures of outcome by the randomeffects method of Der Simonian and Laird. Heterogeneity of the studies was tested by Cochrane's Q and I^2 statistics. Risk of quality and bias was assessed by the Newcastle Ottawa Scale and JADAD assessment tools.RESULTS Eleven articles were identified suitable for analyses, involving 343 patients, 235 cases and 229 controls in total. Four studies used crossover design with 121 subjects enrolled. The periodic dilation index(PDI) was comparable in 4 studies, where the pooled result showed a significant improvement of PDI in the steroid group(MD:-1.12 dilation/month, 95% CI:-1.99 to -0.25 P = 0.012; I^2 = 74.4%). The total number of repeat dilations(TNRD) was comparable in 5 studies and showed a non-significant decrease(MD:-1.17, 95%CI:-0.24-0.05, P = 0.057; I^2 = 0), while the dysphagia score(DS) was comparable in 5 studies and did not improve(SMD: 0.35, 95%CI:-0.38, 1.08, P = 0.351; I^2 = 83.98%) after intralesional steroid injection.CONCLUSION Intralesional steroid injection increases the time between endoscopic dilations of benign refractory esophageal strictures. However, its potential role needs further research. | László Szapáry Benedek Tinusz Nelli Farkas Katalin Márta Lajos Szakó Agnes Meczker Roland Hágendorn Judit Bajor Aron Vincze Zoltan Gyongyi Alexandra Mikó Dezso Csupor Péter Hegyi Balint Eross | 2018 | World Journal of Gastroenterology2018，24，21： | 7 |
| 4 | Chronic kidney disease severely deteriorates the outcome of gastrointestinal bleeding: A meta-analysis显示文摘AIM To understand the influence of chronic kidney disease(CKD) on mortality, need for transfusion and rebleeding in gastrointestinal(GI) bleeding patients.METHODS A systematic search was conducted in three databases for studies on GI bleeding patients with CKD or endstage renal disease(ESRD) with data on outcomes of mortality, transfusion requirement, rebleeding rate and length of hospitalization(LOH). Calculations were performed with Comprehensive Meta-Analysis software using the random effects model. Heterogeneity was tested by using Cochrane's Q and I2 statistics. Mean difference(MD) and OR(odds ratio) were calculated.RESULTS1063 articles(EMBASE: 589; PubM ed: 459; Cochrane: 15) were found in total. 5 retrospective articles and 1 prospective study were available for analysis. These 6 articles contained data on 406035 patients, of whom 51315 had impaired renal function. The analysis showed a higher mortality in the CKD group(OR = 1.786, 95%CI: 1.689-1.888, P < 0.001) and the ESRD group(OR = 2.530, 95%CI: 1.386-4.616, P = 0.002), and a rebleeding rate(OR = 2.510, 95%CI: 1.521-4.144, P < 0.001) in patients with impaired renal function. CKD patients required more unit red blood cell transfusion(MD = 1.863, 95%CI: 0.812-2.915, P < 0.001) and spent more time in hospital(MD = 13.245, 95%CI: 6.886-19.623, P < 0.001) than the controls.CONCLUSION ESRD increases mortality, need for transfusion, rebleeding rate and LOH among GI bleeding patients. Prospective patient registries and observational clinical trials are crucially needed. | Roland Hágendorn Nelli Farkas Aron Vincze Zoltán Gyongyi Dezso Csupor Judit Bajor Bálint Eross Péter Csécsei Andrea Vasas Zsolt Szakács László Szapáry Péter Hegyi Alexandra Mikó | 2017 | World Journal of Gastroenterology2017，23，47： | 3 |
| 5 | Ecosystem services and legal protection of private property.Problem or solution?显示文摘Ecosystem services(ES)delivery in quantity and quality are essential to improve human wellbeing.Nevertheless,often a considerable part of ES provisioning depends on the use of private land(e.g.,flood retention,carbon sequestration,water purification).In this context,the operationalization and implementation of ES concept may collide with legal property rights.Therefore,it is essential to find constructive mechanisms to engage and encour-age private owners to implement sustainable land uses to reduce the onsite and offsite impacts of their activities.This paper aims to identify if ES delivery can be constrained by legal private land and how it can be tackled.It is undeniable that land-use