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| 1 | 急性缺血性与出血性卒中危险因素的对比研究显示文摘目的通过对1个大样本的医院脑卒中注册资料的分析,观察各种危险因素在脑卒中患者中的发生率,并对脑梗死与脑出血的危险因素,特别是心脏和动脉病变的因素进行比较。方法研究资料来自瑞士洛桑卒中注册的卒中患者共3901例,其中脑梗死3525例,脑出血376例,均预先对各项临床和辅助资料进行编码,输入计算机数据库。所有病例均进行系统的临床和辅助检查,心脏病变经心电图和超声心动图证实;颈内动脉和椎基底动脉的病变采用彩色超声多普勒、磁共振血管成像或常规脑血管造影确诊。结果高血压在脑出血和脑梗死患者中的发生率分别为53.7%和46.7%,两者相比差异有统计学意义(P<0.01)。高血压是本组脑卒中最突出的危险因素,其后依次是吸烟、轻度颈内动脉狭窄(≤50%)、高胆固醇血症、短暂性脑缺血发作、糖尿病以及心脏缺血。多因素分析研究发现,本组卒中患者无论是男性还是女性,吸烟、高胆固醇血症、短暂性脑缺血发作、心房纤颤、器质性心脏疾病以及动脉病变是脑梗死而非脑出血密切相关的危险因素。易患脑出血的惟一显著相关的危险因素是高血压(OR=0.64,P<0.01);心脏和动脉病变患者更容易发生脑梗死,但是,器质性心脏病和轻度颈内动脉狭窄在全体卒中患者中均特别常见。结论缺血性卒中和出血性卒中的危险因素并不一致,心脏和动脉病变是脑梗死而非脑出血的重要的危险因素,某些危险因素还存在性别差异。 | 刘新峰 徐格林 Guy van Melle Julien Bogousslavsky | 2005 | 中华神经科杂志2005，38，7： | 42 |
| 2 | Is there a real diagnostic impact of elastosonography and contrast-enhanced ultrasonography in the management of thyroid nodules?显示文摘Ultrasonography(US) and the new applications US elastography(USE) and contrast-enhanced US(CEUS) are used in the screening of thyroid nodules,for which fine-needle aspiration biopsy(FNAB) is the best single diagnostic test.The aim of the study was to compare the sensitivity,specificity,positive predictive value(PPV),and accuracy of the four examinations in nodules with cytological and histological diagnoses.The study used data from US,FNAB,USE(elasticity(ELX 2/1) index),and CEUS(Peak index and time to peak(TTP) index) evaluated in 73 thyroid nodules in 63 consecutive patients likely to undergo surgery.Cytological-histological correlation was available for 38 nodules.No correlation emerged between nodule size and cytological results.A significant(P=0.03) positive correlation between cumulative US findings and cytological results was found.In addition,significant correlations between cumulative US findings and cytology(P=0.02) and between cumulative US findings and histology(P<0.0001) were found.US showed the best specificity and PPV,and FNAB the best sensitivity.There was no significant difference in the ELX 2/1 index,Peak index,or TTP index among nodules subdivided according to cytological scores.No significant correlation was found between ELX 2/1 index,Peak index,and TTP index,on the one hand,and nodule size,US cumulative findings,cytology,and histology on the other hand.The sensitivity of the ELX 2/1 index was high,but its specificity was very low.The accuracy and PPV of USE were lower than those of the other procedures.Only the correlation between Peak index and cumulative US findings reached a value close to significance.Our ultimate aim is to minimise unnecessary thyroidectomy.US and FNAB continue to play a central diagnostic role.The use of a US score showed high specificity and PPV.The specificity of FNAB was low in this selected series because of the numbers of indeterminate cytological responses.USE and CEUS are innovative techniques that need to be standardized.The ELX 2/1 index,Peak index,and TTP index seem to be unrelated to histology.The best statistical data on USE and CEUS concerned their sensitivity and PPV,respectively.At present,USE and CEUS are too time-consuming and of limited utility in selecting patients for surgery. | Massimo GIUSTI Davide ORLANDI Giulia MELLE Barbara MASSA Enzo SILVESTRI Francesco MINUTO Gianni TURTULICI | 2013 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2013，14，3： | 17 |
| 3 | Adjuvant therapy in pancreatic cancer显示文摘Pancreatic cancer remains one of the leading causesof cancer related death worldwide with an overall fiveyear survival of less than 5%.Potentially curative surgery,which alone can improve 5-year survival to 10%,is an option for only 10%-20%of patients at presentation owing to local invasion of the tumour or metastaticdisease.Adjuvant chemotherapy has been shown toimprove 5-year survival to 20%-25%but conflicting evidence remains with regards to chemoradiation.In thisarticle we review the current evidence available frompublished randomised trials and discuss ongoing phaseⅢtrials in relation to adjuvant therapy in pancreaticcancer. | Owain Peris Jones James Daniel Melling Paula Ghaneh | 2014 | World Journal of Gastroenterology2014，20，40： | 5 |
