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| 1 | Effects of co-administration of methanol leaf extract of Catharanthus roseus on the hypoglycemic activity of metformin and glibenclamide in rats显示文摘Objective:To investigate the interacting effects of co-administration of methanol leaf extract of Catharanthus roseus(C.roseus) on the hypoglycemic activity of metformin as well as glibenclamide using experimental rats.Methods:Phytochemical analysis as well as acute toxicity and lethality(LD50) test were carried out on its methanol leaf extract.The alloxan model for experimental induction of diabetes in rats was employed.Six groups comprising five rats each were used.GroupsⅡ,ⅢandⅣreceived 250 mg/kg of extract,100 mg/kg of metformin and 1 mg/kg of glibenclamide respectively,while V and VI were administered metformin-extract and glibenclamide-extract combinations respectively at doses as above.Group I served as negative control and received only distilled water.All administration was done once daily for seven days. Fasting blood glucose was determined at 2,12,24,72 and 168 h using a glucometer.One-way ANOVA with post-hoc tests was used to assess for significant difference due to administration of drug alone and with co-administration of drug and extract.Results:The LD50 was 2 121.32 mg/kg. The phytochemical studies indicated the presence of saponins,tannins,alkaloids,phlotatannins, flavonoids,triterpenoids,reducing sugars,anthraquinones and glycosides.All medicaments significantly reduced blood glucose levels when compared with control alone(P<0.05) with the highest percentage reduction in blood glucose(64.86%) exhibited by metformin-extract combination.Conclusions:The leaf extract of C.roseus significandy increases the hypoglycemic effect of metformin. | Ohadoma SC Michael HU | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，6： | 2 |
| 2 | Biofilm formation by Pneumocystis 显示文摘 | Melanie TC Margaret SC Michael JL | 2009 | Eukaryot Cell2009，8，2： | 1 |
| 3 | Five-year reproducibility of natural head posture:A longitudinal study显示文摘 | Michael SC | 1990 | Am J Orthod Dentofac Orthop1990，97，： | 1 |
| 4 | Risk factors for kaposi′s sarcoma in men seropositive for both human herpesvirus 8 and human immunocleficiency virus显示文摘 | Michael J Cannon SC JB | | 0，，： | 1 |
| 5 | Immune-correlates analysis of an HIV-1 vaccine efficacy trial 显示文摘 | Haynes BF Gilbert PB McElrath MJ Zolla-Pazner S Tomaras GD Alam SM Evans DT Montefiori DC Kar- nasuta C Sutthent R Liao HX DeVico AL Lewis GK Williams C Pinter A Fong Y Janes H DeCamp A Huang Y Rao M Billings E Karasavvas N Robb ML Ngauy V de Souza MS Paris R Ferrari G Bailer RT Soderberg KA Andrews C Berman PW Frahm N De Ro- sa SC Alpert MD Yates NL Shen X Koup RA Pitisut- tithum P Kaewkungwal J Nitayaphan S Rerks-Ngarm S Michael NL Kim JH | 2012 | N Engl J Med2012，366，14： | 1 |
| 6 | Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling 显示文摘 | Yiannis SC Ahmet UC Michael J | 2007 | J Am Coil Cardiol2007，49，： | 1 |
| 7 | Congenital cholesteatoma of the middle ear in children:origin and management显示文摘 | Levenson ML Michaels L Parisier SC | 1989 | Otolaryngol Clin North Am1989，22，： | 1 |
| 8 | The heart remembers 显示文摘 | Michael RR Ira SC Peter DJ | 1998 | Cardiovasc Res1998，40，： | 1 |
| 9 | A 41-Year-Old HIV-Positive Man with Acute Onset of Quadriplegia after West Nile Virus Infection 显示文摘 | Jamison SC Michaells SR Ratard R | 2007 | South Med J2007，100，10： | 1 |
| 10 | Effect of the head posture on cephralometric sagittal angular measures显示文摘 | Tommy CK C Michael SC | 1993 | Am J Orthod Dentalfac Orthop1993，104，4： | 1 |
| 11 | Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling显示文摘 | Yiannis SC Ahmet UC Michael J | 2007 | J Am Coll Cardiol2007，49，： | 1 |
| 12 | The ideal small arterial sustitue a research for the helyh grail显示文摘 | Michael SC | 1998 | FASEB1998，12，1： | 1 |
| 13 | Prediction of the localization of high-risk coronary atherosclerotic plaques on the basis of low endothelial shear stress显示文摘 | Yiannis SC Michael J Ahmet UC | 2008 | Circulation2008，117，： | 1 |
| 14 | Inhibition of myocardiainjury by ischemic postconditioning duringreperfusion:comparison with ischemic preconditioning显示文摘 | Zhao ZQ Joel SC Michael EH | 2003 | Am J Physiol Heart Circ Physiol2003，285，2： | 1 |
| 15 | The pathology of superficialsiderosis of the central nervous system显示文摘 | Koeppen AH Michael SC Li D | 2008 | Acta Neuropathol2008，116，： | 1 |
| 16 | Effect of the head pos- ture on cephalometric sagittal angular measures显示文摘 | Tommy CKC Michael SC | 1993 | Am J Orthod Dentofac Orthop1993，104，4： | 1 |
| 17 | Ultrasound in the di- agnosis of ulnar neuropathy at the cubital tunnel显示文摘 | Ethan RW George DC Michael SC | 2006 | J Hand Surg2006，31，： | 1 |
| 18 | Improved technique for transient expression and negative strand virus rescue using fowlpox T7 recombinant virus in mammalian cells显示文摘 | Das SC Michael D Michael B | 2000 | J Virol Methods2000，89，： | 1 |
| 19 | Acoustic characteristics of Parkinsonian speech : a potential biomarker of early disease pro- gression and treatment 显示文摘 | Brian TH Michael SC Henrf C | 2004 | Journal of Neurolinguistics2004，17，6： | 1 |
| 20 | Congenital cholesteatoma in children an embryologic correlation显示文摘 | Levenson MJ Michaels L Parisier SC | 1988 | Laryngoscope1988，98，9： | 1 |
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