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| 1 | Effect of prolonged cryptorchidism on germ cell apoptosisand testicular sperm count显示文摘Aim:To evaluate the long term effect of experimental cryptorchidism on germ cell apoptotic rate and testicular sperm content in adult rats.Methods:Bilateral cryptorchidism was created in 40 adult male Sprague-Dawley rats by surgically manipulating the testes into the abdominal cavity and closing the internal inguinal ring.The rats were sacrificed and the testes removed 6 hours and 2,4,7,21,28 and 56 days after cryptorchidism.Germ cell apoptosis was quantified by means of TUNEL assay and apoptosis was confirmed using transmission electron microscopy.Results:The rate of apoptosis peaked at 4 days of cryptorchidism and then progressively declined to a nadir at 14 days of cryptorchidism.At 56 days of cryptorchidism,the germinal epithelium was largely depleted by the apoptotic process and only a few mature sperm were seen within the testis.At this point,a few tubules were seen to be repopulating with primary spermatocytes and the level of germ cell apoptosis began to increase marginally.Testicular sperm count (TSC) began to decline rapidly at day 7 of cryptorchidism.Only a few mature sperm were found in the testes of rats following 56 days of cryptorchidism.Multinucleated giant cells (MGC) were most numerous within the seminiferous tubules at day 4.At day 7,35% of MGCs were TUNEL positive.At all subsequent time points,however,MGCs fail to stain positive for apoptosis.This resumption of increased apoptosis coincided with the appearance of a population of primary spermatocytes in some seminiferous tubules.Moreover,there was not a corresponding increase in the number of mature sperm after 56 days of cryptorchidism.Conclusion:The decline in germ cell apoptosis after 4 days of cryptorchidism can be attributed to be the result of an overall depletion of germ cells.It appears that after a prolonged cryptorchidism (56 days),there is a limited resumption of spermatogenesis presumably as a result of a decrease in the maturing germ cells undergoing programmed cell death.(Asian JAndrol2004 Mar;6:47-51) | Albaha Barqawi Herald Trummer Randall Meacham | 2004 | Asian Journal of Andrology2004，6，1： | 7 |
| 2 | Arandomized outcomes trial of ureteral stents for extracorporeal shock wave lithotripsy of solitary kidney or proximal ureteral stones显示文摘 | Chandhoke PS Barqawi AZ Wernecke C | 2002 | J Urol2002，167，： | 1 |
| 3 | Experimental varicocele induces testicular germ cell apoptosis in the rat显示文摘 | Barqawi A | 2004 | J Urol2004，171，： | 1 |
| 4 | The use of flutamide as a single antiandrogen treatment for hormone-refractory prostate cancer 显示文摘 | Barqawi A Akduman B Abouelfadel Z | 2003 | BJU Int2003，92，7： | 1 |
| 5 | Henoch-Schonlein purpura in children:influence of age on the incidence of nephritis and arthritis显示文摘 | Hamdan JM Barqawi MA | | 0，，04： | 1 |
| 6 | Henoch-Schonlein purpura in children:influence of age on the incidence of nephritis and arthritis显示文摘 | Hamdan JM Barqawi MA | 2008 | Saudi Med J2008，，： | 1 |
| 7 | A randomized outcomes trial of ureteral stents for extracorporeal shockwave lithotripsy of solitary kidney or proximal ureteral stones显示文摘 | Chandhoke PS Barqawi AZ Wernecke C | 2002 | J Urol2002，167，5： | 1 |
| 8 | Metronomic therapy with cyclophosphamide and dexamethasone for prostate carcinoma显示文摘 | Glode LM Barqawi A Crighton F | 2003 | Caneer2003，98，8： | 1 |
| 9 | The association of time of day and serum testosterone concentration in a large screening population显示文摘 | Crawford ED Barqawi AB | 2007 | BJU Internatonal2007，100，3： | 1 |
| 10 | Experimental varicocele induce testicular germ cell apoptosis in the rat显示文摘 | BARQAWI A CARUSO A MEACHAM RB | | 0，，： | 1 |
| 11 | Henoch-Schonlein purpura in children:influence of age on the incidence of nephritis and arthritis显示文摘 | Hamdan JM Barqawi MA | 2008 | Saudi Med J2008，29，4： | 1 |
| 12 | Prostate cancer chemoprevention: an overview of United States trials 显示文摘 | Barqawi A Thompson IM Crawford ED | 2004 | J Urol2004，171，22： | 1 |
| 13 | The role of 3-dimensional mapping biopsy in decision making for treatment of apparent early stage prostate cancer显示文摘 | Barqawi AB Rove KO Gholizadeh S | | 0，，01： | 1 |
| 14 | A randomized outcomes trial of ureteral stents for extracorporeal shock wave lithotripsy of solitary kidney or proximal ureteral stones显示文摘 | Chandhoke P S Barqawi A Z Chee-Awai R A | 2002 | J Urol2002，167，5： | 1 |
| 15 | Henoch-Sc honlein purpura in children:influence of age on the incidence of nephritis and arthritis显示文摘 | Hamdan JM Barqawi MA | 2008 | Saudi Med J2008，，： | 1 |
| 16 | A randomized outcomes trial of ureteral stens for extracorporeal shock wave lithotripsy shock of solitary kidney or proximal stones显示文摘 | Chandhoke PS Barqawi AZ Werneck C | 2002 | Urol2002，167，5： | 1 |
| 17 | The insults of illicit drug use on male fertility 显示文摘 | Fronczak CM Kim ED Barqawi AB | 2012 | J Androl2012，33，4： | 1 |
| 18 | Apoptosis:its importance in spermatogenic dysfunction显示文摘 | Kim ED Barqawi AZ Seo JT | 2002 | Urol Clin North Am2002，29，： | 1 |
| 19 | Role of laparoscopy in patients with previous negative exploration for impalpable testis显示文摘 | Barqawi AZ Blyth B Jordan GH | 2003 | Urology2003，61，6： | 1 |
| 20 | A randomized outcomes trial of ureteral stents for extra corporal shockwave lithotripsy of solitary kidney or proximal ureteral stones显示文摘 | CHANDHOKE PS BARQAWI AZ WERNECKE C | 2002 | J Urol2002，167，： | 1 |
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