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| 1 | Epithelial-mesenchymal transition as a therapeutic target for overcoming chemoresistance in pancreatic cancer显示文摘Pancreatic cancer has one of the worst prognoses among all cancers due to the late manifestation of identifiable symptoms and high resistance to chemo- and radiation therapies. In recent years, a cancer development phase termed epithelial-mesenchymal transition(EMT) has gained increasing research focus. The process is implicated in tumour metastasis, and emerging evidence suggests EMT also contributes or induces chemoresistance in several cancers. Nevertheless, the applicability of therapeutic targeting of EMT faces many challenges. In this mini-review, we summarise the evidence supporting the role of EMT in pancreatic cancer progression, focusing particularly on its association with chemoresistance. | Omar Elaskalani Norbaini Binti Abdol Razak Marco Falasca Pat Metharom | 2017 | World Journal of Gastrointestinal Oncology2017，9，1： | 6 |
| 2 | Endothelial progenitor cells显示文摘 | Doyle B Metharom P Caplice NM | | 0，，： | 1 |
| 3 | The significance of controlled conditions in lentiviral vector titration and in the use of multiplicity of infection (MOI) for predicting gene transfer events显示文摘 | Zhang B Metharom P Jullie H | 2004 | Genetic Vaccines and Therapy2004，2，： | 1 |
| 4 | The significance of controlled conditions in lentiviral vector titration and in theuse of multiplicity of infection (MOI) for predicting gene transfer events显示文摘 | ZHANG B METHAROM P JULLIE H | 2004 | Genetic Vaccines and Therapy2004，2，1： | 1 |
| 5 | Experimental-scrapie in pit mice: an assessment of the role of dendritic-cellmigration in the pathogenesis of prion diseases显示文摘 | Levavasseur E Metharom P Dorban G | 2007 | J Gen Vir-ol2007，88，8： | 1 |
| 6 | Lentiviral vector mediated tyrosinase-related protein 2 gene transfer to dendritic cells for the therapy of melanoma显示文摘 | Metharom P Ellem K A Schmidt C | | 0，，18： | 1 |
| 7 | Myeloid lineage of high pro- liferative potential human smooth muscle outgrowth cells circulat- ing in blood and vasculogenic smooth muscle-like cells in vivo 显示文摘 | Metharom P Liu C Wang S | 2008 | Atherosclerosis2008，198，： | 1 |
| 8 | Thrombin stimulates smoothmuscle cell differentiation from peripheral blood mononuclear cellsvia protease-activated receptor-1,RhoA,and myocardin显示文摘 | Martin K Weiss S Metharom P | 2009 | Circ Res2009，105，3： | 1 |
| 9 | Gene Transfer to Dendritic Cells Induced a Protective Immunity against Melanoma显示文摘Lentiviral vectors have shown promises for efficient gene transfer to dividing as well as nondividing cells. In this study, we explored lentiviral vector-mediated, the entire mTRP-2 gene transfer and expression in dendritic cells (DCs). Adoptive transfer of DCs-expressing mTRP-2 (DC-HR'CmT2) into C57BL/6 mouse was also assessed.Dendritic cells were harvested from bone marrow and functional DCs were proved by allogeneic mixed lymphocyte reaction. Lentiviral vectors were produced by transient transfection of 293T cells. Transduction of DCs was proved by marker gene expression and PCR and RT-PCR amplification. Implantation of the transduced DCs, depletion of immune cells as well as the survival of the mice after tumour challenge were investigated. High efficiency of gene transfer into mature DCs was achieved. The high level expression of the functional antigen (TRP-2) and induction of protective immunity by adoptive transfer of TRP-2 gene modified DCs were demonstrated. In vivo study showed a complete protection of mice from further melanoma cell challenge. In comparison, only 83% of mice survived when mTRP-2 peptide-pulsed DCs were administered, suggesting the generation of specific protection. Together, these results demonstrated the usefulness of this gene transfer to DC approach for immunotherapy of cancer and indicated that using tumour associated antigens (TAAs) for gene transfer may be potentially beneficial for the therapy of melanoma. | Pat Metharom Kay A.O. Ellem Ming Q. Wei | 2005 | Cellular & Molecular Immunology2005，2，4： | 1 |
| 10 | The significance of controlled conditions in lentiviral vector titration and in the use of multiplicity of infection (MOI) for predicting gene transfer events 显示文摘 | Zhang B Metharom P Jullie H | 2004 | Genet Vaccines Ther2004，2，1： | 1 |
| 11 | The functional role of platelets in the regulation of angiogenesis 显示文摘 | WALSH T G METHAROM P BERNDT M C | 2015 | Platelets2015，26，3： | 1 |
| 12 | Experimental scrapie in 'plt' mice: an assessment of the role of dendritic- cell migration in the pathogenesis of prion diseases 显示文摘 | Levavasseur E Metharom P Dorban G | 2007 | Gen Virol2007，88，8： | 1 |
| 13 | High molecular weight plas-ma proteins induce apoptosis and Fas/FasL expression in human proxi-mal tubular cells显示文摘 | Morais C Westhuyzen J Metharom P | 2005 | Nephrol Dial Transplant2005，20，1： | 1 |
| 14 | Myeloid lineage of human endo-thelial outgrowth cells circulating in blood and vasculogenic endothelial-like cells in the diseased vessel wall 显示文摘 | Liu C Wang S Metharom P | 2009 | J Vase Res2009，46，6： | 1 |
| 15 | Primary haemostasis: newer insights 显示文摘 | Berndt MC Metharom P Andrews RK | 2014 | Haemophilia2014，20，4： | 1 |
| 16 | Search for“Weapons of Mass Destruction”for Cancer-Immuno/Gene Therapy Comes of Age显示文摘The complexity of a cancer, such as cell heterogeneity, and the existence of hypoxia, stromal cells and stem cells has present, the use of conventional therapies, such as chemo/radio therapy is limited, and only therapies that are so far prevented successful development and treatment of patients suffering from the later stages of cancers. At focused on utilizing the patient's immune response to combat against the disease appear to be the most reliable and promising. Two decades ago, cytokines were discovered to be able to activate the imnune systems and mount an anti-tumour response. Then, dendritic cells were hailed as the most significant regulators of immunity and are employed in a variety of cancer management schemes. This review introduces current development in the field,focusing on combination of the components of the rapidly growing fields of immunotherapy and gene transfer/therapy, providing useful and significant detailed information for readers of cellular and molecular immunology. Cellular & Molecular Immunology. | Ming Q. Wei Pat Metharom Kay A.O. Ellem Stefan Barth | 2005 | Cellular & Molecular Immunology2005，2，5： | 0 |
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