changes(e.g.,urbanization,agriculture intensification,and land abandonment)affect the territory’s capacity to deliver ES in quality and quantity.These changes,especially land abandonment,are in-creasing the tradeoffs among ES(e.g.,between carbon sequestration and water yield).Land-use planning should consider these aspects.Therefore,incorporating ES into spatial plans is crucial for stakeholders to understand the impacts of land-use change in the loss of ES value.This information can be transmitted through maps that communicate the message in a simplified way.Private owners can easily perceive the ES relevance that their land can provide if an understandable message is delivered.Although this can be a good solution,conflicts can appear even with the implementation of schemes such as Payment for ES(PES).PES is not always effective and can im-pose losses to farmers,disregard their cultural traditions,or not prevent poverty alleviation.In this context,it is crucial to consider local specificities to safeguard PES’s success,create a“win-win”and transform a problem into a solution.Private owners’active participation in implementing sustainable practices or a determined land-use in their properties is vital to achieving global targets such as sustainable development goals. | Katažyna Mikša Marius Kalinauskas Miguel Inácio Eduardo Gomes Paulo Pereira | 2020 | Geography and Sustainability2020，1，3： | 2 |
| 6 | Quality of life in patients with anorectal malformations or hirschsprung's disease:the development of a disease-specific questionnaire显示文摘 | Hanneman MJ Sprangers MA De Mik EL | 2001 | Dis Colon Rectum2001，44，： | 1 |
| 7 | Fractionally integrated generalized autoregressive conditional heteroskedasticity显示文摘 | Baillie R T Bollerslev T MIK Kelsen H O | 1996 | Journal of Econometrics1996，74，1： | 1 |
| 8 | A natural modal expansion for the flexible robot arm problem via a self-adjoint formulation显示文摘 | Chait Y Mik(l)avc(I)c M Maccluer C R | 1990 | IEEE Transaction on Robotics and Automation1990，6，5： | 1 |
| 9 | Toward assessment of blood oxygen saturation by spectroscopic optical coherence tomography显示文摘 | FABER D J MIK E G AALDERS M C G | 2005 | Optics Letters2005，30，9： | 1 |
| 10 | Influence of fluid resuscitation on renal microvascular PO2 in a normotensive rat model of endotoxemia显示文摘 | Johannes T Mik EG Nohe B | 2006 | Crit Care2006，10，3： | 1 |
| 11 | NONRESUSCITATED ENDOTOXEMIA INDUCES MICROCIRCULATORY HYPOXIC AREAS IN THE RENAL CORTEX IN THE RAT显示文摘 | Tanja Johannes Egbert G. Mik Can Ince | 2009 | Shock2009，，1： | 1 |
| 12 | Low dose dexamethasone-supplemented fluid resuscitation reverses endotoxin-induced acute renal failure and prevents cortical microvascular hypoxia 显示文摘 | Johannes T Mik EG Klingel K eta| | 2009 | Shock2009，31，5： | 1 |
| 13 | Auditory brainstem responses in children with congenital heart disease显示文摘 | Okutan V Demirkaya S Lenk MIK | 1994 | Pediatr Int1994，41，62： | 1 |
| 14 | Mitogenic activity of cementum component to gingival fibroblasts显示文摘 | Mik Y Narayanan AS Page RC | 1987 | J Dent Res1987，66，8： | 1 |
| 15 | 查看详情显示文摘 | D Kaszlikowski P Gnacinski M Zukowski W Mik laszewski and A Zeilinger | | 0，，21： | 1 |
| 16 | An empirical study of volatility in seven Southeast Asian stock markets using ARV models显示文摘 | Miks S Lam K Li W K | 1997 | Journal of Business Finance and Accounting1997，24，2： | 1 |
| 17 | Analysis of method for measuring thickness of plane-parallel plates and lenses using chromatic confocal sensor 显示文摘 | Miks A Novak A Novak P | 2010 | ApplOpt2010，49，17： | 1 |
| 18 | Effect of cellular differentiation on 11 beta - hydroxysteroid dehydrogenase activity in the intestine 显示文摘 | Pcha J Lis V Mik k | 2002 | Steroids2002，67，2： | 1 |
| 19 | Preparative procedures and purity assessment of collagen proteins显示文摘 | Z Deyl I Miks'k A Eckhardt | 2003 | Journal of Chromatography B2003，790，： | 1 |
| 20 | Open and closed haemorrhoidectomy for fourth degree haemorrhoids comparative one center study显示文摘 | Mik M Rzetecki T Sygut A | 2008 | Acta Chir Iugosl2008，55，3： | 1 |
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