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| 1 | Effect of prolonged cryptorchidism on germ cell apoptosisand testicular sperm count显示文摘Aim:To evaluate the long term effect of experimental cryptorchidism on germ cell apoptotic rate and testicular sperm content in adult rats.Methods:Bilateral cryptorchidism was created in 40 adult male Sprague-Dawley rats by surgically manipulating the testes into the abdominal cavity and closing the internal inguinal ring.The rats were sacrificed and the testes removed 6 hours and 2,4,7,21,28 and 56 days after cryptorchidism.Germ cell apoptosis was quantified by means of TUNEL assay and apoptosis was confirmed using transmission electron microscopy.Results:The rate of apoptosis peaked at 4 days of cryptorchidism and then progressively declined to a nadir at 14 days of cryptorchidism.At 56 days of cryptorchidism,the germinal epithelium was largely depleted by the apoptotic process and only a few mature sperm were seen within the testis.At this point,a few tubules were seen to be repopulating with primary spermatocytes and the level of germ cell apoptosis began to increase marginally.Testicular sperm count (TSC) began to decline rapidly at day 7 of cryptorchidism.Only a few mature sperm were found in the testes of rats following 56 days of cryptorchidism.Multinucleated giant cells (MGC) were most numerous within the seminiferous tubules at day 4.At day 7,35% of MGCs were TUNEL positive.At all subsequent time points,however,MGCs fail to stain positive for apoptosis.This resumption of increased apoptosis coincided with the appearance of a population of primary spermatocytes in some seminiferous tubules.Moreover,there was not a corresponding increase in the number of mature sperm after 56 days of cryptorchidism.Conclusion:The decline in germ cell apoptosis after 4 days of cryptorchidism can be attributed to be the result of an overall depletion of germ cells.It appears that after a prolonged cryptorchidism (56 days),there is a limited resumption of spermatogenesis presumably as a result of a decrease in the maturing germ cells undergoing programmed cell death.(Asian JAndrol2004 Mar;6:47-51) | Albaha Barqawi Herald Trummer Randall Meacham | 2004 | Asian Journal of Andrology2004，6，1： | 7 |
| 2 | High toughness high hardness iron based PTAW weld materials 显示文摘 | Branagan D J Marshall M C Meacham B E | 2006 | Materials Science and Engineering: A2006，428，1： | 1 |
| 3 | High toughness high hardness iron based PTAW weld materials显示文摘 | Branagan D J Marshall M C Meacham B E | 2006 | Materials Science and Engineering A2006，428，1： | 1 |
| 4 | Evaluation and treatment of ejaculatory duct obstruction in the infertile male显示文摘 | MEACHAM RB HELLERSTEIN DK LIPSHULTZ LI | 1993 | Fertil Steril1993，59，2： | 1 |
| 5 | Hepatic maturation in differentiating embryonic stem cells in vitro显示文摘 | Takashi Hamazaki Yasuhiko Iiboshi Masahiro Oka Philip J. Papst Amy M. Meacham Leonard I. Zon Naohiro Terada | 2001 | FEBS Letters2001，，1： | 1 |
| 6 | Kidney injury molecule-I is up-regulated in renal epithelial cells in response to oxalate in vitro and in renal tissues in response to hyperoxaluria /n v/vo 显示文摘 | Khandrika L Koul S Meacham RB | 2012 | PLoS One2012，7，44： | 1 |
| 7 | Renal artery aneurysm:selective treatment for hypertension and prevention of rupture显示文摘 | MARTIN R S MEACHAM P W DITESHEIM J A | 1989 | J Vasc Surg1989，9，1： | 1 |
| 8 | The role of silicone ureteral stents in extracorporeal shock wave lithotripsy of large renal calculi 显示文摘 | Meacham RB Griffith DP | 1988 | J Urol1988，139，： | 1 |
| 9 | The functional effects of acid ceramidase overexpression in prostate cancer progression and resistance to chemotherapy显示文摘 | Sand AF Meacham WD Bai A | 2007 | Cancer Biol Ther2007，6，9： | 1 |
| 10 | High toughness high hardness iron based PTAW weld materials 显示文摘 | Branagan D J Marshall M C Meacham B E | 2006 | Materials Science and Engineering Part A2006，428，12： | 1 |
| 11 | Aluminum, boron, calcium,copper, iron, magnesium, manganese, molybdenum, phosphorus, potassium, sodium and zinc: Concentrations in common western 显示文摘 | Curtiss Hunt Susan L Meacham | 2001 | Foods and Estimated Daily2001，101，9： | 1 |
| 12 | High- performance nanoseale composite coatings for boiler applications 显示文摘 | Branagan D J Breitsameter M Meacham B E | 2005 | Journal of Thermal Spray Technology2005，14，2： | 1 |
| 13 | The History of the American Dream 显示文摘 | Jon Meacham | 2012 | Time2012，，6： | 1 |
| 14 | Experimental varicocele induce testicular germ cell apoptosis in the rat显示文摘 | BARQAWI A CARUSO A MEACHAM RB | | 0，，： | 1 |
| 15 | Performance-based fire safety engineering: an introduction of basic concepts 显示文摘 | Meacham B J | 1995 | Journal of Fire Protection Engineering1995，7，2： | 1 |
| 16 | Antiestrogenic effects of the novel sphingosine kinase-2 inhibitor ABC294640 显示文摘 | Antoon J W White M D Meacham W D Slaughter E M Muir S E Elliott S | 2010 | Endocrinology2010，151，： | 1 |
| 17 | In vivo RNAiscreening identifies regulators of actin dynamics as key determinants of lymphoma progression显示文摘 | MEACHAM C E HO E E DUBROVSKY E | 2009 | Nat Genet2009，41，10： | 1 |
| 18 | High-performance nanoscale composite coatings for boiler applications显示文摘 | Branagan D J Breitsameter M Meacham B E | 2005 | Journal of Thermal Spray Technology2005，14，2： | 1 |
| 19 | Evaluation and treatment of ejaculatory duct obstruc- tion in the infertile male 显示文摘 | Meacham R B Hellerstein D K Lipshuhz L I | 1993 | Fertil Steril1993，59，2： | 1 |
| 20 | High energy electron beam irradiation: an advanced oxidation process for the treatment of aqueous based organic hazardous wastes 显示文摘 | Cooper W J Nicklsen M G Meacham D E Tomas D W | 1992 | Water Quality Research Journal of Carada1992，27，： | 1 |
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