| 4 | Genetic variants in XPD gene and glioma susceptibility in Chinese children:A multicenter case–control study显示文摘Background:Glioma is one of the central nervous system(CNS)tumors in children,accounting for 80%of malignant brain tumors.Nucleotide excision repair(NER)is a vital pathway during DNA damage repair progression.Xeroderma pigmentosum group D(XPD)or excision repair cross‐complementing group 2(ERCC2)is a critical factor in the NER pathway,playing an indispensable role in the DNA repair process.Therefore,the genetic variants in XPD may be associated with carcinogenesis induced by defects in DNA repair.Methods:We are the first to conduct a multi‐center case‐control study to investigate the correlation between XPD gene polymorphisms and pediatric glioma risk.We chose three single nucleotide polymorphisms and genotyped them using the TaqMan assay.Results:Although there is no significant association of these genetic variations with glioma susceptibility,the stratified analysis revealed that in the subtype of astrocytic tumors,the rs13181 TG/GG genotype enhanced glioma risk than the TT genotype,and carriers with two to three genotypes also elevated the tumor risk than 0‐1 genotypes.Conclusion:In conclusion,our findings provided an insight into the impact of XPD genetic variants on glioma risk. | Yong‐Ping Chen Yuxiang Liao Li Yuan Xiao‐Kai Huang Ji‐Chen Ruan Hui‐Ran Lin Lei Miao Zhen‐Jian Zhuo | 2022 | Cancer Innovation2022，1，1： | 0 |
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