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| 1 | 急性脊髓损伤患者治疗的临床操作指南:关于MRI基线在临床治疗决策与结果预测中作用的几点建议(英文)显示文摘The objective of this guideline is to outline the role of magnetic resonance imaging(MRI) in clinical decision making and outcome prediction in patients with traumatic spinal cord injury(SCI).Methods A systematic review of the literature was conducted to address key questions related to the use of MRI in patients with traumatic SCI.This review focused on longitudinal studies that controlled for baseline neurologic status.A multidisciplinary Guideline Development Group(GDG) used this information,their clinical expertise,and patient input to develop recommendations on the use of MRI for SCI patients.Based on GRADE(Grading of Recommendation,Assessment,Development and Evaluation),a strong recommendation is worded as ' we recommend,' whereas a weaker recommendation is indicated by 'we suggest.' Results Based on the limited available evidence and the clinical expertise of the GDG,our recommendations were:(1) 'We suggest that MRI be performed in adult patients with acute SCI prior to surgical intervention,when feasible,to facilitate improved clinical decision-making'(quality of evidence,very low) and(2) 'We suggest that MRI should be performed in adult patients in the acute period following SCI,before or after surgical intervention,to improve prediction of neurologic outcome '(quality of evidence,low).Conclusions These guidelines should be implemented into clinical practice to improve outcomes and prognostication for patients with SCI. | Fehlings MG Martin AR Tetreault LA Aarabi B Anderson P Arnold PM Brodke D Burns AS Chiba K Dettori JR Furlan JC Hawryluk G Holly LT Howley S Jeji T Kalsi-Ryan S Kotter M Kurpad S Kwon BK Marino RJ Massicotte E Merli G Middleton JW Nakashima H Nagoshi N Palmieri K Singh A Skelly AC Tsai EC Vaccaro A Wilson JR Yee A Harrop JS | 2017 | 中华神经外科疾病研究杂志2017，16，6： | 8 |
| 2 | Evaluation of a locked nucleic acid form of antisense oligo targeting HIF-1α in advanced hepatocellular carcinoma显示文摘BACKGROUND Hypoxia-inducible factor 1α(HIF-1α) is a gene that regulates tumor survival,neovascularization and invasion. Overexpression of HIF-1α correlates with poor prognosis in hepatocellular carcinoma(HCC). RO7070179 is a HIF-1α inhibitor that decreases HIF-1α mRNA and its downstream targets, it could be a potential treatment in HCC.AIM To evaluate safety and preliminary activity of RO7070179 in patients with previously treated HCC, with focus on a patient with prolonged response to RO7070179.METHODS In the preclinical study of RO7070179 in a HCC xenograft model, the mice wereseparated into 4 groups with each group received doses of 0, 3, 10 and 30 mg/kg for total 10 doses. HCC patients who failed at least one line of systemic treatment,received RO7070179 as a weekly infusion, each cycle is 6 wk. We evaluated the safety and HIF-1α mRNA levels of RO7070179.RESULTS Preclinical evaluation of RO7070179 in orthotopic HCC xenograft model showed no significant differences in HCC tumor weight between the 3 and 10 mg/kg groups. However, dose of 10 mg/kg of RO7070179, has shown 76% reduction of the amount of HIF-1α mRNA in HCC tissue. In the phase 1 b study of RO7070179 in previously treated HCC patients, 8 out of 9 were evaluable: 1 achieved PR and1 SD. The patient with PR responded after 2 cycles treatments, which has been maintained for 12 cycles. This patient also showed reduction in perfusion of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI) after 1 cycle of treatment. After 1 cycle of treatment, both patients with PR and SD showed decrease in HIF-1α mRNA at the root of biopsies(each biopsy was divided into 2 specimens, the tip and the root).CONCLUSION RO7070179 can reduce HIF-1α mRNA level in HCC patients with SD or PR. It is well tolerated at 10 mg/kg, with transaminitis as the dose of increased toxicity.This study indicates that RO7070179 might benefit HCC patients, and an early signal for clinical benefit can potentially be predicted through changes in either m RNA level or DCE-MRI within 1 cycle of therapy. | Jennifer Wu Merly Contratto Krishna P Shanbhogue Gulam A Manji Bert H O'Neil Anne Noonan Robert Tudor Ray Lee | 2019 | World Journal of Clinical Oncology2019，10，3： | 2 |
