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| 1 | NKX2-3 and IRGM variants are associated with diseasesu sceptibility to IBD in Eastern European patients显示文摘AIM: To investigate variants of immunity-related GT-Pase family M (IRGM) and NKX2-3 genes and genotype-phenotype in Eastern European patients with inflammatory bowel disease (IBD).METHODS: We analyzed 1707 Hungarian and Czech subjects with Crohn’s disease (CD) (n = 810, age: 37.1 ± 12.6 years, duration: 10.7 ± 8.4 years) and ulcerative colitis (UC) (n = 428, age: 43.7 ± 15.0 years, duration: 12.6 ± 9.9 years), as well as 469 healthy controls. IRGM rs13361189, NKX2-3 rs10883365 and ECM1 rs13294 polymorphisms were tested by LightCy-cler allele discrimination. Detailed clinical phenotypes were determined by reviewing the medical charts. RESULTS: NKX2-3 rs10883365 variant allele was as-sociated with increased risk for CD (P = 0.009, OR = 1.24, 95% CI = 1.06-1.48) and UC (P = 0.001, OR = 1.36, 95% CI = 1.13-1.63), whereas variant IRGM allele increased risk for CD (P = 0.029, OR = 1.36, 95% CI = 1.03-1.79). In contrast, ECM1 rs13294 was not associat-ed with either CD or UC. In CD, the variant IRGM allele was associated with a colon-only location (P = 0.02, OR = 1.62, 95% CI = 1.07-2.44), whereas in UC, the ECM1 variant was associated with cutaneous manifestations (P = 0.002, OR = 3.36, 95% CI = 1.48-7.63). Variant alleles did not predict resistance to steroids or azathio-prine, efficacy of infliximab, or need for surgery. CONCLUSION: NKX2-3 and IRGM are susceptibility locifor IBD in Eastern European patients. Further studies are needed to confirm the reported phenotype-genotype associations. | Nora Meggyesi Lajos S Kiss Magdalena Koszarska Martin Bortlik Dana Duricova Laszlo Lakatos Tamas Molnar Martin Lenicek Libor Vítek Istvan Altorjay Maria Papp Zsolt Tulassay Pal Miheller Janos Papp Attila Tordai Hajnalka Andrikovics Milan Lukas Peter Laszlo Lakatos | 2010 | World Journal of Gastroenterology2010，16，41： | 2 |
| 2 | Bioavailability of sorbed-phase and separate-phase chemicals显示文摘 | Mihelic J R Lueking D R Mitzell R J | 1993 | Biodegradation1993，4，3： | 1 |
| 3 | Clinical relevance of changes in bone metabolism in inflammatory bowel disease显示文摘Low bone mineral density is an established, frequent, but often neglected complication in patients with inflammatory bowel disease (IBD). Data regarding the diagnosis, therapy and follow-up of low bone mass in IBD has been partially extrapolated from postmenopausal osteoporosis; however, the pathophysiology of bone loss is altered in young patients with IBD. Fracture, a disabling complication, is the most important clinical outcome of low bone mass. Estimation of fracture risk in IBD is difficult. Numerous risk factors have to be considered, and these factors should be weighed properly to help in the identification of the appropriate patients for screening. In this editorial, the authors aim to highlight the most important clinical aspects of the epidemiology, prevention, diagnosis and treatment of IBD-related bone loss. | Pal Miheller Katalin Lrinczy Peter Laszlo Lakatos | 2010 | World Journal of Gastroenterology2010，16，44： | 1 |
| 4 | Comparison of the effects of 1,25 dihydroxyvitamin D and 25 hydroxyviamin D on bone pathology and disease activity in Crohn' s disease patients显示文摘 | Miheller P Muzes G Hritz I | | 0，，： | 1 |
