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您的检索式：作者名="Mengchen Ma"
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| 1 | Swertiamarin ameliorates diet-induced obesity by promoting adipose tissue browning and oxidative metabolism in preexisting obese mice显示文摘Obesity is a risk factor for many metabolic diseases.Efficient therapeutic strategies are urgently needed.Swertiamarin(STM)prevents obesity and the associated insulin resistance and inflammation.However,the therapeutic effects of STM on preexisting obesity remain unclear.Therefore,in this study we aim to investigate the effects of STM on energy expenditure and fat browning in mice with preexisting obesity.C57BL/6J mice are fed with a high-fat diet(HFD)for 8 weeks to induce obesity and then gavaged(or not)with STM for 10 weeks.The whole-body energy metabolism of mice is examined by indirect calorimetry.The results show that after 10 weeks of treatment,STM markedly prevents HFD-induced weight gain,chronic inflammation,insulin resistance,and hepatic steatosis.STM promotes oxygen consumption and energy expenditure.The level of uncoupling protein 1 is enhanced in the brown and white adipose tissues of STM-treated mice.STM increases the phosphorylation of AMP-activated protein kinase and the expressions of genes involved in fat oxidation,reducing fat deposition in skeletal muscles.Meanwhile,STM does not affect the intestinal microbiotic composition.Overall,STM supplementation may serve as a potential therapy for obesity. | Yuqin Zhu Haoran Li Mengchen Ma Dandan Li Ouyang Zhang Suili Cai Yajiao Wang Dandan Chen Shengnan Jin Chunming Ding Liang Xu | 2023 | Acta Biochimica et Biophysica Sinica2023，55，1： | 0 |
| 2 | Electrostatic and hydrophobic interaction cooperative nanochaperone regulates protein folding显示文摘Natural molecular chaperones utilize spatially ordered multiple molecular forces to effectively regulate protein folding.However,synthesis of such molecules is a big challenge.The concept of“aggregate science”provides insights to construct chemical entities(aggregates)beyond molecular levels to mimic both the structure and function of natural chaperone.Inspired by this concept,herein we fabricate a novel multi-interaction(i.e.,electrostatic and hydrophobic interaction)cooperative nanochaperone(multi-co-nChap)to regulating protein folding.This multi-co-nChap is fabricated by rationally introducing electrostatic interactions to the surface(corona)and confined hydrophobic microdomains(shell)of traditional single-hydrophobic interaction nanochaperone.We demonstrate that the corona electrostatic attraction facilitates the diffusion of clients into the hydrophobic microdomains,while the shell electrostatic interaction balances the capture and release of clients.By finely synergizing corona electrostatic attraction with shell electrostatic repulsion and hydrophobic interaction,the optimized multi-co-nChap effectively facilitated de novo folding of nascent polypeptides.Moreover,the synergy between corona electrostatic attraction,shell electrostatic attraction and shell hydrophobic interaction significantly enhanced the capability of multi-co-nChap to protect native proteins from denaturation at harsh temperatures.This work provides important insights for understanding and design of nanochaperone,which is a kind of ordered aggregate with chaperone-like activity that beyond the level of single molecule. | Xiaohui Wu Fei Deng Yujie Chen Mengchen Xu Feihe Ma Linqi Shi | 2024 | Aggregate2024，5，1： | 0 |
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