| 3 | Endothelial dysfunction in acute and chronic coronary syndromes: evidence for a pathogenetic role of oxidative stress显示文摘 | Valgimigli M Merli E Malagutti P | 2003 | Arch Biochem Biophys2003，420，2： | 1 |
| 4 | Treatment of industrial landfill leachate by means of evaporation and reverse osmosis 显示文摘 | Palma L D Ferrantelli P Merli C | 2002 | Waste Management2002，22，8： | 1 |
| 5 | Recovery of EDTA and metal precipitation from soil flushing solution 显示文摘 | Ferrantelli P Di Palma L Merli C | 2003 | Journal of Haz- ardous Materials2003，103，： | 1 |
| 6 | Hydroxyl radicalgeneration,levels of tumor necrosis factor-alpha,and progres-sion to heart failure after acute myocardial infarction显示文摘 | Valgimigli M Merli E Malagutti P | 2004 | J AmColl Cardiol2004，43，11： | 1 |
| 7 | T cell therapy for na- sopharyngeal carcinoma 显示文摘 | Basso S Zecca M Merli P | 2011 | J Cancer2011，2，： | 1 |
| 8 | Endothelial dysfunction in acute and chronic coronary syndromes:evidence for a pathogenetic role of oxidative stress显示文摘 | Merli E Malagutti P | 2003 | Arch Biochem Biophys2003，420，2： | 1 |
| 9 | Hydroxyl radical generation, levels of TNF-c, and progression to heart failure after acute myocardial infarction 显示文摘 | Valgimigli M Merli E Malagutti P | 2004 | J Am Coil Cardio12004，43，11： | 1 |
| 10 | Risk factors and early extracoronary atheroselerotic plaque detected by three side ultrasound imaging in hypercholesterolemic men 显示文摘 | Giral P Pithois Merli I Filitti V | 1991 | Arch Intern Med1991，151，13： | 1 |
| 11 | Endothelial dysfunction in acute and chronic coronary Syndromes:evidence for a pathogenetic role of oxidative stress显示文摘 | Valgimigli M Merli E Malagutti P | 2003 | Arch Biochem Biophys2003，420，： | 1 |
| 12 | Endothelial dysfunction in acute and chronic coronary syndromes:evi1dence for a pathogenetic role of oxidative stress显示文摘 | Valgimigli M Merli E Malagutti P | 2003 | Arch Biochem Biophys2003，420，2： | 1 |
| 13 | Anovelsynapse- associated noncoding RNA显示文摘 | Velleca M A Wallace M C Merlie J P | 1994 | Mol Cell Biol1994，14，： | 1 |
| 14 | Ehlers-Danlos syndrome and neurological features: a review显示文摘 | Savasta S Merli P Ruggieri M | 2011 | Childs Nerv Syst2011，27，： | 1 |
| 15 | Hydroxyl radical generation,levels of tumor necrosis factor-alpha,and progression to heart failure after acute myocardial infarction显示文摘 | Valgimigli M Merli E Malagutti P | 2004 | J Am Coll Cardiol2004，43，11： | 1 |
| 16 | Endothelial dysfunction in acute and chronic coronary syndromes: evidence for a pathogenetic role of oxidative stress 显示文摘 | Valgimili M Merli E Malagutti P | 2003 | Arch Biochem Biophys2003，420，2： | 1 |
| 17 | Costs of hospital visits among patients with deep vein thrombosis treated with rivaroxaban and LMWH/warfarin显示文摘 | MERLI GJ HOLLANDER JE LEFEBVRE P | 2016 | J Med Econ2016，19，1： | 1 |
| 18 | Current and future approaches to treat graft failure after allogeneic hematopoietic stem cell transplantation 显示文摘 | Locatelli F Lucarelli B Merli P | 2014 | Expert Opin Pharmacother2014，15，： | 1 |
| 19 | Clofarabine, cyclophosphamide and etoposide as single- course re-induction therapy for children with refractory/multiple re- lapsed acute lymphoblastie leukaemia显示文摘 | Loealelli F Testi AM Benlardo ME Rizzari C Bertaina A Merli P | 2009 | Br J Haematol2009，147，3： | 1 |
| 20 | Endothelial dysfunction in acute and chronic coronary syndromes:evidence for a pathogenetic role of oxidative stress显示文摘 | Valgimigli M Merli E Malagutti P | | 0，，02： | 1 |
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