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666篇 您的检索式：作者名="Mengel"

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	题名	作者	年代	出处	被引量
1	Inhibition of Cdk5 increases osteoblast differentiation and bone mass and improves fracture healing显示文摘Identification of regulators of osteoblastogenesis that can be pharmacologically targeted is a major goal in combating osteoporosis,a common disease of the elderly population. Here, unbiased kinome RNAi screening in primary murine osteoblasts identified cyclin-dependent kinase 5(Cdk5) as a suppressor of osteoblast differentiation in both murine and human preosteoblastic cells. Cdk5 knockdown by si RNA, genetic deletion using the Cre-lox P system, or inhibition with the small molecule roscovitine enhanced osteoblastogenesis in vitro. Roscovitine treatment significantly enhanced bone mass by increasing osteoblastogenesis and improved fracture healing in mice. Mechanistically, downregulation of Cdk5 expression increased Erk phosphorylation, resulting in enhanced osteoblast-specific gene expression. Notably, simultaneous Cdk5 and Erk depletion abrogated the osteoblastogenesis conferred by Cdk5 depletion alone, suggesting that Cdk5 regulates osteoblast differentiation through MAPK pathway modulation. We conclude that Cdk5 is a potential therapeutic target to treat osteoporosis and improve fracture healing.	Mubashir Ahmad Benjamin Thilo Krüger Torsten Kroll Sabine Vettorazzi Ann-Kristin Dorn Florian Mengele Sooyeon Lee Sayantan Nandi Dilay Yilmaz Miriam Stolz Naveen Kumar Tangudu David Carro Vázquez Johanna Pachmayr Ion Cristian Cirstea Maja Vujic Spasic Aspasia Ploubidou Anita Ignatius Jan Tuckermann	2022	Bone Research2022，10，3：	2
2	Prevalence of porcine parvovirus- induced reproductive failure: an abattoir study显示文摘	Mengeling W L	1978	J Am VetMedAssoc1978，172，11：	1
3	Prevalence of porcine parvovirus-induced reproductive failure:an abattoir study 显示文摘	Mengeling WL	1978	Journal of the American Veterinary Medical Association1978，172，：	1
4	Banff 2011 Meeting report:new concepts in antibody-mediated rejection显示文摘	Mengel M Sis B Haas M		0，，03：	1
5	Clinical effects of porcine reproductive and respiratory syndrome virus on pigs during the early postnatal interval显示文摘	Mengeling W L Lager K M Vorwald A C	1998	Am J Vet Res1998，59，1：	1
6	Safety and efficacy of vaccination of pregnant gilts against porcine reproductive and respiratory syndrome 显示文摘	Mengeling W L Lager K M Vorwald A C	1999	Vet Res1999，60，7：	1
7	Soil pH increase due to biological decarboxylation of organic anions显示文摘	YAN F SCHUBERTL S MENGEL K	1996	Soil Biology and Biochemistry1996，28，45：	1
8	Complete sequencing and mRNA expression analysis of the MEN- Ⅰ gene in adrenal myelolipoma 显示文摘	SCHULTE KM HEINZE M MENGEL M	2000	Horm Metab Res2000，32，3：	1
9	Prevalence of porcine parvovirus-induced reproductive; an abattioir study显示文摘	Mengeling W L	1978	Am Vet Med Assoc1978，172，：	1
10	Comparative safety and efficacy of attenuated single-strain and multi-strain vaccines for porcine reproductive and respiratory syndrome显示文摘	MENGELING W L LAGER K M VORWALD A C	2003	Vet Microbiol2003，93，1：	1
11	Identification and clinical assessment of suspected vaccine-related field strains of porcine reproductive and respiratory syndrome virus显示文摘	Mengeling W L Vorwald A C Lager K M	1999	Am J Vet Res1999，60，：	1
12	Implants in patients treated for generalized aggressive and chronic periodontitis:A 3-year prospective longitudinal study显示文摘	Mengel R Flores-de-Jacoby L	2005	J Periodontol2005，76，：	1
13	Crustal xenoliths from Tertiary volcanics of the Northern Hessian Depression显示文摘	K. Mengel	1990	Contributions to Mineralogy and Petrology1990，，1：	1
14	Antigen Mimicry be- tween Infectious Agents and Self or Environmental Antigens May Lead to Long- Term Regulation of Inflammation显示文摘	Pontes-de-Carvalho L Mengel J Figueiredo CA	2013	Front Immunol2013，4，：	1
15	Potassium in crop production显示文摘	Mengel K	1980	Adv Agron1980，33，：	1
16	Incidence of polyomavirus- nephropathy in renal allografts: influence of modem immuneosup- presive drugs显示文摘	Mengel M Marwedel M Radermacher J	2003	Nephrol Dial Transplant2003，18，：	1
17	Nitrate reductase activity in shoots and roots of maize seedlings as affected by the form of nitrogen nutrition and pH of the nutrition solution显示文摘	Mengel K Robin P Salsac L	1983	Plant Physiol1983，71，：	1
18	Evidence for divergence of restriction fragment length polymorphism patterns following invivo replication of porcine reproductive and respiratory syndrome virus显示文摘	Wesley R D Mengeling W L walter K M	1999	Am J Vet Res1999，60，：	1
19	Digital volume tomogra- phy in the diagnosis of periodontal defects : an in vitro study on native pig and human mandibles 显示文摘	Mengel R Candir M Shiratori K	2005	J Periodontol2005，76，：	1
20	Prognostic impact of Skp2and P27in human breast cancer显示文摘	Traub F Mengel M Lück HJ	2006	Breast Cancer Research andTreatment2006，99，2：	1

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