| 4 | 心肌梗死后抑郁的预测:来自心肌梗死和抑郁干预试验(MIND-IT)的数据显示文摘Background: Depression following myocardial infarction(MI) is associated with complicated cardiac rehabilitation, noncompliance and poor prognosis. Whether de pression following MI can be predicted from variables routinely assessed during hospitalization for MI is unknown. Methods: Using data from the Myocardial INfar ction and Depression-Intervention Trial(MIND-IT),we identified 2177 MI patient s(mean age 63 years; 23%female). Patients were randomly divided into a derivati on and a validation sample. In the derivation sample, we analyzed variables pote ntially associated with the development of post-MI depressive disorder, which w ere tested in the validation sample. Results: In the year following MI, 18.5%su ffered from depressive disorder(ICD-10 criteria). In a multivariate model, fact ors associated with depression were younger age(OR 1.94; CI 1.38-2.74), hyperch olesterolemia(OR 1.68; CI 1.08-2.61), the use of calcium channel blockers at di scharge(OR 1.80; CI 1.20-2.71), and left ventricular ejection fraction(LVEF)(OR 4.14 for patients with LVEF< 30%; CI 2.42-7.10). The derived predictors were tested in the validation sample. The final model yielded two clinical predictors , i.e., younger age and severe LV-dysfunction, which correctly predicted post- discharge depression status in 82.9%of the MI patients. The model yielded a hig h negative predictive value(89%). A positive depression questionnaire(BDI) duri ng hospitalization increased the positive predictive value of 23%to 52%. Concl usions: During hospitalization for MI and using a two-step strategy with common clinical variables, i.e., younger age, severe LV-dysfunction and BDI score dur ing hospitalization, it is possible to identify MI patients with a high risk for subsequent development of depression. | Van Melle J.P. De Jonge P. Kuyper A.M.G. 孙凯 | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，2，9： | 3 |
| 5 | Myocardial Hsp70 phosphorylation and PKC-mediated cardioprotection following exercise显示文摘 | C. W. James Melling David B. Thorp Kevin J. Milne Earl G. Noble | 2009 | Cell Stress and Chaperones2009，，2： | 2 |
| 6 | Population Pharmacokinetic Modeling of Hydromorphone in Cardiac Surgery Patients during Postoperative Pain Therapy显示文摘 | Christian Jeleazcov Teijo I. Saari Harald Ihmsen Jan Mell Katharina Fr?hlich Ljubica Krajinovic J?rg Fechner Jürgen Schüttler | 2014 | Anesthesiology2014，，2： | 2 |
| 7 | Reducing the Risks of Cardiovascular Disease in Liver Allograft Recipients显示文摘 | George Mells James Neuberger | 2007 | Transplantation2007，，9： | 2 |
| 8 | Cerebral vascular autoregulation assessed by perfusion-CT in severe head trauma patients显示文摘 | Wintermark M Chiolero R Melle GV | 2006 | Neuroradiol2006，33，1： | 1 |
| 9 | Diabetes,glycemic control,and new-onset heart failure in patients with stable coronary artery disease:data from the heart and soul study显示文摘 | Joost P van Melle Mariska Bot | 2010 | Diabetes Care2010，33，9： | 1 |
| 10 | Prognostic significance of E-cadherin protein expression in pathologicalstage Ⅰ-Ⅲ endometrial cancer 显示文摘 | Mell LK Meyer JJ Tretiakova M | 2004 | Clin Cancer Res2004，10，16： | 1 |
| 11 | The Lansanne Stroke Registry:Analysis of 1000 Eouseeutive Patients with First Stroke 显示文摘 | Bogousslavsky J Van melle G Regli F | 1988 | Stroke(S0039-2499)1988，19，9： | 1 |
| 12 | GLP-1 analogs reduce hepatocyte steatosis and improve survival by enhancing the unfolded protein response and promoting macroautophagy显示文摘 | Sharma S Mells JE Fu PP | | 0，，： | 1 |
| 13 | Promoting urban greening:valuing the development of green infrastructure investments in the urban core of Manchester,UK显示文摘 | Mell I C Henneberry J Hehl-Lange S | 2013 | Urban Forest&Urban Greening2013，12，3： | 1 |
| 14 | The role of resistance and aerobic exercise training on insulin sensitivity measures in STZ-induced Type 1 diabetic rodents显示文摘 | Katharine E. Hall Matthew W. McDonald Kenneth N. Grisé Oscar A. Campos Earl G. Noble C.W. James Melling | 2013 | Metabolism2013，，： | 1 |
| 15 | Prognostic Significance of E-Cadherin Protein Expression in Pathological Stage I-III Endometrial Cancer显示文摘 | Loren K Mell Jeffrey J | 2004 | Clinical Cancer Research2004，10，： | 1 |
| 16 | Different predictors of neurological worsening in different causes of stroke显示文摘 | Yamamoto H Bogousslavsky J Van melle G | 1998 | Arch Neurol1998，55，4： | 1 |
| 17 | A denial-of-service resistant intrusion detection architecture 显示文摘 | Peter Mell Donald Marks Mark McLarnon | 2000 | Computer Security Division National Institute of Standards and Technology Elsevier Computer Networks 20002000，34，4： | 1 |
| 18 | A surgical technique for posterior lamellar keratoplasty 显示文摘 | MELLES G R EGGINK F A LANDER F | 1998 | Cornea1998，17，6： | 1 |
| 19 | A surgical technique for posterior lamellar keratoplasty显示文摘 | Melles GRJ Eggink FA Lander F | 1998 | Cornea1998，17，： | 1 |
| 20 | A surgical technique for posterior lamellar keratoplasty显示文摘 | Melles GR Egg ink FA Lander F | 1998 | Cornea1998，17，6： | 1 |
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