| 5 | Efficacy and safety of in- fliximab induction therapy in Crohn' sDisease in CentraIEurope -aHungarian nationwide obser-vational study 显示文摘 | Miheller P Lakatos P L Horv6th G | 2009 | BMC Gastroen- tero12009，9，： | 1 |
| 6 | Bone morphogenetic protein- 7 ( osteogenic pretein-1 ) promotes tendon graft integration in ante- rior cruciate ligament reconstruction in sheep 显示文摘 | Mihelic R Pecina M Jelic M | 2004 | Am J Sports Med2004，32，7： | 1 |
| 7 | Knowledge - complexes and the Locus of Technological Change : The Biotechnology Sector in Oxford shire显示文摘 | Helen Lawton Smith David Mihell and David Kingham | 2000 | Area2000，32，2： | 1 |
| 8 | Microbial community structure during composting with and without massinocula显示文摘 | Boha S V Mihelic R Lobnik F | 2003 | Compost Science and Utilization2003，11，1： | 1 |
| 9 | Temperature distribution effects during polymerization of methacrylate-based monoliths显示文摘 | Mihelic I Koloini T Podgornik A | 2003 | Journal of Applied Polymer Science2003，87，14： | 1 |
| 10 | The Behavior of Matrix metallo- proteinase - 9 in lymphocytic colitis, collagenous colitis and ulcer - ative eolitis显示文摘 | Lakatos G Sipos F Miheller P | 2011 | Pathol Oncol Res2011，7，16： | 1 |
| 11 | Matrix Metalloproteinase-9 Expression in the Normal Mucosa–Adenoma–Dysplasia–Adenocarcinoma Sequence of the Colon显示文摘 | László Herszényi Ferenc Sipos Orsolya Galamb Norbert Solymosi István Hritz Pál Miheller Lajos Berczi Béla Molnár Zsolt Tulassay | 2008 | Pathology & Oncology Research2008，，1： | 1 |
| 12 | Bone morphogenetic protein-7 (osteogenic protein-1 ) promotes tendon graft integration in anteriorcruciate ligament reconstruction in sheep 显示文摘 | Mihelic R Pecina M Jelic M | 2004 | Am J Sports Med2004，32，： | 1 |
| 13 | Microbial community structure during composting with and without mass inocula 显示文摘 | Bolta S V Mihelic R Lobnik F | 2003 | Compost Science and Utilization2003，11，1： | 1 |
| 14 | Long-term results of anterior cruciate ligament reconstruction:a comparison with non-operative treatment with a follow-up of 17-20years显示文摘 | Mihelic R Jurdana H Jotanovic Z | 2011 | Int Orthop2011，7，： | 1 |
| 15 | Diurnally resolved particulate and VOC measurements at a rural site: indication of significant biogenic secondary organic aerosol formation显示文摘 | Sjostedt S. J. Slowik J. G. Brook J. R. Chang R. Y.-W. Mihele C. Stroud C. A. Vlasenko A. Abbatt J. P. D | 2011 | Atmospheric Chemistry and Physics2011，，233： | 1 |
| 16 | Coeliac disease in a 15-year period of observation (1997 and 2011) in a Hungarian referral centre显示文摘 | Dorottya Kocsis Pál Miheller Katalin L?rinczy László Herszényi Zsolt Tulassay Károly Rácz Márk Juhász | 2013 | European Journal of Internal Medicine2013，，5： | 1 |
| 17 | Planer thick film pH electrode based on ruthenium dioxide hydrate显示文摘 | MIHELL JA ATRINSON JK | 1998 | Sens Actuators B1998，48，： | 1 |
| 18 | Microbial community Structure during composting with and without mass inocttla显示文摘 | Boha S V Mihelic R Lobnik F ct al | 2003 | Compost Science and Utiliztion2003，11，1： | 1 |
| 19 | Associations of the interleukin-1 gene locus polymorphisms with risk to hip and knee osteoarthritis: Gender and suhpopulation differences 显示文摘 | Kaarvam M H Jotanovic Z Mihelic R | 2013 | Scandinavian journal of immunology2013，77，2： | 1 |
| 20 | Planer thick film pH electrodes based on ruthemium dioxide hydrate显示文摘 | Mihell J A Atrinson J A | 1998 | Sensors and Actuators B1998，48，13： | 1 |
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