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| 1 | A compound radial artery forearm flap in hand surgery: an original modification of the Chinese forearm flap显示文摘 | Foucher G van Genechten F Merle N | 1984 | Br J Plast Surg1984，37，2： | 1 |
| 2 | Preparation of a well- defined silica-supported nickel diimine alkyl complex applieation for the gas-phase polymerization of ethylene 显示文摘 | A Dorcier N Merle M Taoufik | 2009 | Organometallics:2009，28，： | 1 |
| 3 | A compound radial artery, forearm flap in hand surgery:an original modification of the Chinese forearm flap 显示文摘 | Foucher G van Genechten F Merle N | 1984 | Br J Plast Surg1984，37，： | 1 |
| 4 | Complications from Silicon-polymer Intubulation of Nerves显示文摘 | Merle M Dellon A L Campbell J N | 1989 | Microsurgery1989，10，2： | 1 |
| 5 | Uncertainty Management Intervention for Older African American and Caucasian- Long-Term Breast Cancer Survivors显示文摘 | Karen M G Merle H Mishel R N | 2005 | J Psychosoc On- col2005，23，23： | 1 |
| 6 | Different quantitati ve apoptotic traits in coronary atherosclerodc plaques from patient' s with Stable angina pectofis and acute coronary syndromes 显示文摘 | Rossi ML Marziliano N Merl ini PA | 2004 | Cir- culation2004，110，2： | 1 |
| 7 | Ribozymes targeted to stearoyl-ACP △^9 desaturase mRNA produce heritable increases of stearic acid in transgenie maize leaves 显示文摘 | Merle A O Cowen N Delate T | 1998 | The Plant Cell1998，10，10： | 1 |
| 8 | Ocular burns显示文摘 | Merle H Gérard M Schrage N | | 0，，05： | 1 |
| 9 | ATAD3B is a human embryonic stem cell specific mitochondrial protein,re expressed in cancer cells,that functions as dominant negative for the ubiquitous ATAD3A显示文摘 | Merle N Féraud O Gilquin B | 2012 | Mitochondrion2012，12，： | 1 |
| 10 | Spontaneous formation of bilayers and vesicles in mixtures of single-chain alkyl carboxylates : Effect of pH and aging and cy- totoxicity studies 显示文摘 | Vlachy N Merle C Touraud D | 2008 | Langmuir2008，24，： | 1 |
| 11 | “设”“艺”之间显示文摘在工作中,接触到很多设计师都不是本专业出身,而是美术、手工等纯艺术专业。观察这类设计师的作品,我们往往可以发现其与众不同的跳脱气质:它们或是在平面视觉上有脱俗亮眼的表现,或是简约而不简单,虽然没有繁复的造型和精致的编排布局,但就自然而然地让人感觉舒适、高雅。 | Bodegón Cabinet Max Enrich Goula Figuera Thomas Feichtner Siba Sahabi Weez and Merl KIMU Design Sabine Marcelis Bower Pedro Paulo Venzon Akos Huber Christian Lo Nina Johanna Christensen 彭佳 | 2018 | 现代装饰2018，0，11： | 0 |
| 12 | Pharmacological characterizationof synthetic cannabinoid MAM-2201:radioligand binding and abuse-related effects显示文摘OBJECTIVE Over 30% of all new psychoactive substances identified by the UN Office on Drugs and Crime in 2016 were synthetic cannabinoids.The recent emergence of MAM-2201 on the illicit market is troubling because this drug has no precedent in either the scientific or patent literature,and appears to be a novel compound developed specifically as a 'graymarket' drug of abuse bystructurally combining the known synthetic cannabinoids JWH-122 and AM-2201.There is currently no published information regarding the pharmacology of MAM-2201.METHODS The present studies characterized cannabinoid-like effects of MAM-2201 in vitro(interactions with cannabinoid type 1 receptors[CB1 Rs]) and in vivo(in mice and rats).RESULTS In a radioligand binding assay using [3 H]CP55,940 in HEK cell membranes transfected with the CB1 R,MAM-2201(K i=5.4 nmol·L^(-1)),had higher binding affinity than WIN 55,212-2(K i=80 nmol·L^(-1)),and D9-THC(K i=8.3 nmol·L^(-1)).The E max values for MAM-2201 and WIN 55,212-2 in an assay of agonist inhibition of forskolin-stimulated c AMP were 85%(EC50=0.45 nmol·L^(-1)) and 95%,respectively,as compared with the D9-THC E max of 74%.In mice,MAM-2201(0.003-1.0 mg·kg^(-1),IP) produced dose-dependent cannabimimetic effects which were both more potent and more effective than those of D9-THC.MAM-2201 and D9-THC dose-dependently produced hypothermia:ED50=0.287 and 25.4 mg·kg^(-1),analgesia:ED50=0.125 and 29.4 mg·kg^(-1),and catalepsy:ED50=0.301 and18.9 mg·kg^(-1) in adult male CD1 mice.Importantly,MAM-2201 also elicited convulsant effects at a dose of 1.0 mg·kg^(-1) in 8/8 murine subjects.In rats,MAM-2201 produced dose-dependent D9-THC-like interoceptive effects in subjects trained to discriminate 3.0 mg·kg^(-1)(IP) D9-THC from saline.CONCLUSION MAM-2201 binds CB1 Rs with high affinity and agonist efficacy,and functions as a potent cannabinoid agonist in vivo across several complementary measures of cannabinoid activity in two rodent species. | William E FANTEGROSSI Aaron JANOWSKY Amy J ESHLEMAN Lauren N RUSSELL Saki FUKUDA Jyoti GOGOI Cassandra PRIOLEAU Ambuja S BALE Srihari R TELLA Merle G PAULE Takato HIRANITA | 2017 | 中国药理学与毒理学杂志2017，31，10： | 0 |
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