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| 1 | Lymph node ratio and preoperative CA 19-9 levels predict overall survival and recurrence-free survival in patients with resected pancreatic adenocarcinoma显示文摘AIM:Clinicopathologic factors predicting overall survival (OS) would help identify a subset to benefit from adjuvant therapy. METHODS: One hundred and sixty-nine patients patients from 1984 to 2009 with curative resections for pancreatic adenocarcinoma were included. Tumors were staged by American Joint Committee on Cancer 7th edition criteria. Univariate and multivariable analyses were performed using Kaplan-Meier methodology or Cox proportional hazard models. Log-rank tests were performed. Statistical inferences were assessed by two-sided 5% significance level. RESULTS: Median age was 67.1 (57.2-73.0) years with equal gender distribution. Tumors were in the head (89.3%) or body/tail (10.7%). On univariate analysis, adjuvant therapy, lymph node (LN) ratio, histologic grade, negative margin status, absence of peripancreatic extension, and T stage were associated with improved OS. Adjuvant therapy, LN ratio, histologic grade, number of nodes examined, negative LN status, and absence of peripancreatic extension were associated with improved recurrence-free survival (RFS). On multivariable analysis, LN ratio and carbohydrate antigen (CA) 19-9 levels were associated with OS. LN ratio was associated with RFS. CONCLUSION: The LN ratio and CA 19-9 levels are independent prognostic factors following curative resections of pancreatic cancer. | Sabrina C Wentz Zhi-Guo Zhao Yu Shyr Chan-Juan Shi Kay Washington Nipun B Merchant Fen Xia A Bapsi Chakravarthy | 2012 | World Journal of Gastrointestinal Oncology2012，4，10： | 3 |
| 2 | Immunohistochemical analysis of the Wnt/β-catenin signaling pathway in pancreatic neuroendocrine neoplasms显示文摘AIM: To investigate the role of the Wnt/β-catenin pathway in pancreatic neuroendocrine neoplasms(PanN ENs). METHODS: Tissue microarrays containing 88 PanN ENs were immunohistochemically labeled with antibodies to β-catenin, E-cadherin, adenomatous polyposis coli(APC), chromogranin and synaptophysin. One case had only metastatic tumors resected, whereas others(n = 87) received pancreatectomy with or without partial hepatectomy. Pathology slides, demographic, clinicopathologic, and follow up data were reviewed. Patients' demographics, clinicopathologic features, and immunohistochemical results from 87 primary tumors were compared between patients with low stage(stage Ⅰ/Ⅱ) and high stage(stage Ⅲ/Ⅳ) tumors. In addition, correlation of immunohistochemical results from primary tumors with disease-specific survival(DSS) was evaluated. RESULTS: Strong membranous β-catenin staining in the primary tumor was observed in all 13 stage Ⅲ/Ⅳ Pan NENs as compared to 47%(35/74) of stage Ⅰ/Ⅱtumors(P < 0.01). However, the strong membranous β-catenin staining was unassociated with tumor grade or DSS. Decreased membranous β-catenin staining was associated with decreased membranous E-cadherin labeling. Nuclear β-catenin staining was seen in 15%(2/13) of stage Ⅲ/Ⅳ Pan NENs as compared to 0%(0/74) of stage Ⅰ/Ⅱ tumors(P = 0.02). The case with metastasectomy only also showed nuclear β-catenin staining. Two of the three cases with nuclear β-catenin staining were familial adenomatous polyposis(FAP) patients. Lack of APC expression was seen in 70%(57/81) of the cases, including