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| 1 | 室外空气污染、早产和低出生体重:世界卫生组织孕产妇和围产期保健全球调查分析显示文摘[背景]吸入细颗粒物(颗粒物直径≤2.5μm,PM2.5)能诱发氧化应激和炎症反应,并有可能导致早产和其他不良的围产期结局。[目的]检测2004—2008年,世界卫生组织在全球22个国家中进行的孕产妇和围产期保健调查中,室外PM2.5是否与不良妊娠结局相关。[方法]以有新生儿出生的各医疗诊所周围50 km为半径的圆弧缓冲区计算室外PM2.5的长期均值(2001—2006年)。应用广义估计方程确定诊所的PM2.5水平与个体的早产和低出生体重之间的相关性,调整个人、诊所和国家水平的季节性因素及潜在的混杂因素。另外还对各国中的相关性进行了研究。[结果]在所有国家中,调整季节性因素后,PM2.5与早产无关联,但是与低出生体重相关[PM2.5的第四个四分位数段(〉20.2μg/m3)与第一个四分位数(〈6.3μg/m3)相比,比值比(OR)=1.22;95%CI:1.07-1.39]。中国是PM2.5测量值范围最大的国家,早产和低出生体重均仅与PM2.5的最高四分位数段相关,提示可能存在阈值效应(PM2.5≥36.5μg/m3与PM2.5〈12.5μg/m3相比,早产和低出生体重比值比分别为:OR=2.54;CI:1.42-4.55和OR=1.99;CI:1.06-3.72)。[结论]室外PM2.5浓度与低出生体重相关,但与早产不相关。在快速发展的国家中,例如中国,最高的空气污染水平可能与两个结局都相关。 | Nancy L.Fleischer Mario Merialdi Aaron van Donkelaar Felipe Vadillo-Ortega Randall V.Martin Ana Pilar Betran Jo?o Paulo Souza Marie S.O'Neill 王晓宇 汪源 金泰廙 | 2014 | 环境与职业医学2014，31，12： | 4 |
| 2 | Nutritional interven-tions during pregnancy for the prevention or treatment of mater-nal morbidity and preterm delivery:an overview of randomizedcontrolled trials显示文摘 | Villar J Merialdi M Gulmezoglu Am etal | 2003 | J Nutr2003，133，52： | 1 |
| 3 | Differences in the placental membrane cytokine response:apossible explanation for the racial disparity in preterm birth显示文摘 | Menon R Merialdi M Lombardi SJ | 2006 | Am J Reprod Immunol2006，56，2： | 1 |
| 4 | Rates of caesarean section: analysis of global, regional and national estimates 显示文摘 | Betran AP Merialdi M Lauer JA et a1 | 2007 | Paediatr Perinat Epidemiol2007，2，2： | 1 |
| 5 | World Health Organi-zation randomized trial of calcium supplementation among lowcalcium intake pregnant women显示文摘 | Villar J Abdel-Aleem H Merialdi M etal | 2006 | Am J Obstet Gynecol2006，194，3： | 1 |
| 6 | Wodd Health Organi- zation randomized trial of calcium supplementation among low calcium intake pregnant women显示文摘 | Villar J Abdel-Aleem H Merialdi M | 2006 | Am J Obstet Gynecol2006，194，3： | 1 |
| 7 | World Health Organi- zation randomized trial of calcium supplementation among low calcium intake pregnant women 显示文摘 | Villar J Abdel - Aleem H Merialdi M | 2006 | Am J Obstet Gynecol2006，194，3： | 1 |
| 8 | World Health Organization randomized trial of calcium supplementation a- mong low calcium intake pregnant women显示文摘 | VILLAR J ABDEL ALEEM H MERIALDI M | 2006 | Am J Obstet Gyne- col2006，194，3： | 1 |
| 9 | Nutritional interventions during pregnancy for the prevention or treatment of maternal morbidity and preterm delivery : an overview of randomized controlled trials显示文摘 | Villar J Merialdi M Gulmezoglu AM | 2003 | J Nutr2003，133，52： | 1 |
| 10 | Rates of caesarean section:analysis of global,regional and national estimates显示文摘 | Betrán AP Merialdi M Lauer JA | 2007 | Paediatr Perinat Epidemiol2007，21，2： | 1 |
| 11 | World Health Organization ran domized trial of calcium supplementation among low calcium intake pregnant women 显示文摘 | Villar J Abdel-Aleem H Merialdi M | 2006 | Am J Obstet Gynecol2006，194，3： | 1 |
| 12 | Safety of ultrasonography in pregnancy:WHO systematic review of the literature and meta-analysis显示文摘 | Torloni MR Vedmedovska N Merialdi M | | 0，，05： | 1 |
| 13 | Differences in the placental membrane cytokine response: a possible explanation for the racial disparity in preterm birth 显示文摘 | Menon R Merialdi M Lombardi S J | 2006 | Am J Reprod Immunol2006，56，2： | 1 |
| 14 | Rates of caesarean section: analysis of global, regional and national estimates显示文摘 | Betran AP Merialdi M Lauer JA | 2007 | Paediatr Perinat Epidemiol2007，21，2： | 1 |
| 15 | Adding zinc prenatal iron and folate tablets improves fetal neurobehavioral development显示文摘 | Merialdi M Caulfield LE Zavaleta N | 1998 | Am J Obstet Gynecol1998，180，2： | 1 |
| 16 | Rates of cesarean section: analysis of global, regional and national estimates 显示文摘 | Betrain AP Merialdi M Lauer JA | 2007 | Paediatr Perinat Epidemiol2007，21，2： | 1 |
| 17 | Rates of caesarean section:analysis of global,regional and national estimates显示文摘 | Betrain AP Merialdi M Lauer JA | 2007 | Paediatr Perinat Epidemiol2007，21，2： | 1 |
| 18 | World Health Or- ganisation muhicentre randomised trial of supplementation with vitamins C and E among pregnant women at high risk for pre-eelampsia in populations of low nutritional status from developing countries 显示文摘 | Villar J Purwar M Merialdi M | 2009 | Br J Obstot Gynaeol2009，116，6： | 1 |
| 19 | The worldwide incidence of preterm birth: a systematic review of maternal mortality and morbidity显示文摘 | Beck Stacy Wojdyla Daniel Say Lale Betran Ana Pilar Merialdi Mario Requejo Jennifer Harris Rubens Craig Menon Ramkumar Van Look Paul F A | 2010 | Bulletin of the World Health Organization2010，，1： | 1 |
| 20 | Differences inthe placental membrane cytokine response:A possible explanation for the racial disparity in preterm birth显示文摘 | Menon R Merialdi M Lombardi S | | 0，，2： | 1 |
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