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| 1 | Management of postoperative spinal infections显示文摘Postoperative surgical site infection(SSI) is a common complication after posterior lumbar spine surgery. This review details an approach to the prevention,diagnosis and treatment of SSIs. Factors contributing to the development of a SSI can be split into three categories:(1) microbiological factors;(2) factors related to the patient and their spinal pathology; and(3) factors relating to the surgical procedure. SSI is most commonly caused by Staphylococcus aureus. The virulence of the organism causing the SSI can affect its presentation. SSI can be prevented by careful adherence to aseptic technique,prophylactic antibiotics,avoiding myonecrosis by frequently releasing retractors and preoperatively optimizing modifiable patient factors. Increasing pain is commonly the only symptom of a SSI and can lead to a delay in diagnosis. C-reactive protein and magnetic resonance imaging can help establish the diagnosis. Treatment requires acquiring intra-operative cultures to guide future antibiotic therapy and surgical debridement of all necrotic tissue. A SSI can usually be adequately treated without removing spinalinstrumentation. A multidisciplinary approach to SSIs is important. It is useful to involve an infectious disease specialist and use minimum serial bactericidal titers to enhance the effectiveness of antibiotic therapy. A plastic surgeon should also be involved in those cases of severe infection that require repeat debridement and delayed closure. | Vishal Hegde Dennis S Meredith Christopher K Kepler Russel C Huang | 2012 | World Journal of Orthopedics2012，3，11： | 17 |
| 2 | In vivo radiometric analysis of glucose uptake and distribution in mouse bone显示文摘Bone formation and remodeling occurs throughout life and requires the sustained activity of osteoblasts and osteoclasts,particularly during periods of rapid bone growth.Despite increasing evidence linking bone cell activity to global energy homeostasis,little is known about the relative energy requirements or substrate utilization of bone cells.In these studies,we measured the uptake and distribution of glucose in the skeleton in vivo using positron-emitting^(18)F-fluorodeoxyglucose([^(18)F]-FDG) and non-invasive,high-resolution positron emission tomography/computed tomography(PET/CT) imaging and ex vivo autoradiography.Assessment of [^(18)F]-FDG uptake demonstrated that relative to other tissues bone accumulated a significant fraction of the total dose of the glucose analog.Skeletal accumulation was greatest in young mice undergoing the rapid bone formation that characterizes early development.PET/CT imaging revealed that [^(18)F]-FDG uptake was greatest in the epiphyseal and metaphyseal regions of long bones,which accords with the increased osteoblast numbers and activity at this skeletal site.Insulin administration significantly increased skeletal accumulation of [^(18)F]-FDG,while uptake was reduced in mice lacking the insulin receptor specifically in osteoblasts or fed a high-fat diet.Our results indicated that the skeleton is a site of significant glucose uptake and that its consumption by bone cells is subject to regulation by insulin and disturbances in whole-body metabolism. | Meredith L Zoch Diane S Abou Thomas L Clemens Daniel LJ Thorek Ryan C Riddle | 2016 | Bone Research2016，4，1： | 9 |
| 3 | Fluorescence resonance energy transfer studies on the interaction between the lactate transporter MCT1 and CD147 provide information on the topology and stoichiometry of the complex in situ显示文摘 | Wilson M C Meredith D Halestrap A P | 2002 | J Biol Chem2002，277，5： | 1 |
| 4 | Shock tube pyrolysis of pyridine显示文摘 | John C Mackie Meredith B ColketⅢ Peter F Nelson | 1990 | J Phys Chem1990，94，10： | 1 |
| 5 | Shock tube pyrolysis of pyrrole and kinetics modelling显示文摘 | John C Mackie Meredith B ColketⅢ Peter F Nelson | 1991 | Int J Chem Kinet1991，23，8： | 1 |
| 6 | Modified amino acids and peptides as substrates for the intestinal peptide transporter Pep T1显示文摘 | Meredith D Temple C S Guha N | 2000 | Eur J Biochem2000，267，12： | 1 |
| 7 | Agrobacterium-mediated transformation of Lilium 显示文摘 | COHEN A MEREDITH C P SANIEWSKI M | 1992 | Acta Hort1992，325，： | 1 |
| 8 | Eukaryotic initiation factor 4D, the hypusine-containing protein, is conserved among eukaryotes 显示文摘 | Gordon E D Mora R Meredith S C | 1987 | J Biol Chem1987，262，16： | 1 |
| 9 | Aortic stiffness affects the coronary blood flow response to percutaneous coronary intervention显示文摘 | LEUNG M C MEREDITH I T CAMERON J D | 2006 | Am J Physiol Heart Circ Hysiol2006，290，： | 1 |
| 10 | Structure and function of eukary- otic peptide transporters显示文摘 | Meredith D Boyd C A R | 2000 | Life Sci2000，57，： | 1 |
| 11 | Aortic stiffness affects the coronary blood flow response to percutaneous coronary intervention显示文摘 | LEUNG M C MEREDITH I T CAMERON J D | 2006 | Am J Physiol Heart Circ Physiol2006，290，： | 1 |
| 12 | The parentage of classic wine grape, Cabernet sauvignon 显示文摘 | Bowers J E Meredith C P | 1997 | Nature Genetics1997，16，1： | 1 |
| 13 | Hepatic Resection but Not Radio frequency Ablation Results in Tumor Growth and Increased Growth Factor Expression 显示文摘 | Meredith K Haemmerich D Qi C | 2007 | An- nals of Surgery2007，245，5： | 1 |
| 14 | The Effect of Water Pressure on Hydrocarbon Generation Reactions : Some Inferences from Laboratory Experiments显示文摘 | Carr A D Shape C E Meredith W | 2009 | Petroleum Geoscience2009，，15： | 1 |
| 15 | The effect of scaffold degradation rate on three-dimensional cell growth and angiogenesis显示文摘 | Sung HJ Meredith C Johnson C | 2004 | Biomaterials2004，25，26： | 1 |
| 16 | Leucine metabolism during fasting and exercise显示文摘 | Knapik J Meredith C Jones B | 1991 | J Appl Physiol1991，70，1： | 1 |
| 17 | Design and character- ization of a membrane permeable N-methyl amino acid- containing peptide that inhibits Af31-40 fibriUogenesis 显示文摘 | Gordon D J Tappe R Meredith S C | 2002 | J Pept Res2002，60，1： | 1 |
| 18 | In-home particle concentrations and childhood asthma morbidity 显示文摘 | MEREDITH C MCCORMACK PATRICK N | 2009 | Environ Health Perspect2009，117，2： | 1 |
| 19 | The influence of explant origin on tissue browning and shoot production in shoot tio culture of grapevine 显示文摘 | Yu D H Meredith C P J | 1994 | Horticuhure Science1994，69，5： | 1 |
| 20 | Cellular difference in Agrobac- terium susceptibility and regenerative capacity restrict the development of transgenic grapevines显示文摘 | COLBY S JUNCOSA A MEREDITH C P | 1991 | J Am See Hort Sei1991，116，： | 1 |
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