the 3 cases with nuclear β-catenin staining. Expression of E-cadherin and APC in primary tumor was not correlated with tumor grade, tumor stage, or disease specific survival. CONCLUSION: The Wnt/β-catenin pathway was altered in some PanN ENs, but did not Impact DSS. PanN ENs in FAP patients demonstrated nuclear β-catenin accumulation and loss of APC. | Vivian Weiss Julie Dueber Jesse P Wright Justin Cates Frank Revetta Alexander A Parikh Nipun B Merchant Chanjuan Shi | 2016 | World Journal of Gastrointestinal Oncology2016，8，8： | 3 |
| 3 | Proteomics and diabetic retinopathy显示文摘 | Merchant M L Klein J B | 2009 | Clin Lab Med2009，29，1： | 1 |
| 4 | The Effect of Microwave Radia tion on Coal Grindability 显示文摘 | Marland S Han B Merchant A | 2000 | Fuel2000，79，： | 1 |
| 5 | Ability of terminal QRS notching to dis- tinguish benign from malignant electrocardiographic forms of early repolarization显示文摘 | MERCHANT F M NOSEWORTHY P A WEINER R B | 2009 | Am J Cardiol2009，104，： | 1 |
| 6 | A rapid protein profiling system that speeds study of cancer and other diseases显示文摘 | Rubin R B Merchant M | 2000 | Am Clin Lab2000，19，8： | 1 |
| 7 | Extremity and trunk desmoid tumors: a multifaetorial analysis of outcome显示文摘 | MERCHANT N B LEWIS J J WOODRUFF J M | 1999 | Cancer1999，86，： | 1 |
| 8 | A prospective study of social support, anger expression and risk of periodontitis in men显示文摘 | Merchant AT Pitiphat W Ahmed B | 2003 | J Am Dent Assoc2003，134，12： | 1 |
| 9 | A human temporal bone study of changes in the basilar membrane of the apical turn in enoloymphatic hydrops显示文摘 | Nageris B Adams JC Merchant SN | 1996 | Am J Otol1996，17，： | 1 |
| 10 | Pathologyand pathophysiology of idiopathic sudden sensorineural hearing loss 显示文摘 | Merchant S N Adams J C Nadol J B Jr | 2005 | Otol Neurotol2005，26，2： | 1 |
| 11 | Assessment of US poultry worker respiratory risks 显示文摘 | DONHAM K J LEISTIKOW B MERCHANT J LEONARD S | 1990 | American Journal of Industrial Medicine1990，17，1： | 1 |
| 12 | Robust Neural - Network - Based Data Association and Multiple Model - Based Tracking of Multiple Point Targets 显示文摘 | M Zaveri S N Merchant Uday B Desai | 2007 | IEEE Transactions on Systems Man and Cybernetics Part C: Applications and Reviews2007，37，3： | 1 |
| 13 | Flocculants-an e co-friendly approach显示文摘 | B R Sharma N C Dhuldhoya U C Merchant | 2006 | Polym Environ2006，14，： | 1 |
| 14 | Pathology and pathophysiology of idiopathic sudden sensorineural hearing loss 显示文摘 | Merchant S N Adams J C Nadol J B Jr | 2005 | Otol Neurotol2005，26，2： | 1 |
| 15 | Mouse primordial germ cells use fibronection as a substrate for migration显示文摘 | Alvarez B A Merchant L H | 1986 | Exp Cell Res1986，165，2： | 1 |
| 16 | Characterizing the unfolded states of proteins using single-molecule FRET spectroscopy and molecular simulations显示文摘 | Merchant K A Best R B Louis J M Gopich I V Eaton W A | | 0，，： | 1 |
| 17 | Prone position breast irradia-tion显示文摘 | Merchant TE McCormick B | | 0，，01： | 1 |
| 18 | Prone position breast irradiation显示文摘 | Merchant T McCormick B | 1994 | Int J Radiat Oncol Biol Phys1994，30，1： | 1 |
| 19 | Proteomics and diabetic nephropathy 显示文摘 | Merchant M L Klein J B | 2007 | Semin Nephrol2007，27，6： | 1 |
| 20 | Pathophysiology of Meniere's syndrome: are symptoms caused by endolymphatic hydrops? 显示文摘 | MERCHANT S N ADAMS J C NADOL J B | 2005 | Otol Neurotol2005，26，1： | 1 |
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