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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | Health and lifestyle risk factors for falls in a large population-based sample of older people in Australia显示文摘 | Michell RJ Watson WL Milat A | 2013 | J Safety Res2013，45，： | 1 |
| 3 | Late outcome after guide-wire forceps pereutaneous tracheostomy-a prospective, randomized comparison with open surgical tracheostomy 显示文摘 | Raine RI Michell WL Ruttmann TG | 1999 | Br J Anaesth1999，82，1： | 1 |
| 4 | Hyperlipimia, pregnancy and pancreatitis显示文摘 | De Chalain TMB Michell WL Berger GMB | 1988 | Surg Gyaecol Ohstet1988，167，6： | 1 |
| 5 | Resuscitation withhydroxyethyl starch improves renal function and lactate clearancein penetrating trauma in a randomized controlled study : theFIRST trial (fluids in resuscitation of severe trauma) 显示文摘 | James MF Michell WL Joubert IA | 2011 | J Br JAnaesth2011，107，5： | 1 |
| 6 | Resuscitation withhydroxyethyl starch improves renal function and lactate clear-ance in penetrating trauma in a randomized controlled study:the FIRST trial (Fluids in Resuscitation of Severe Trauma) 显示文摘 | James MF Michell WL Joubert IA | 2011 | Br J Anaesth2011，107，5： | 1 |
| 7 | Corticotropin-re- leasing factor: a possible key to gut dysfunction in the critically ill显示文摘 | Hill LT Kidson SH Michell WL | 2013 | Nutrition2013，29，78： | 1 |
| 8 | Postoperative pain control with a continuous infusion of epidural sufentanil in the intensive care unit: a comparision with epidural morphine显示文摘 | Dyer RA Anderson BJ Michell WL | 1990 | Anesth Analg1990，71，1： | 1 |
| 9 | Resuscitation withhydroxyethyl starch improve renal function and lactate clearance inpenetrating trauma in a randomized controlled study:the FIRST tri-al(Fluid in Resuscitation of Severe Trauma)显示文摘 | James MF Michell WL Joubert IA | 2011 | Br J Anaesth2011，107，5： | 1 |
| 10 | CD4^+ CD25^+ T regulatory cells suppress NK cell-mediated immunotherapy of cancer 显示文摘 | Mark JS Michele WL Teng JS | 2006 | J lmmunol2006，176，3： | 1 |
| 11 | Resuscitation with hydroxyethyl starch improve renal function and lactate clearance in penetrating trauma in a randomized controlled study: the FIRST trial (Fluid in Resuscitation of Severe Trauma)显示文摘 | James MF Michell WL Joubert IA | 2011 | Br J Anaesth2011，107，5： | 1 |
| 12 | Hyperlipimia,pregnancy and pancreatitis显示文摘 | De Chalain TMB Michell WL Berger GMB | 1988 | Surg Gynecol Obstet1988，167，6： | 1 |
| 13 | Hyperlipidemia pregnancy and pancreatitis显示文摘 | De Chalain riM Michell WL Berger GM | 1988 | Surg Gynecol Obstet1988，167，6： | 1 |
| 14 | Hyperlipidemia,pr-egnancy and pancreatitis显示文摘 | De Chalain TM Michell WL Berger GM | 1988 | Surg Gynecol Obstet1988，167，6： | 1 |
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