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| 1 | Effects of alkaline-electrolyzed and hydrogen-rich water,in a high-fat-diet nonalcoholic fatty liver disease mouse model显示文摘AIM To identify the effect of hydrogen-rich water(HRW) and electrolyzed-alkaline water(EAW) on high-fat-induced non-alcoholic fatty acid disease in mice.METHODS Mice were divided into four groups:(1) Regular diet(RD)/regular water(RW);(2) high-fat diet(HFD)/RW;(3) RD/EAW; and(4) HFD/EAW. Weight and body composition were measured. After twelve weeks, animals were sacrificed, and livers were processed for histology and reverse-transcriptase polymerase chain reaction. A similar experiment was performed using HRW to determine the influence and importance of molecular hydrogen(H2) in EAW. Finally, we compared the response of hepatocytes isolated from mice drinking HRW or RW to palmitate overload.RESULTS EAW had several properties important to the study:(1) pH = 11;(2) oxidation-reduction potential of-495 mV; and(3) H2 = 0.2 mg/L. However, in contrast to other studies, there were no differences between the groups drinking EAW or RW in either the RD or HFD groups. We hypothesized that the null result was due to low H2 concentrations. Therefore, we evaluated the effects of RW and low and high HRW concentrations(L-HRW = 0.3 mg H2/L and H-HRW = 0.8 mg H2/L, respectively) in mice fed an HFD. Compared to RW and L-HRW, H-HRW resulted in a lower increase in fat mass(46% vs 61%), an increase in lean body mass(42% vs 28%), and a decrease in hepatic lipid accumulation(P < 0.01). Lastly, exposure of hepatocytes isolated from mice drinking H-HRW to palmitate overload demonstrated a protective effect from H2 by reducing hepatocyte lipid accumulation in comparison to mice drinking regular water.CONCLUSION H2 is the therapeutic agent in electrolyzed-alkaline water and attenuates HFD-induced nonalcoholic fatty liver disease in mice. | Karen Jackson Noa Dressler Rotem S Ben-Shushan Ari Meerson Tyler W LeBaron Snait Tamir | 2018 | World Journal of Gastroenterology2018，24，45： | 9 |
| 2 | The role of lipid peroxidation in pathogenesis of ischemic damage and the antioxidant protection of the heart显示文摘 | Prof. F. Z. Meerson Dr. V. E. Kagan Yu. P. Kozlov L. M. Belkina Yu. V. Arkhipenko | 1982 | Basic Research in Cardiology1982，，5： | 2 |
| 3 | MicroRNA-132 Potentiates Cholinergic Anti-Inflammatory Signaling by Targeting Acetylcholinesterase显示文摘 | Iftach Shaked Ari Meerson Yochai Wolf Ran Avni David Greenberg Adi Gilboa-Geffen Hermona Soreq | 2009 | Immunity2009，，6： | 2 |
| 4 | Prevention of ischemic and reperfusion arrhythmias using the calmodulin blocker trifluoperazine显示文摘 | Meerson FZ Malyshev IIu Larionov NP | 1988 | Kardiologia1988，28，5： | 1 |
| 5 | Changes in brain MicroRNAs contribute to cholinergic stress reactions显示文摘 | Meerson A Cacheaux L Goosens KA | 2009 | J Mol Neurosci2009，40，12： | 1 |
| 6 | Close- packed floating clusters: granular hydrodynamics be- yond the freezing point? 显示文摘 | MEERSON B POSCHEL T BROMBERG Y | 2003 | Physical Review Letters2003，91，02： | 1 |
| 7 | MieroRNA-132 potentiates cholinergic anti-inflammatory signaling by targeting acetylcholinester- ase 显示文摘 | Shaked I Meerson A Wolf Y | 2009 | Immunity2009，31，6： | 1 |
| 8 | Prevention of ischemic and reperfusion arrhythmias using the calmodulin blocker trifluoperazine显示文摘 | Meerson FZ Malyshev IIu Larionov NP | 1988 | Kardiologiia1988，28，5： | 1 |
| 9 | MicroRNA-132 potentiates eholinergic anti-inflammatory signaling by targeting acetyleholines- terase 显示文摘 | Shaked I Meerson A Wolf Y | 2009 | Immunity2009，31，6： | 1 |
| 10 | On the mechanism of compensatory hyperfunetion and insufficiency of the heart显示文摘 | Meerson FZ | 1961 | Cor Vasa1961，3，： | 1 |
| 11 | MicroRNA-132 potentiates cholinergic anti-inflammatory signaling by targeting acetylcholinesterase显示文摘 | Shaked I Meerson A Wolf Y | 2009 | Immunity2009，31，6： | 1 |
| 12 | Stress induced arrhythmic disease of the heart-Part I 显示文摘 | Meerson FZ | 1994 | Clin Cardiol1994，17，： | 1 |
| 13 | Stress decrease in re-sistance of an organism to a tumor growth and its prevention bycentral inhibiting metabolites显示文摘 | Sukhikh GT Meerson FZ Mikhaleva II | 1984 | Dokl Akad Nauk USSR1984，278，3： | 1 |
| 14 | MicroRNA-132 potentiates cholinergic anti-inflammatory signaling by targeting acetylcholinesterase显示文摘 | Shaked I Meerson A Wolf Y | 2009 | Immunity2009，31，6： | 1 |
| 15 | Anotioxidative effects of interval hypoxic training显示文摘 | Meerson NV Tkatchouk EN | 1997 | Hyp Med J1997，，3： | 1 |
| 16 | Adaptation to high altitude hypoxia as a factor preventing development of myocardial ischemic necrosis显示文摘 | Meerson FZ Gomzakov OA Shimkovich MV | 1973 | Am J Cardiol1973，31，1： | 1 |
| 17 | Changes in brain MicroRNAs contribute to cholinergic stress reactions显示文摘 | Meerson A Cacheaux L Goosens KA | | 0，，1： | 1 |
| 18 | MicroRNA-132 potentiates cholinergic anti-inflammatory signaling by targeting acetylcholinesterase显示文摘 | Shaked I Meerson A Wolf Y | 2009 | Immunity2009，31，6： | 1 |
| 19 | MicroRNA-132 potentiates cholinergic anti-inflammatory signaling by targeting acctylcholine- sterase显示文摘 | Shaked 1 Meerson A Wolf Y | 2009 | Inmaunity2009，31，6： | 1 |
| 20 | The effect of adaptation to a physical load on the endotheliummediated reactions of isolated vessels and NO production in rats 显示文摘 | MANUKHINA E B LAPSHIN A V MEERSON F Z | 1996 | Fiziol Zh Im I M Sechenova1996，82，7： | 1 |
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