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| 1 | Upregulation of miR-489-3p and miR-630 inhibits oxaliplatin uptake in renal cell carcinoma by targeting OCT2显示文摘Renal cell carcinoma(RCC) is one of the most common malignant tumors affecting the urogenital system, accounting for 90% of renal malignancies. Traditional chemotherapy options are often the front-line choice of regimen in the treatment of patients with RCC, but responses may be modest or limited due to resistance of the tumor to anticarcinogen. Downregulated expression of organic cation transporter OCT2 is a possible mechanism underlying oxaliplatin resistance in RCC treatment. In this study, we observed that mi R-489-3 p and mi R-630 suppress OCT2 expression by directly binding to the OCT2 30-UTR. Meanwhile, via 786-O-OCT2-mi RNAs stable expression cell models, we found that mi RNAs could repress the classic substrate 1-methyl-4-phenylpyridinium(MPP+), fluorogenic substrate N,N-dimethyl-4-(2-pyridin-4-ylethenyl) aniline(ASP+), and oxaliplatin uptake by OCT2 both in vitro and in xenografts. In 33 clinical samples, mi R-489-3 p and mi R-630 were significantly upregulated in RCC, negatively correlating with the OCT2 expression level compared to that in adjacent normal tissues, using tissue microarray analysis and q PCR validation. The increased binding of c-Myc to the promoter of pri-mi R-630, responsible for the upregulation of mi R-630 in RCC, was further evidenced by chromatin immunoprecipitation and dual-luciferase reporter assay. Overall, this study indicated that mi R-489-3 p and mi R-630 function as oncotherapy-obstructing micro RNAs by directly targeting OCT2 in RCC. | Lu Chen Le Chen Zhiyuan Qin Jinxiu Lei Sheng Ye Kui Zeng Hua Wang Meidan Ying Jianqing Gao Su Zeng Lushan Yu | 2019 | Acta Pharmaceutica Sinica B2019，9，5： | 5 |
| 2 | Optimization and modeling of biohydrogen production by mixed bacterial cultures from raw cassava starch显示文摘从经由一个混合文化黑暗发酵过程的未加工的木薯淀粉的简历氢的生产被调查。H 2 的生产收益被调整底层集中和微生物混合比率优化。1.72 摩尔 H 2/mol 葡萄糖的最大的 H 2 收益与 10 g/L 的木薯淀粉集中被获得给 90% 利用率。底层利用并且氢和不稳定的丰满的酸的产生的动力学也被调查。底层利用列在后面假首先订反应动力学,而两 H 2 的生产和 VFA 与 Gompertz 方程相关。这些结果证明那棵木薯是 biohydrogen 的生产的一个好候选人。 | Shaojie Wang Zhihong Ma Ting Zhang Meidan Bao Haijia Su | 2017 | Frontiers of Chemical Science and Engineering2017，11，1： | 3 |
| 3 | Targeting slug-mediated non-canonical activation of c-Met to overcome chemo-resistance in metastatic ovarian cancer cells显示文摘Metastasis-associated drug resistance accounts for high mortality in ovarian cancer and remains to be a major barrier for effective treatment. In this study, SKOV3/T4, a metastatic subpopulation of ovarian cancer SKOV3 cells, was enriched to explore potential interventions against metastaticassociated drug resistance. Quantitative genomic and functional analyses were performed and found that slug was significantly increased in the SKOV3/T4 subpopulation and contributed to the high resistance of SKOV3/T4. Further studies showed that slug activated c-Met in a ligand-independent manner due to elevated levels of fibronectin and provoked integrin α V function, which was confirmed by the significant correlation of slug and p-Met levels in 121 ovarian cancer patient samples. Intriguingly,c-Met inhibitor(s) exhibited greatly enhanced anti-cancer effects in slug-positive ovarian cancer models both in vitro and in vivo. Additionally, IHC analyses revealed that slug levels were