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| 1 | Potential predictive factors for pathologic complete response after the neoadjuvant treatment of rectal adenocarcinoma:a single center experience显示文摘Objective:To assess the response rate of patients with rectal adenocarcinoma to neoadjuvant therapy and to identify the predictors of histological regression after neoadjuvant radiotherapy(RT)or concurrent chemoradiotherapy(CCRT).Methods:This study recruited 64 patients.The patients had resectable cancer of the lower and the middle rectum(T3/T4 and/or N+)without distant metastasis and received neoadjuvant RT or CCRT followed by radical surgery with total mesorectal excision(TME)between January 2006 and December 2011.The patients were classified into non-response(NR),partial response(PR),and pathologic complete response(p CR)based on the Dworak tumor regression grading system.Results:The median age of patients was 57 years(ranging from 22 to 85).A total of 24 patients were treated with neoadjuvant CCRT,whereas 40 patients were treated with RT alone.Abdominoperineal resection(APR)was performed on 29 patients(45%).Anterior resection with TME was performed on 34 patients(53%).One patient had local resection.Histologically,12(19%),24(73%),and 28(44%)patients exhibited p CR,PR,and NR,respectively.Univariate analysis revealed that the predictors of tumor regression were as follows:the absence of lymph node involvement from initial imaging(c N0)(P=0.021);normal initial carcinoembryonic antigen(CEA)level(P=0.01);hemoglobin level≥12 g/dl(P=0.009);CCRT(P=0.021);and tumor downstaging in imaging(P=0.001).Multivariate analysis showed that the main predictors of p CR were CT combined with neoadjuvant RT,c N0stage,and tumor regression on imaging.Conclusions:Identifying the predictors of p CR following neoadjuvant therapy aids the selection of responsive patients for nonaggressive surgical treatment and possible surveillance. | Feryel Letaief Meher Nasri Mouna Ayadi Khedija Meddeb Amina Mokrani Yosra Yahyaoui Nesrine Chraiet Henda Raies Amel Mezlini | 2017 | Cancer Biology & Medicine2017，14，3： | 3 |
| 2 | Distinct chromosomal abnormality pattern in primary liver cancer of non-B, non-C patients 显示文摘 | Marchio A Pineau P Meddeb M | 2000 | Oncogene2000，19，33： | 1 |
| 3 | Internet QoS:pieces of the puzzle 显示文摘 | Aref Meddeb | 2010 | IEEE Com Magazine2010，48，1： | 1 |
| 4 | Vector-valued coherent risk measures显示文摘 | Jouini E Meddeb M Touzi N | 2004 | Finance and Stochastics2004，8，4： | 1 |
| 5 | Recurrent chromosomal abnormalities in hepatocellular carcinoma detected by comparative genomic hybridization显示文摘 | Marchio A Meddeb M Pineau P | 1997 | Genes Chromosomes Cancer1997，18，1： | 1 |
| 6 | ,Cerebral vasculitis in a pa- tient with rheumatoid arthritis显示文摘 | Mrabet D Meddeb N Ajlani HH | 2007 | Joint Bone Spine2007，74，2： | 1 |
| 7 | Risk of ischemic stroke in pa- tients with polymyositis and dermatomyositis:a systematic review and meta-analysis显示文摘 | Mrabet D Meddeb N Ajlani H | 2015 | Rheumatol Int2015，35，5： | 1 |
| 8 | Internet QoS:pieces of the puzzle显示文摘 | Meddeb Aref | 2010 | IEEE Communications Magazine2010，，1： | 1 |
| 9 | Recurrent chromosomal abnormalities in hepatocellular carcinoma detected by comparative genomic hybridization显示文摘 | Marchio A Meddeb M Pineau P | 1997 | Genes Chromosomes Cancer1997，18，1： | 1 |
| 10 | Chromosomal abnormalities in liver cell dysplasia detected by comparative genomic hybfidisation 显示文摘 | Marchio A Terris B Meddeb M | 2001 | Mol Pathol2001，54，4： | 1 |
| 11 | Front buried metallic contacts and thin porous silicon combination for efficient polycrystalline silicon solar cells显示文摘 | M. Ben Rabha M.F. Boujmil N. Meddeb M. Saadoun B. Bessa?s | 2005 | Thin Solid Films2005，，： | 1 |
| 12 | Transfusion-related acute lung injury (TRALI) during remission induction course of acute myeloid leukemia: A possible role for all-transretinoic-acid (ATRA)?显示文摘 | R. Jeddi R. Mansouri K. Kacem E. Gouider H.B. Abid Z. Belhadjali B. Meddeb | 2008 | Pathologie Biologie2008，，6： | 1 |
| 13 | Vitamin D deficiency in Tunisia显示文摘 | Meddeb N Sahli H Chahed M | 2005 | Osteoporos Int2005，16，2： | 1 |
| 14 | Identification of thermophilic bacterial strains producing thermotolerant hydrolytic enzymes from manure compost显示文摘 | Charbonneau D M Meddeb - Mouelhi F Boissinot M Sirois M | 2012 | Indian Journal of Microbiology2012，52，1： | 1 |
| 15 | Foreign Exchange Market Efficiency: Fractional Cointegration Approach 显示文摘 | Belkacem Lotfi El Zahael Meddeb and Heni Boubaker | 2005 | Working Paper2005，，： | 1 |
| 16 | Effect of pterygium surgery on corneal topography显示文摘 | Errais K Bouden J Mili-Boussen I Anane R Beltaif O Meddeb Ouettani A | | 0，，04： | 1 |
| 17 | Unstable interaction in multiple criteria decision problems显示文摘 | Abdelaziz F B Meddeb O | 2015 | Journal of Multi-criteria De- cision Analysis2015，22，： | 1 |
| 18 | Effect of pterygium surgery on corneal topography 显示文摘 | Errais K Bouden J Mili-Boussen I Anane R Beltaff O Meddeb Ouertani A | 2008 | Eur J Ophthalmol2008，18，2： | 1 |
| 19 | Effect of TT virus infection on hepatocellular carcinoma development:results of a Euro-Asian survey显示文摘 | Pineau P Meddeb M Raselli R | | 0，，3： | 1 |
| 20 | Front buried metallic contacts and thin porous silicon combination for efficient polycrystalline silicon solar cells 显示文摘 | RABHA M B BOUJMIL M F MEDDEB N | 2006 | Thin Solid Films2006，，： | 1 |
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