highly correlated with reduced survival of ovarian cancer patients. Taken together, this study not only uncovers the critical roles of slug in drug resistance in ovarian cancer but also highlights a promising therapeutic strategy by targeting the noncanonical activation of c-Met in slug-positive ovarian cancer patients with poor prognosis. | Linlin Chang Yan Hu Yingying Fu Tianyi Zhou Jun You Jiamin Du Lin Zheng Ji Cao Meidan Ying Xiaoyang Dai Dan Su Qiaojun He Hong Zhu Bo Yang | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 3 |
| 4 | Treatments for androgenetic alopecia and al- opecia areata: current options and future prospects 显示文摘 | Meidan VM Touitou E | 2001 | Drugs2001，61，1： | 1 |
| 5 | Cycle-time key factor identification and prediction in semiconductor manufacturing using machine learning and data mining显示文摘 | Meidan Y Lerner B Rabinowitz G | 2012 | IEEE Transactions on Semiconductor Manufacturing2012，24，2： | 1 |
| 6 | DJ-1 as a human oncogene and potential therapeutic target显示文摘 | Ji Cao Siyue Lou Meidan Ying Bo Yang | 2014 | Biochemical Pharmacology2014，，： | 1 |
| 7 | IMT-2000 standards:Radio aspects显示文摘 | Carsello R D Meidan R Allpress S | 1997 | IEEE Personal Communications1997，4，4： | 1 |
| 8 | Validation of a Static Franz Diffusion Cell System for In Vitro Permeation Studies显示文摘 | Shiow-Fern Ng Jennifer J. Rouse Francis D. Sanderson Victor Meidan Gillian M. Eccleston | 2010 | AAPS PharmSciTech2010，，3： | 1 |
| 9 | Phonophore is it a reality?显示文摘 | Meidan V Walmsley A Iriwin W | 1995 | Inter J Pharm Sci1995，118，： | 1 |
| 10 | Orthodontic positioning of an impacted supernumerary tooth: Report of a case显示文摘 | Brezniak N Meidan Z Lieberman M | 1990 | Quintessence lnt1990，21，4： | 1 |
| 11 | Effect of heat stress on ton- ic and GnRH-induced gonadotrophin secretion in relation toconcentration of oestradiol in plasma of cyclic cows 显示文摘 | Gilad E Meidan R Berman A | 1993 | J Reprod Fertil1993，99，2： | 1 |
| 12 | The effects of soil water potential on seed germination of four winter annuals in the Negev Desert highlands, Israel显示文摘 | Meidan E | 1990 | Journal of Arid Environments1990，，19： | 1 |
| 13 | Unique expression and regulatory mechanisms of EG-VEGF/prokineticin-1 and its receptors in the corpus luteum显示文摘 | Tatiana Kisliouk Helena Podlovni Rina Meidan | 2005 | Annals of Anatomy2005，，5： | 1 |
| 14 | De- layed effect of heat stress on steroid production in medium-sized and preovutatory bovine follicles 显示文摘 | Roth Z Meidan R Shaham-Albalancy A | 2001 | Reproduction2001，121，： | 1 |
| 15 | The effects of soil water potential on seed germination of four winter annuals in the Negev Desert highlands, Israel 显示文摘 | Meidan E | 1990 | Journal of Arid Environments1990，19，： | 1 |
| 16 | Phonophoresis---is it reality显示文摘 | | 1995 | Int J Pharm1995，118，： | 1 |
| 17 | Topological classification of adiabatic processes 显示文摘 | Meidan D Micklitz T Brouwer P W | 2011 | Physical Review B2011，84，19： | 1 |
| 18 | Spread spectrum access methods for wireless communications显示文摘 | Meidan R Milstein L B | 1995 | IEEE Communicationa Magazine1995，1，33： | 1 |
| 19 | Emerging technologies in transdermal therapeutics显示文摘 | Meidan VM Miehniak BB | 2004 | Am JTher2004，11，： | 1 |
| 20 | Spread spectrum access methods for wireless communications 显示文摘 | Kohno R Meidan R Milstein L B | 1995 | IEEE Trans Commum Mag1995，33，1： | 1 |
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